Structural mechanism underlying primary and secondary coupling between GPCRs and the Gi/o family

G protein-coupled receptors (GPCRs) can couple to more than one G protein subtype, and the coupling efficiency varies depending on the GPCR-G protein pair. Here authors use hydrogen/deuterium exchange mass spectrometry and mutagenesis to study the structural mechanism underlying primary and secondar...

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Autores principales: Hee Ryung Kim, Jun Xu, Shoji Maeda, Nguyen Minh Duc, Donghoon Ahn, Yang Du, Ka Young Chung
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/07c8ff45757c4596b553213efaff5436
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