Antioxidant Activity, Molecular Docking, Quantum Studies and In Vivo Antinociceptive Activity of Sulfonamides Derived From Carvacrol

The synthesis and antioxidant, antinociceptive and antiedematogenic activities of sulfonamides derived from carvacrol—a druglike natural product—are reported. The compounds showed promising antioxidant activity, and sulfonamide derived from morpholine (S1) demonstrated excellent antinociceptive and...

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Autores principales:	Aldo S. de Oliveira, Luana C. Llanes, Ricardo J. Nunes, Catharina Nucci-Martins, Anacleto S. de Souza, David L. Palomino-Salcedo, María J. Dávila-Rodríguez, Leonardo L. G. Ferreira, Adair R. S. Santos, Adriano D. Andricopulo
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	sulfonamides pain carvacrol molecular modeling antioxidant Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/07ca78a81f984448bf1d9ef595d087f9
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spelling	oai:doaj.org-article:07ca78a81f984448bf1d9ef595d087f92021-11-30T12:53:15ZAntioxidant Activity, Molecular Docking, Quantum Studies and In Vivo Antinociceptive Activity of Sulfonamides Derived From Carvacrol1663-981210.3389/fphar.2021.788850https://doaj.org/article/07ca78a81f984448bf1d9ef595d087f92021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphar.2021.788850/fullhttps://doaj.org/toc/1663-9812The synthesis and antioxidant, antinociceptive and antiedematogenic activities of sulfonamides derived from carvacrol—a druglike natural product—are reported. The compounds showed promising antioxidant activity, and sulfonamide derived from morpholine (S1) demonstrated excellent antinociceptive and antiedematogenic activities, with no sedation or motor impairment. The mechanism that underlies the carvacrol and derived sulfonamides’ relieving effects on pain has not yet been fully elucidated, however, this study shows that the antinociceptive activity can be partially mediated by the antagonism of glutamatergic signaling. Compound S1 presented promising efficacy and was predicted to have an appropriate medicinal chemistry profile. Thus, derivative S1 is an interesting starting point for the design of new leads for the treatment of pain and associated inflammation and prooxidative conditions.Aldo S. de OliveiraAldo S. de OliveiraLuana C. LlanesRicardo J. NunesCatharina Nucci-MartinsCatharina Nucci-MartinsAnacleto S. de SouzaDavid L. Palomino-SalcedoMaría J. Dávila-RodríguezLeonardo L. G. FerreiraAdair R. S. SantosAdriano D. AndricopuloFrontiers Media S.A.articlesulfonamidespaincarvacrolmolecular modelingantioxidantTherapeutics. PharmacologyRM1-950ENFrontiers in Pharmacology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	sulfonamides pain carvacrol molecular modeling antioxidant Therapeutics. Pharmacology RM1-950
spellingShingle	sulfonamides pain carvacrol molecular modeling antioxidant Therapeutics. Pharmacology RM1-950 Aldo S. de Oliveira Aldo S. de Oliveira Luana C. Llanes Ricardo J. Nunes Catharina Nucci-Martins Catharina Nucci-Martins Anacleto S. de Souza David L. Palomino-Salcedo María J. Dávila-Rodríguez Leonardo L. G. Ferreira Adair R. S. Santos Adriano D. Andricopulo Antioxidant Activity, Molecular Docking, Quantum Studies and In Vivo Antinociceptive Activity of Sulfonamides Derived From Carvacrol
description	The synthesis and antioxidant, antinociceptive and antiedematogenic activities of sulfonamides derived from carvacrol—a druglike natural product—are reported. The compounds showed promising antioxidant activity, and sulfonamide derived from morpholine (S1) demonstrated excellent antinociceptive and antiedematogenic activities, with no sedation or motor impairment. The mechanism that underlies the carvacrol and derived sulfonamides’ relieving effects on pain has not yet been fully elucidated, however, this study shows that the antinociceptive activity can be partially mediated by the antagonism of glutamatergic signaling. Compound S1 presented promising efficacy and was predicted to have an appropriate medicinal chemistry profile. Thus, derivative S1 is an interesting starting point for the design of new leads for the treatment of pain and associated inflammation and prooxidative conditions.
format	article
author	Aldo S. de Oliveira Aldo S. de Oliveira Luana C. Llanes Ricardo J. Nunes Catharina Nucci-Martins Catharina Nucci-Martins Anacleto S. de Souza David L. Palomino-Salcedo María J. Dávila-Rodríguez Leonardo L. G. Ferreira Adair R. S. Santos Adriano D. Andricopulo
author_facet	Aldo S. de Oliveira Aldo S. de Oliveira Luana C. Llanes Ricardo J. Nunes Catharina Nucci-Martins Catharina Nucci-Martins Anacleto S. de Souza David L. Palomino-Salcedo María J. Dávila-Rodríguez Leonardo L. G. Ferreira Adair R. S. Santos Adriano D. Andricopulo
author_sort	Aldo S. de Oliveira
title	Antioxidant Activity, Molecular Docking, Quantum Studies and In Vivo Antinociceptive Activity of Sulfonamides Derived From Carvacrol
title_short	Antioxidant Activity, Molecular Docking, Quantum Studies and In Vivo Antinociceptive Activity of Sulfonamides Derived From Carvacrol
title_full	Antioxidant Activity, Molecular Docking, Quantum Studies and In Vivo Antinociceptive Activity of Sulfonamides Derived From Carvacrol
title_fullStr	Antioxidant Activity, Molecular Docking, Quantum Studies and In Vivo Antinociceptive Activity of Sulfonamides Derived From Carvacrol
title_full_unstemmed	Antioxidant Activity, Molecular Docking, Quantum Studies and In Vivo Antinociceptive Activity of Sulfonamides Derived From Carvacrol
title_sort	antioxidant activity, molecular docking, quantum studies and in vivo antinociceptive activity of sulfonamides derived from carvacrol
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/07ca78a81f984448bf1d9ef595d087f9
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Antioxidant Activity, Molecular Docking, Quantum Studies and In Vivo Antinociceptive Activity of Sulfonamides Derived From Carvacrol

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