Robust aptamer–polydopamine-functionalized M-PLGA–TPGS nanoparticles for targeted delivery of docetaxel and enhanced cervical cancer therapy

Robust aptamer–polydopamine-functionalized M-PLGA–TPGS nanoparticles for targeted delivery of docetaxel and enhanced cervical cancer therapy

Guojun Xu,1–3,* Xinghua Yu,2,* Jinxie Zhang,1,2,* Yingchao Sheng,4 Gan Liu,2 Wei Tao,1,2 Lin Mei1,2 1School of Life Sciences, Tsinghua University, Beijing, 2Graduate School at Shenzhen, Tsinghua University, Shenzhen, 3School of Materials Science and Engineering, Tsinghua University, Beiji...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Xu GJ, Yu XH, Zhang JX, Sheng YC, Liu G, Tao W, Mei L
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2016
Materias:
Dopamine
AS1411 Aptamer
Active targeting
Polymeric NPs
Enhanced cervical chemotherapy
Medicine (General)
R5-920
Acceso en línea:https://doaj.org/article/07d40d5fb7d5430eb66e577b51f4bfcc
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:07d40d5fb7d5430eb66e577b51f4bfcc
record_format dspace
spelling oai:doaj.org-article:07d40d5fb7d5430eb66e577b51f4bfcc2021-12-02T07:22:50ZRobust aptamer–polydopamine-functionalized M-PLGA–TPGS nanoparticles for targeted delivery of docetaxel and enhanced cervical cancer therapy1178-2013https://doaj.org/article/07d40d5fb7d5430eb66e577b51f4bfcc2016-06-01T00:00:00Zhttps://www.dovepress.com/robust-aptamerndashpolydopamine-functionalized-m-plgandashtpgs-nanopar-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Guojun Xu,1–3,* Xinghua Yu,2,* Jinxie Zhang,1,2,* Yingchao Sheng,4 Gan Liu,2 Wei Tao,1,2 Lin Mei1,2 1School of Life Sciences, Tsinghua University, Beijing, 2Graduate School at Shenzhen, Tsinghua University, Shenzhen, 3School of Materials Science and Engineering, Tsinghua University, Beijing, 4Department of Orthopedic Surgery, Changshu Hospital of TCM, Changshu, People’s Republic of China *These authors contributed equally to this work Abstract: One limitation of current biodegradable polymeric nanoparticles (NPs) is the contradiction between functional modification and maintaining formerly excellent bioproperties with simple procedures. Here, we reported a robust aptamer–polydopamine-functionalized mannitol-functionalized poly(lactide-co-glycolide) (M-PLGA)–D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) nanoformulation (Apt-pD-NPs) for the delivery of docetaxel (DTX) with enhanced cervical cancer therapy effects. The novel DTX-loaded Apt-pD-NPs possess satisfactory advantages: 1) increased drug loading content and encapsulation efficiency induced by star-shaped copolymer M-PLGA–TPGS; 2) significant active targeting effect caused by conjugated AS1411 aptamers; and 3) excellent long-term compatibility by incorporation of TPGS. Therefore, with simple preparation procedures and excellent bioproperties, the new functionalized Apt-pD-NPs could maximally increase the local effective drug concentration on tumor sites, achieving enhanced treatment effectiveness and minimizing side effects. In a word, the robust DTX-loaded Apt-pD-NPs could be used as potential nanotherapeutics for cervical cancer treatment, and the aptamer–polydopamine modification strategy could be a promising method for active targeting of cancer therapy with simple procedures. Keywords: dopamine, AS1411 aptamer, active targeting, polymeric NPs, enhanced cervical chemotherapyXu GJYu XHZhang JXSheng YCLiu GTao WMei LDove Medical PressarticleDopamineAS1411 AptamerActive targetingPolymeric NPsEnhanced cervical chemotherapyMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2016, Iss default, Pp 2953-2965 (2016)
institution DOAJ
collection DOAJ
language EN
topic Dopamine
AS1411 Aptamer
Active targeting
Polymeric NPs
Enhanced cervical chemotherapy
Medicine (General)
R5-920
spellingShingle Dopamine
AS1411 Aptamer
Active targeting
Polymeric NPs
Enhanced cervical chemotherapy
Medicine (General)
R5-920
Xu GJ
Yu XH
Zhang JX
Sheng YC
Liu G
Tao W
Mei L
Robust aptamer–polydopamine-functionalized M-PLGA–TPGS nanoparticles for targeted delivery of docetaxel and enhanced cervical cancer therapy
description Guojun Xu,1–3,* Xinghua Yu,2,* Jinxie Zhang,1,2,* Yingchao Sheng,4 Gan Liu,2 Wei Tao,1,2 Lin Mei1,2 1School of Life Sciences, Tsinghua University, Beijing, 2Graduate School at Shenzhen, Tsinghua University, Shenzhen, 3School of Materials Science and Engineering, Tsinghua University, Beijing, 4Department of Orthopedic Surgery, Changshu Hospital of TCM, Changshu, People’s Republic of China *These authors contributed equally to this work Abstract: One limitation of current biodegradable polymeric nanoparticles (NPs) is the contradiction between functional modification and maintaining formerly excellent bioproperties with simple procedures. Here, we reported a robust aptamer–polydopamine-functionalized mannitol-functionalized poly(lactide-co-glycolide) (M-PLGA)–D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) nanoformulation (Apt-pD-NPs) for the delivery of docetaxel (DTX) with enhanced cervical cancer therapy effects. The novel DTX-loaded Apt-pD-NPs possess satisfactory advantages: 1) increased drug loading content and encapsulation efficiency induced by star-shaped copolymer M-PLGA–TPGS; 2) significant active targeting effect caused by conjugated AS1411 aptamers; and 3) excellent long-term compatibility by incorporation of TPGS. Therefore, with simple preparation procedures and excellent bioproperties, the new functionalized Apt-pD-NPs could maximally increase the local effective drug concentration on tumor sites, achieving enhanced treatment effectiveness and minimizing side effects. In a word, the robust DTX-loaded Apt-pD-NPs could be used as potential nanotherapeutics for cervical cancer treatment, and the aptamer–polydopamine modification strategy could be a promising method for active targeting of cancer therapy with simple procedures. Keywords: dopamine, AS1411 aptamer, active targeting, polymeric NPs, enhanced cervical chemotherapy
format article
author Xu GJ
Yu XH
Zhang JX
Sheng YC
Liu G
Tao W
Mei L
author_facet Xu GJ
Yu XH
Zhang JX
Sheng YC
Liu G
Tao W
Mei L
author_sort Xu GJ
title Robust aptamer–polydopamine-functionalized M-PLGA–TPGS nanoparticles for targeted delivery of docetaxel and enhanced cervical cancer therapy
title_short Robust aptamer–polydopamine-functionalized M-PLGA–TPGS nanoparticles for targeted delivery of docetaxel and enhanced cervical cancer therapy
title_full Robust aptamer–polydopamine-functionalized M-PLGA–TPGS nanoparticles for targeted delivery of docetaxel and enhanced cervical cancer therapy
title_fullStr Robust aptamer–polydopamine-functionalized M-PLGA–TPGS nanoparticles for targeted delivery of docetaxel and enhanced cervical cancer therapy
title_full_unstemmed Robust aptamer–polydopamine-functionalized M-PLGA–TPGS nanoparticles for targeted delivery of docetaxel and enhanced cervical cancer therapy
title_sort robust aptamer–polydopamine-functionalized m-plga–tpgs nanoparticles for targeted delivery of docetaxel and enhanced cervical cancer therapy
publisher Dove Medical Press
publishDate 2016
url https://doaj.org/article/07d40d5fb7d5430eb66e577b51f4bfcc
work_keys_str_mv AT xugj robustaptamerndashpolydopaminefunctionalizedmplgandashtpgsnanoparticlesfortargeteddeliveryofdocetaxelandenhancedcervicalcancertherapy
AT yuxh robustaptamerndashpolydopaminefunctionalizedmplgandashtpgsnanoparticlesfortargeteddeliveryofdocetaxelandenhancedcervicalcancertherapy
AT zhangjx robustaptamerndashpolydopaminefunctionalizedmplgandashtpgsnanoparticlesfortargeteddeliveryofdocetaxelandenhancedcervicalcancertherapy
AT shengyc robustaptamerndashpolydopaminefunctionalizedmplgandashtpgsnanoparticlesfortargeteddeliveryofdocetaxelandenhancedcervicalcancertherapy
AT liug robustaptamerndashpolydopaminefunctionalizedmplgandashtpgsnanoparticlesfortargeteddeliveryofdocetaxelandenhancedcervicalcancertherapy
AT taow robustaptamerndashpolydopaminefunctionalizedmplgandashtpgsnanoparticlesfortargeteddeliveryofdocetaxelandenhancedcervicalcancertherapy
AT meil robustaptamerndashpolydopaminefunctionalizedmplgandashtpgsnanoparticlesfortargeteddeliveryofdocetaxelandenhancedcervicalcancertherapy
_version_ 1718399439485272064

Ejemplares similares