Aversive stimuli bias corticothalamic responses to motivationally significant cues

Making predictions about future rewards or punishments is fundamental to adaptive behavior. These processes are influenced by prior experience. For example, prior exposure to aversive stimuli or stressors changes behavioral responses to negative- and positive-value predictive cues. Here, we demonstr...

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Autores principales:	Federica Lucantonio, Eunyoung Kim, Zhixiao Su, Anna J Chang, Bilal A Bari, Jeremiah Y Cohen
Formato:	article
Lenguaje:	EN
Publicado:	eLife Sciences Publications Ltd 2021
Materias:	reward decision neurophysiology Medicine R Science Q Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/07d54f71e3014a51ae9aad8b5a1b972d
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spelling	oai:doaj.org-article:07d54f71e3014a51ae9aad8b5a1b972d2021-11-05T12:09:34ZAversive stimuli bias corticothalamic responses to motivationally significant cues10.7554/eLife.576342050-084Xe57634https://doaj.org/article/07d54f71e3014a51ae9aad8b5a1b972d2021-11-01T00:00:00Zhttps://elifesciences.org/articles/57634https://doaj.org/toc/2050-084XMaking predictions about future rewards or punishments is fundamental to adaptive behavior. These processes are influenced by prior experience. For example, prior exposure to aversive stimuli or stressors changes behavioral responses to negative- and positive-value predictive cues. Here, we demonstrate a role for medial prefrontal cortex (mPFC) neurons projecting to the paraventricular nucleus of the thalamus (PVT; mPFC→PVT) in this process. We found that a history of aversive stimuli negatively biased behavioral responses to motivationally relevant cues in mice and that this negative bias was associated with hyperactivity in mPFC→PVT neurons during exposure to those cues. Furthermore, artificially mimicking this hyperactive response with selective optogenetic excitation of the same pathway recapitulated the negative behavioral bias induced by aversive stimuli, whereas optogenetic inactivation of mPFC→PVT neurons prevented the development of the negative bias. Together, our results highlight how information flow within the mPFC→PVT circuit is critical for making predictions about motivationally-relevant outcomes as a function of prior experience.Federica LucantonioEunyoung KimZhixiao SuAnna J ChangBilal A BariJeremiah Y CoheneLife Sciences Publications LtdarticlerewarddecisionneurophysiologyMedicineRScienceQBiology (General)QH301-705.5ENeLife, Vol 10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	reward decision neurophysiology Medicine R Science Q Biology (General) QH301-705.5
spellingShingle	reward decision neurophysiology Medicine R Science Q Biology (General) QH301-705.5 Federica Lucantonio Eunyoung Kim Zhixiao Su Anna J Chang Bilal A Bari Jeremiah Y Cohen Aversive stimuli bias corticothalamic responses to motivationally significant cues
description	Making predictions about future rewards or punishments is fundamental to adaptive behavior. These processes are influenced by prior experience. For example, prior exposure to aversive stimuli or stressors changes behavioral responses to negative- and positive-value predictive cues. Here, we demonstrate a role for medial prefrontal cortex (mPFC) neurons projecting to the paraventricular nucleus of the thalamus (PVT; mPFC→PVT) in this process. We found that a history of aversive stimuli negatively biased behavioral responses to motivationally relevant cues in mice and that this negative bias was associated with hyperactivity in mPFC→PVT neurons during exposure to those cues. Furthermore, artificially mimicking this hyperactive response with selective optogenetic excitation of the same pathway recapitulated the negative behavioral bias induced by aversive stimuli, whereas optogenetic inactivation of mPFC→PVT neurons prevented the development of the negative bias. Together, our results highlight how information flow within the mPFC→PVT circuit is critical for making predictions about motivationally-relevant outcomes as a function of prior experience.
format	article
author	Federica Lucantonio Eunyoung Kim Zhixiao Su Anna J Chang Bilal A Bari Jeremiah Y Cohen
author_facet	Federica Lucantonio Eunyoung Kim Zhixiao Su Anna J Chang Bilal A Bari Jeremiah Y Cohen
author_sort	Federica Lucantonio
title	Aversive stimuli bias corticothalamic responses to motivationally significant cues
title_short	Aversive stimuli bias corticothalamic responses to motivationally significant cues
title_full	Aversive stimuli bias corticothalamic responses to motivationally significant cues
title_fullStr	Aversive stimuli bias corticothalamic responses to motivationally significant cues
title_full_unstemmed	Aversive stimuli bias corticothalamic responses to motivationally significant cues
title_sort	aversive stimuli bias corticothalamic responses to motivationally significant cues
publisher	eLife Sciences Publications Ltd
publishDate	2021
url	https://doaj.org/article/07d54f71e3014a51ae9aad8b5a1b972d
work_keys_str_mv	AT federicalucantonio aversivestimulibiascorticothalamicresponsestomotivationallysignificantcues AT eunyoungkim aversivestimulibiascorticothalamicresponsestomotivationallysignificantcues AT zhixiaosu aversivestimulibiascorticothalamicresponsestomotivationallysignificantcues AT annajchang aversivestimulibiascorticothalamicresponsestomotivationallysignificantcues AT bilalabari aversivestimulibiascorticothalamicresponsestomotivationallysignificantcues AT jeremiahycohen aversivestimulibiascorticothalamicresponsestomotivationallysignificantcues
_version_	1718444267782799360

Aversive stimuli bias corticothalamic responses to motivationally significant cues

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