New approaches in the management of advanced breast cancer – role of combination treatment with liposomal doxorubicin
Iain RJ Macpherson, TR Jeffry EvansBeatson West of Scotland Cancer Centre, Glasgow, United KingdomAbstract: Metastatic breast cancer (MBC) remains a major cause of morbidity and mortality in women worldwide. For three decades doxorubicin, alone or in combination with other cytotoxic agents, has been...
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Dove Medical Press
2009
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oai:doaj.org-article:07d554b863344a4684d716ce24584f3f2021-12-02T04:25:28ZNew approaches in the management of advanced breast cancer – role of combination treatment with liposomal doxorubicin1179-1314https://doaj.org/article/07d554b863344a4684d716ce24584f3f2009-08-01T00:00:00Zhttp://www.dovepress.com/new-approaches-in-the-management-of-advanced-breast-cancer-ndash-role--a3499https://doaj.org/toc/1179-1314Iain RJ Macpherson, TR Jeffry EvansBeatson West of Scotland Cancer Centre, Glasgow, United KingdomAbstract: Metastatic breast cancer (MBC) remains a major cause of morbidity and mortality in women worldwide. For three decades doxorubicin, alone or in combination with other cytotoxic agents, has been a mainstay of systemic therapy for MBC. However, its use is limited by cumulative cardiotoxicity. More recently liposomal formulations of doxorubicin have been developed which exhibit equal efficacy but reduced cardiotoxicity in comparison to conventional doxorubicin. The novel toxicity profile of liposomal doxorubicins has prompted their evaluation with various cytotoxic agents in patients with MBC. In addition, their favorable cardiac safety profile has prompted re-evaluation of concomitant therapy with doxorubicin and trastuzumab, a regimen of proven efficacy in MBC but previously considered to be associated with significant cardiotoxicity. We review clinical trial data addressing combination therapy with both pegylated and non-pegylated liposomal doxorubicin in patients with MBC.Keywords: breast cancer, anthracycline, liposome-encapsulated doxorubicin, pegylated liposomal doxorubicin, cardiotoxicity Iain RJ MacphersonTR Jeffry EvansDove Medical PressarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENBreast Cancer: Targets and Therapy, Vol 2009, Iss default, Pp 1-18 (2009) |
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DOAJ |
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EN |
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 |
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Iain RJ Macpherson TR Jeffry Evans New approaches in the management of advanced breast cancer – role of combination treatment with liposomal doxorubicin |
| description |
Iain RJ Macpherson, TR Jeffry EvansBeatson West of Scotland Cancer Centre, Glasgow, United KingdomAbstract: Metastatic breast cancer (MBC) remains a major cause of morbidity and mortality in women worldwide. For three decades doxorubicin, alone or in combination with other cytotoxic agents, has been a mainstay of systemic therapy for MBC. However, its use is limited by cumulative cardiotoxicity. More recently liposomal formulations of doxorubicin have been developed which exhibit equal efficacy but reduced cardiotoxicity in comparison to conventional doxorubicin. The novel toxicity profile of liposomal doxorubicins has prompted their evaluation with various cytotoxic agents in patients with MBC. In addition, their favorable cardiac safety profile has prompted re-evaluation of concomitant therapy with doxorubicin and trastuzumab, a regimen of proven efficacy in MBC but previously considered to be associated with significant cardiotoxicity. We review clinical trial data addressing combination therapy with both pegylated and non-pegylated liposomal doxorubicin in patients with MBC.Keywords: breast cancer, anthracycline, liposome-encapsulated doxorubicin, pegylated liposomal doxorubicin, cardiotoxicity |
| format |
article |
| author |
Iain RJ Macpherson TR Jeffry Evans |
| author_facet |
Iain RJ Macpherson TR Jeffry Evans |
| author_sort |
Iain RJ Macpherson |
| title |
New approaches in the management of advanced breast cancer – role of combination treatment with liposomal doxorubicin |
| title_short |
New approaches in the management of advanced breast cancer – role of combination treatment with liposomal doxorubicin |
| title_full |
New approaches in the management of advanced breast cancer – role of combination treatment with liposomal doxorubicin |
| title_fullStr |
New approaches in the management of advanced breast cancer – role of combination treatment with liposomal doxorubicin |
| title_full_unstemmed |
New approaches in the management of advanced breast cancer – role of combination treatment with liposomal doxorubicin |
| title_sort |
new approaches in the management of advanced breast cancer – role of combination treatment with liposomal doxorubicin |
| publisher |
Dove Medical Press |
| publishDate |
2009 |
| url |
https://doaj.org/article/07d554b863344a4684d716ce24584f3f |
| work_keys_str_mv |
AT iainrjmacpherson newapproachesinthemanagementofadvancedbreastcancerampndashroleofcombinationtreatmentwithliposomaldoxorubicin AT trjeffryevans newapproachesinthemanagementofadvancedbreastcancerampndashroleofcombinationtreatmentwithliposomaldoxorubicin |
| _version_ |
1718401229200031744 |