Neonicotinoids can cause arrested pupal ecdysis in Lepidoptera

Abstract Recently, we reported a novel mode of action in monarch butterfly (Danaus plexippus) larvae exposed to neonicotinoid insecticides: arrest in pupal ecdysis following successful larval ecdysis. In this paper, we explore arrested pupal ecdysis in greater detail and propose adverse outcome path...

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Autores principales:	Niranjana Krishnan, Russell A. Jurenka, Steven P. Bradbury
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/07d63c497d964bc5bb5d4b18ad212f86
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spelling	oai:doaj.org-article:07d63c497d964bc5bb5d4b18ad212f862021-12-02T18:49:34ZNeonicotinoids can cause arrested pupal ecdysis in Lepidoptera10.1038/s41598-021-95284-02045-2322https://doaj.org/article/07d63c497d964bc5bb5d4b18ad212f862021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95284-0https://doaj.org/toc/2045-2322Abstract Recently, we reported a novel mode of action in monarch butterfly (Danaus plexippus) larvae exposed to neonicotinoid insecticides: arrest in pupal ecdysis following successful larval ecdysis. In this paper, we explore arrested pupal ecdysis in greater detail and propose adverse outcome pathways to explain how neonicotinoids cause this effect. Using imidacloprid as a model compound, we determined that final-instar monarchs, corn earworms (Helicoverpa zea), and wax moths (Galleria mellonella) showed high susceptibility to arrested pupal ecdysis while painted ladies (Vanessa cardui) and red admirals (Vanessa atalanta) showed low susceptibility. Fall armyworms (Spodoptera frugiperda) and European corn borers (Ostrinia nubilalis) were recalcitrant. All larvae with arrested ecdysis developed pupal cuticle, but with incomplete shedding of larval cuticle and unexpanded pupal appendages; corn earworm larvae successfully developed into adults with unexpanded appendages. Delayed initiation of pupal ecdysis was also observed with treated larvae. Imidacloprid exposure was required at least 26 h prior to pupal ecdysis to disrupt the molt. These observations suggest neonicotinoids may disrupt the function of crustacean cardioactive peptide (CCAP) neurons, either by directly acting on their nicotinic acetylcholine receptors or by acting on receptors of inhibitory neurons that regulate CCAP activity.Niranjana KrishnanRussell A. JurenkaSteven P. BradburyNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Niranjana Krishnan Russell A. Jurenka Steven P. Bradbury Neonicotinoids can cause arrested pupal ecdysis in Lepidoptera
description	Abstract Recently, we reported a novel mode of action in monarch butterfly (Danaus plexippus) larvae exposed to neonicotinoid insecticides: arrest in pupal ecdysis following successful larval ecdysis. In this paper, we explore arrested pupal ecdysis in greater detail and propose adverse outcome pathways to explain how neonicotinoids cause this effect. Using imidacloprid as a model compound, we determined that final-instar monarchs, corn earworms (Helicoverpa zea), and wax moths (Galleria mellonella) showed high susceptibility to arrested pupal ecdysis while painted ladies (Vanessa cardui) and red admirals (Vanessa atalanta) showed low susceptibility. Fall armyworms (Spodoptera frugiperda) and European corn borers (Ostrinia nubilalis) were recalcitrant. All larvae with arrested ecdysis developed pupal cuticle, but with incomplete shedding of larval cuticle and unexpanded pupal appendages; corn earworm larvae successfully developed into adults with unexpanded appendages. Delayed initiation of pupal ecdysis was also observed with treated larvae. Imidacloprid exposure was required at least 26 h prior to pupal ecdysis to disrupt the molt. These observations suggest neonicotinoids may disrupt the function of crustacean cardioactive peptide (CCAP) neurons, either by directly acting on their nicotinic acetylcholine receptors or by acting on receptors of inhibitory neurons that regulate CCAP activity.
format	article
author	Niranjana Krishnan Russell A. Jurenka Steven P. Bradbury
author_facet	Niranjana Krishnan Russell A. Jurenka Steven P. Bradbury
author_sort	Niranjana Krishnan
title	Neonicotinoids can cause arrested pupal ecdysis in Lepidoptera
title_short	Neonicotinoids can cause arrested pupal ecdysis in Lepidoptera
title_full	Neonicotinoids can cause arrested pupal ecdysis in Lepidoptera
title_fullStr	Neonicotinoids can cause arrested pupal ecdysis in Lepidoptera
title_full_unstemmed	Neonicotinoids can cause arrested pupal ecdysis in Lepidoptera
title_sort	neonicotinoids can cause arrested pupal ecdysis in lepidoptera
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/07d63c497d964bc5bb5d4b18ad212f86
work_keys_str_mv	AT niranjanakrishnan neonicotinoidscancausearrestedpupalecdysisinlepidoptera AT russellajurenka neonicotinoidscancausearrestedpupalecdysisinlepidoptera AT stevenpbradbury neonicotinoidscancausearrestedpupalecdysisinlepidoptera
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Neonicotinoids can cause arrested pupal ecdysis in Lepidoptera

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