Adjustment for index event bias in genome-wide association studies of subsequent events

Different from GWAS for susceptibility to disease, GWAS for prognosis or survival may be vulnerable to selection bias. Here, Dudbridge et al present an approach to reduce index event bias in simulated and realistic situations, and apply it to GWAS of survival with idiopathic pulmonary fibrosis and C...

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Autores principales:	Frank Dudbridge, Richard J. Allen, Nuala A. Sheehan, A. Floriaan Schmidt, James C. Lee, R. Gisli Jenkins, Louise V. Wain, Aroon D. Hingorani, Riyaz S. Patel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/07d691978fe9471d8ffc03da2ac55ffb
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spelling	oai:doaj.org-article:07d691978fe9471d8ffc03da2ac55ffb2021-12-02T17:01:50ZAdjustment for index event bias in genome-wide association studies of subsequent events10.1038/s41467-019-09381-w2041-1723https://doaj.org/article/07d691978fe9471d8ffc03da2ac55ffb2019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09381-whttps://doaj.org/toc/2041-1723Different from GWAS for susceptibility to disease, GWAS for prognosis or survival may be vulnerable to selection bias. Here, Dudbridge et al present an approach to reduce index event bias in simulated and realistic situations, and apply it to GWAS of survival with idiopathic pulmonary fibrosis and Crohn’s disease prognosis.Frank DudbridgeRichard J. AllenNuala A. SheehanA. Floriaan SchmidtJames C. LeeR. Gisli JenkinsLouise V. WainAroon D. HingoraniRiyaz S. PatelNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Frank Dudbridge Richard J. Allen Nuala A. Sheehan A. Floriaan Schmidt James C. Lee R. Gisli Jenkins Louise V. Wain Aroon D. Hingorani Riyaz S. Patel Adjustment for index event bias in genome-wide association studies of subsequent events
description	Different from GWAS for susceptibility to disease, GWAS for prognosis or survival may be vulnerable to selection bias. Here, Dudbridge et al present an approach to reduce index event bias in simulated and realistic situations, and apply it to GWAS of survival with idiopathic pulmonary fibrosis and Crohn’s disease prognosis.
format	article
author	Frank Dudbridge Richard J. Allen Nuala A. Sheehan A. Floriaan Schmidt James C. Lee R. Gisli Jenkins Louise V. Wain Aroon D. Hingorani Riyaz S. Patel
author_facet	Frank Dudbridge Richard J. Allen Nuala A. Sheehan A. Floriaan Schmidt James C. Lee R. Gisli Jenkins Louise V. Wain Aroon D. Hingorani Riyaz S. Patel
author_sort	Frank Dudbridge
title	Adjustment for index event bias in genome-wide association studies of subsequent events
title_short	Adjustment for index event bias in genome-wide association studies of subsequent events
title_full	Adjustment for index event bias in genome-wide association studies of subsequent events
title_fullStr	Adjustment for index event bias in genome-wide association studies of subsequent events
title_full_unstemmed	Adjustment for index event bias in genome-wide association studies of subsequent events
title_sort	adjustment for index event bias in genome-wide association studies of subsequent events
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/07d691978fe9471d8ffc03da2ac55ffb
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Adjustment for index event bias in genome-wide association studies of subsequent events

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