Association of coagulation dysfunction with cardiac injury among hospitalized patients with COVID-19
Abstract Cardiac injury is a common complication of the coronavirus disease 2019 (COVID-19), and is associated with adverse clinical outcomes. In this study, we aimed to reveal the association of cardiac injury with coagulation dysfunction. We enrolled 181 consecutive patients who were hospitalized...
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Nature Portfolio
2021
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oai:doaj.org-article:07d90cada40643ac98b95f0d399884412021-12-02T15:54:09ZAssociation of coagulation dysfunction with cardiac injury among hospitalized patients with COVID-1910.1038/s41598-021-83822-92045-2322https://doaj.org/article/07d90cada40643ac98b95f0d399884412021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83822-9https://doaj.org/toc/2045-2322Abstract Cardiac injury is a common complication of the coronavirus disease 2019 (COVID-19), and is associated with adverse clinical outcomes. In this study, we aimed to reveal the association of cardiac injury with coagulation dysfunction. We enrolled 181 consecutive patients who were hospitalized with COVID-19, and studied the clinical characteristics and outcome of these patients. Cardiac biomarkers high-sensitivity troponin I (hs-cTnI), myohemoglobin and creatine kinase-myocardial band (CK-MB) were assessed in all patients. The clinical outcomes were defined as hospital discharge or death. The median age of the study cohort was 55 (IQR, 46–65) years, and 102 (56.4%) were males. Forty-two of the 181 patients (23.2%) had cardiac injury. Old age, high leukocyte count, and high levels of aspartate transaminase (AST), D-dimer and serum ferritin were significantly associated with cardiac injury. Multivariate regression analysis revealed old age and elevated D-dimer levels as being strong risk predictors of in-hospital mortality. Interleukin 6 (IL6) levels were comparable in patients with or without cardiac injury. Serial observations of coagulation parameters demonstrated highly synchronous alterations of D-dimer along with progression to cardiac injury. Cardiac injury is a common complication of COVID-19 and is an independent risk factor for in-hospital mortality. Old age, high leukocyte count, and high levels of AST, D-dimer and serum ferritin are significantly associated with cardiac injury, whereas IL6 are not. Therefore, the pathogenesis of cardiac injury in COVID-19 may be primarily due to coagulation dysfunction along with microvascular injury.Liang ChenWei HuXiaoxiao GuoPing ZhaoJia TangYuwei GuNinghao HuangChao WangAn CuiDian ZhangLinjie HuYi FengShengshou HuMingquan ChenFirat DuruChenglong XiongNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021) |
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Medicine R Science Q |
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Medicine R Science Q Liang Chen Wei Hu Xiaoxiao Guo Ping Zhao Jia Tang Yuwei Gu Ninghao Huang Chao Wang An Cui Dian Zhang Linjie Hu Yi Feng Shengshou Hu Mingquan Chen Firat Duru Chenglong Xiong Association of coagulation dysfunction with cardiac injury among hospitalized patients with COVID-19 |
| description |
Abstract Cardiac injury is a common complication of the coronavirus disease 2019 (COVID-19), and is associated with adverse clinical outcomes. In this study, we aimed to reveal the association of cardiac injury with coagulation dysfunction. We enrolled 181 consecutive patients who were hospitalized with COVID-19, and studied the clinical characteristics and outcome of these patients. Cardiac biomarkers high-sensitivity troponin I (hs-cTnI), myohemoglobin and creatine kinase-myocardial band (CK-MB) were assessed in all patients. The clinical outcomes were defined as hospital discharge or death. The median age of the study cohort was 55 (IQR, 46–65) years, and 102 (56.4%) were males. Forty-two of the 181 patients (23.2%) had cardiac injury. Old age, high leukocyte count, and high levels of aspartate transaminase (AST), D-dimer and serum ferritin were significantly associated with cardiac injury. Multivariate regression analysis revealed old age and elevated D-dimer levels as being strong risk predictors of in-hospital mortality. Interleukin 6 (IL6) levels were comparable in patients with or without cardiac injury. Serial observations of coagulation parameters demonstrated highly synchronous alterations of D-dimer along with progression to cardiac injury. Cardiac injury is a common complication of COVID-19 and is an independent risk factor for in-hospital mortality. Old age, high leukocyte count, and high levels of AST, D-dimer and serum ferritin are significantly associated with cardiac injury, whereas IL6 are not. Therefore, the pathogenesis of cardiac injury in COVID-19 may be primarily due to coagulation dysfunction along with microvascular injury. |
| format |
article |
| author |
Liang Chen Wei Hu Xiaoxiao Guo Ping Zhao Jia Tang Yuwei Gu Ninghao Huang Chao Wang An Cui Dian Zhang Linjie Hu Yi Feng Shengshou Hu Mingquan Chen Firat Duru Chenglong Xiong |
| author_facet |
Liang Chen Wei Hu Xiaoxiao Guo Ping Zhao Jia Tang Yuwei Gu Ninghao Huang Chao Wang An Cui Dian Zhang Linjie Hu Yi Feng Shengshou Hu Mingquan Chen Firat Duru Chenglong Xiong |
| author_sort |
Liang Chen |
| title |
Association of coagulation dysfunction with cardiac injury among hospitalized patients with COVID-19 |
| title_short |
Association of coagulation dysfunction with cardiac injury among hospitalized patients with COVID-19 |
| title_full |
Association of coagulation dysfunction with cardiac injury among hospitalized patients with COVID-19 |
| title_fullStr |
Association of coagulation dysfunction with cardiac injury among hospitalized patients with COVID-19 |
| title_full_unstemmed |
Association of coagulation dysfunction with cardiac injury among hospitalized patients with COVID-19 |
| title_sort |
association of coagulation dysfunction with cardiac injury among hospitalized patients with covid-19 |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/07d90cada40643ac98b95f0d39988441 |
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