Inhibiting breast cancer by targeting the thromboxane A2 pathway

Breast cancer: Pathway target identified The identification of a signaling pathway connected to the progression of breast cancer could prove a valuable therapeutic target. The breast cancer treatment tamoxifen, although successful, is limited to certain tumor types, and so the search is on to pinpoi...

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Autores principales:	Haitao Li, Mee-Hyun Lee, Kangdong Liu, Ting Wang, Mengqiu Song, Yaping Han, Ke Yao, Hua Xie, Feng Zhu, Michael Grossmann, Margot P. Cleary, Wei Chen, Ann M. Bode, Zigang Dong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/07d9df38e8884ed990883481bc3a6b23
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spelling	oai:doaj.org-article:07d9df38e8884ed990883481bc3a6b232021-12-02T16:05:45ZInhibiting breast cancer by targeting the thromboxane A2 pathway10.1038/s41698-017-0011-42397-768Xhttps://doaj.org/article/07d9df38e8884ed990883481bc3a6b232017-04-01T00:00:00Zhttps://doi.org/10.1038/s41698-017-0011-4https://doaj.org/toc/2397-768XBreast cancer: Pathway target identified The identification of a signaling pathway connected to the progression of breast cancer could prove a valuable therapeutic target. The breast cancer treatment tamoxifen, although successful, is limited to certain tumor types, and so the search is on to pinpoint molecular targets that are ubiquitous across breast cancers. Zigang Dong at the University of Minnesota, US, and co-workers identified that the thromboxane A2 (TXA2) pathway is highly-expressed in human breast tumors and premalignant lesions. Further examination showed that TXA2 is crucial for tumor cell growth and metastasis. When the researchers knocked-out TXA2 production in mouse models, this suppressed both the formation and spread of tumors. The team advise caution because TXA2 is also required for wound healing and other key processes, although short-term bursts of pathway suppression may be an option for breast cancer therapy.Haitao LiMee-Hyun LeeKangdong LiuTing WangMengqiu SongYaping HanKe YaoHua XieFeng ZhuMichael GrossmannMargot P. ClearyWei ChenAnn M. BodeZigang DongNature PortfolioarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Precision Oncology, Vol 1, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Haitao Li Mee-Hyun Lee Kangdong Liu Ting Wang Mengqiu Song Yaping Han Ke Yao Hua Xie Feng Zhu Michael Grossmann Margot P. Cleary Wei Chen Ann M. Bode Zigang Dong Inhibiting breast cancer by targeting the thromboxane A2 pathway
description	Breast cancer: Pathway target identified The identification of a signaling pathway connected to the progression of breast cancer could prove a valuable therapeutic target. The breast cancer treatment tamoxifen, although successful, is limited to certain tumor types, and so the search is on to pinpoint molecular targets that are ubiquitous across breast cancers. Zigang Dong at the University of Minnesota, US, and co-workers identified that the thromboxane A2 (TXA2) pathway is highly-expressed in human breast tumors and premalignant lesions. Further examination showed that TXA2 is crucial for tumor cell growth and metastasis. When the researchers knocked-out TXA2 production in mouse models, this suppressed both the formation and spread of tumors. The team advise caution because TXA2 is also required for wound healing and other key processes, although short-term bursts of pathway suppression may be an option for breast cancer therapy.
format	article
author	Haitao Li Mee-Hyun Lee Kangdong Liu Ting Wang Mengqiu Song Yaping Han Ke Yao Hua Xie Feng Zhu Michael Grossmann Margot P. Cleary Wei Chen Ann M. Bode Zigang Dong
author_facet	Haitao Li Mee-Hyun Lee Kangdong Liu Ting Wang Mengqiu Song Yaping Han Ke Yao Hua Xie Feng Zhu Michael Grossmann Margot P. Cleary Wei Chen Ann M. Bode Zigang Dong
author_sort	Haitao Li
title	Inhibiting breast cancer by targeting the thromboxane A2 pathway
title_short	Inhibiting breast cancer by targeting the thromboxane A2 pathway
title_full	Inhibiting breast cancer by targeting the thromboxane A2 pathway
title_fullStr	Inhibiting breast cancer by targeting the thromboxane A2 pathway
title_full_unstemmed	Inhibiting breast cancer by targeting the thromboxane A2 pathway
title_sort	inhibiting breast cancer by targeting the thromboxane a2 pathway
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/07d9df38e8884ed990883481bc3a6b23
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Inhibiting breast cancer by targeting the thromboxane A2 pathway

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