Poliovirus intrahost evolution is required to overcome tissue-specific innate immune responses

RNA viruses, such as polioviruses, have a great evolutionary capacity and can adapt quickly during infection. Here, the authors show that poliovirus infection in mice requires adaptation to innate immune microenvironments encountered in different tissues.

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Detalles Bibliográficos
Autores principales: Yinghong Xiao, Patrick Timothy Dolan, Elizabeth Faul Goldstein, Min Li, Mikhail Farkov, Leonid Brodsky, Raul Andino
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/07dbb9d5bd994988b91e09463962e406
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Descripción
Sumario:RNA viruses, such as polioviruses, have a great evolutionary capacity and can adapt quickly during infection. Here, the authors show that poliovirus infection in mice requires adaptation to innate immune microenvironments encountered in different tissues.