Poliovirus intrahost evolution is required to overcome tissue-specific innate immune responses

Poliovirus intrahost evolution is required to overcome tissue-specific innate immune responses

RNA viruses, such as polioviruses, have a great evolutionary capacity and can adapt quickly during infection. Here, the authors show that poliovirus infection in mice requires adaptation to innate immune microenvironments encountered in different tissues.

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Autores principales: Yinghong Xiao, Patrick Timothy Dolan, Elizabeth Faul Goldstein, Min Li, Mikhail Farkov, Leonid Brodsky, Raul Andino
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Q
Acceso en línea:https://doaj.org/article/07dbb9d5bd994988b91e09463962e406
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spelling oai:doaj.org-article:07dbb9d5bd994988b91e09463962e4062021-12-02T14:41:20ZPoliovirus intrahost evolution is required to overcome tissue-specific innate immune responses10.1038/s41467-017-00354-52041-1723https://doaj.org/article/07dbb9d5bd994988b91e09463962e4062017-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00354-5https://doaj.org/toc/2041-1723RNA viruses, such as polioviruses, have a great evolutionary capacity and can adapt quickly during infection. Here, the authors show that poliovirus infection in mice requires adaptation to innate immune microenvironments encountered in different tissues.Yinghong XiaoPatrick Timothy DolanElizabeth Faul GoldsteinMin LiMikhail FarkovLeonid BrodskyRaul AndinoNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yinghong Xiao
Patrick Timothy Dolan
Elizabeth Faul Goldstein
Min Li
Mikhail Farkov
Leonid Brodsky
Raul Andino
Poliovirus intrahost evolution is required to overcome tissue-specific innate immune responses
description RNA viruses, such as polioviruses, have a great evolutionary capacity and can adapt quickly during infection. Here, the authors show that poliovirus infection in mice requires adaptation to innate immune microenvironments encountered in different tissues.
format article
author Yinghong Xiao
Patrick Timothy Dolan
Elizabeth Faul Goldstein
Min Li
Mikhail Farkov
Leonid Brodsky
Raul Andino
author_facet Yinghong Xiao
Patrick Timothy Dolan
Elizabeth Faul Goldstein
Min Li
Mikhail Farkov
Leonid Brodsky
Raul Andino
author_sort Yinghong Xiao
title Poliovirus intrahost evolution is required to overcome tissue-specific innate immune responses
title_short Poliovirus intrahost evolution is required to overcome tissue-specific innate immune responses
title_full Poliovirus intrahost evolution is required to overcome tissue-specific innate immune responses
title_fullStr Poliovirus intrahost evolution is required to overcome tissue-specific innate immune responses
title_full_unstemmed Poliovirus intrahost evolution is required to overcome tissue-specific innate immune responses
title_sort poliovirus intrahost evolution is required to overcome tissue-specific innate immune responses
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/07dbb9d5bd994988b91e09463962e406
work_keys_str_mv AT yinghongxiao poliovirusintrahostevolutionisrequiredtoovercometissuespecificinnateimmuneresponses
AT patricktimothydolan poliovirusintrahostevolutionisrequiredtoovercometissuespecificinnateimmuneresponses
AT elizabethfaulgoldstein poliovirusintrahostevolutionisrequiredtoovercometissuespecificinnateimmuneresponses
AT minli poliovirusintrahostevolutionisrequiredtoovercometissuespecificinnateimmuneresponses
AT mikhailfarkov poliovirusintrahostevolutionisrequiredtoovercometissuespecificinnateimmuneresponses
AT leonidbrodsky poliovirusintrahostevolutionisrequiredtoovercometissuespecificinnateimmuneresponses
AT raulandino poliovirusintrahostevolutionisrequiredtoovercometissuespecificinnateimmuneresponses
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