Hepatic metabolic effects of Curcuma longa extract supplement in high-fructose and saturated fat fed rats

Abstract The metabolic effects of an oral supplementation with a Curcuma longa extract, at a dose nutritionally relevant with common human use, on hepatic metabolism in rats fed a high fructose and saturated fatty acid (HFS) diet was evaluated. High-resolution magic-angle spinning NMR and GC/MS in c...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Fabrice Tranchida, Zo Rakotoniaina, Laetitia Shintu, Léopold Tchiakpe, Valérie Deyris, Mehdi Yemloul, Pierre Stocker, Nicolas Vidal, Odile Rimet, Abel Hiol, Stefano Caldarelli
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/07dc5c88496a490d9b3a4701d6ef890d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:07dc5c88496a490d9b3a4701d6ef890d
record_format	dspace
spelling	oai:doaj.org-article:07dc5c88496a490d9b3a4701d6ef890d2021-12-02T16:08:19ZHepatic metabolic effects of Curcuma longa extract supplement in high-fructose and saturated fat fed rats10.1038/s41598-017-06220-02045-2322https://doaj.org/article/07dc5c88496a490d9b3a4701d6ef890d2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06220-0https://doaj.org/toc/2045-2322Abstract The metabolic effects of an oral supplementation with a Curcuma longa extract, at a dose nutritionally relevant with common human use, on hepatic metabolism in rats fed a high fructose and saturated fatty acid (HFS) diet was evaluated. High-resolution magic-angle spinning NMR and GC/MS in combination with multivariate analysis have been employed to characterize the NMR metabolite profiles and fatty acid composition of liver tissue respectively. The results showed a clear discrimination between HFS groups and controls involving metabolites such as glucose, glycogen, amino acids, acetate, choline, lysophosphatidylcholine, phosphatidylethanolamine, and β-hydroxybutyrate as well as an increase of MUFAs and a decrease of n-6 and n-3 PUFAs. Although the administration of CL did not counteract deleterious effects of the HFS diet, some metabolites, namely some n-6 PUFA and n-3 PUFA, and betaine were found to increase significantly in liver samples from rats having received extract of curcuma compared to those fed the HFS diet alone. This result suggests that curcuminoids may affect the transmethylation pathway and/or osmotic regulation. CL extract supplementation in rats appears to increase some of the natural defences preventing the development of fatty liver by acting on the choline metabolism to increase fat export from the liver.Fabrice TranchidaZo RakotoniainaLaetitia ShintuLéopold TchiakpeValérie DeyrisMehdi YemloulPierre StockerNicolas VidalOdile RimetAbel HiolStefano CaldarelliNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Fabrice Tranchida Zo Rakotoniaina Laetitia Shintu Léopold Tchiakpe Valérie Deyris Mehdi Yemloul Pierre Stocker Nicolas Vidal Odile Rimet Abel Hiol Stefano Caldarelli Hepatic metabolic effects of Curcuma longa extract supplement in high-fructose and saturated fat fed rats
description	Abstract The metabolic effects of an oral supplementation with a Curcuma longa extract, at a dose nutritionally relevant with common human use, on hepatic metabolism in rats fed a high fructose and saturated fatty acid (HFS) diet was evaluated. High-resolution magic-angle spinning NMR and GC/MS in combination with multivariate analysis have been employed to characterize the NMR metabolite profiles and fatty acid composition of liver tissue respectively. The results showed a clear discrimination between HFS groups and controls involving metabolites such as glucose, glycogen, amino acids, acetate, choline, lysophosphatidylcholine, phosphatidylethanolamine, and β-hydroxybutyrate as well as an increase of MUFAs and a decrease of n-6 and n-3 PUFAs. Although the administration of CL did not counteract deleterious effects of the HFS diet, some metabolites, namely some n-6 PUFA and n-3 PUFA, and betaine were found to increase significantly in liver samples from rats having received extract of curcuma compared to those fed the HFS diet alone. This result suggests that curcuminoids may affect the transmethylation pathway and/or osmotic regulation. CL extract supplementation in rats appears to increase some of the natural defences preventing the development of fatty liver by acting on the choline metabolism to increase fat export from the liver.
format	article
author	Fabrice Tranchida Zo Rakotoniaina Laetitia Shintu Léopold Tchiakpe Valérie Deyris Mehdi Yemloul Pierre Stocker Nicolas Vidal Odile Rimet Abel Hiol Stefano Caldarelli
author_facet	Fabrice Tranchida Zo Rakotoniaina Laetitia Shintu Léopold Tchiakpe Valérie Deyris Mehdi Yemloul Pierre Stocker Nicolas Vidal Odile Rimet Abel Hiol Stefano Caldarelli
author_sort	Fabrice Tranchida
title	Hepatic metabolic effects of Curcuma longa extract supplement in high-fructose and saturated fat fed rats
title_short	Hepatic metabolic effects of Curcuma longa extract supplement in high-fructose and saturated fat fed rats
title_full	Hepatic metabolic effects of Curcuma longa extract supplement in high-fructose and saturated fat fed rats
title_fullStr	Hepatic metabolic effects of Curcuma longa extract supplement in high-fructose and saturated fat fed rats
title_full_unstemmed	Hepatic metabolic effects of Curcuma longa extract supplement in high-fructose and saturated fat fed rats
title_sort	hepatic metabolic effects of curcuma longa extract supplement in high-fructose and saturated fat fed rats
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/07dc5c88496a490d9b3a4701d6ef890d
work_keys_str_mv	AT fabricetranchida hepaticmetaboliceffectsofcurcumalongaextractsupplementinhighfructoseandsaturatedfatfedrats AT zorakotoniaina hepaticmetaboliceffectsofcurcumalongaextractsupplementinhighfructoseandsaturatedfatfedrats AT laetitiashintu hepaticmetaboliceffectsofcurcumalongaextractsupplementinhighfructoseandsaturatedfatfedrats AT leopoldtchiakpe hepaticmetaboliceffectsofcurcumalongaextractsupplementinhighfructoseandsaturatedfatfedrats AT valeriedeyris hepaticmetaboliceffectsofcurcumalongaextractsupplementinhighfructoseandsaturatedfatfedrats AT mehdiyemloul hepaticmetaboliceffectsofcurcumalongaextractsupplementinhighfructoseandsaturatedfatfedrats AT pierrestocker hepaticmetaboliceffectsofcurcumalongaextractsupplementinhighfructoseandsaturatedfatfedrats AT nicolasvidal hepaticmetaboliceffectsofcurcumalongaextractsupplementinhighfructoseandsaturatedfatfedrats AT odilerimet hepaticmetaboliceffectsofcurcumalongaextractsupplementinhighfructoseandsaturatedfatfedrats AT abelhiol hepaticmetaboliceffectsofcurcumalongaextractsupplementinhighfructoseandsaturatedfatfedrats AT stefanocaldarelli hepaticmetaboliceffectsofcurcumalongaextractsupplementinhighfructoseandsaturatedfatfedrats
_version_	1718384512367329280

Hepatic metabolic effects of Curcuma longa extract supplement in high-fructose and saturated fat fed rats

Ejemplares similares