Stepwise encapsulation and controlled two-stage release system for cis-Diamminediiodoplatinum

Yun Chen,1,* Qian Li,1,2,* Qingsheng Wu1 1Department of Chemistry, Key Laboratory of Yangtze River Water Environment, Ministry of Education, Tongji University, Shanghai; 2Shanghai Institute of Quality Inspection and Technical Research, Shanghai, People’s Republic of China *These author...

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Autores principales:	Chen Y, Li Q, Wu QS
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/07e055b932104ae2ac395e003fc1ba5e
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spelling	oai:doaj.org-article:07e055b932104ae2ac395e003fc1ba5e2021-12-02T02:38:20ZStepwise encapsulation and controlled two-stage release system for cis-Diamminediiodoplatinum1178-2013https://doaj.org/article/07e055b932104ae2ac395e003fc1ba5e2014-06-01T00:00:00Zhttp://www.dovepress.com/stepwise-encapsulation-and-controlled-two-stage-release-system-for-cis-a17405https://doaj.org/toc/1178-2013 Yun Chen,1,* Qian Li,1,2,* Qingsheng Wu1 1Department of Chemistry, Key Laboratory of Yangtze River Water Environment, Ministry of Education, Tongji University, Shanghai; 2Shanghai Institute of Quality Inspection and Technical Research, Shanghai, People’s Republic of China *These authors contributed equally to this work Abstract: cis-Diamminediiodoplatinum (cis-DIDP) is a cisplatin-like anticancer drug with higher anticancer activity, but lower stability and price than cisplatin. In this study, a cis-DIDP carrier system based on micro-sized stearic acid was prepared by an emulsion solvent evaporation method. The maximum drug loading capacity of cis-DIDP-loaded solid lipid nanoparticles was 22.03%, and their encapsulation efficiency was 97.24%. In vitro drug release in phosphate-buffered saline (pH =7.4) at 37.5°C exhibited a unique two-stage process, which could prove beneficial for patients with tumors and malignancies. MTT (3-[4,5-dimethylthiazol-2-yl]-2, 5-diphenyltetrazolium bromide) assay results showed that cis-DIDP released from cis-DIDP-loaded solid lipid nanoparticles had better inhibition activity than cis-DIDP that had not been loaded. Keywords: stearic acid, emulsion solvent evaporation method, drug delivery, cis-DIDP, in vitroChen YLi QWu QSDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2014, Iss Issue 1, Pp 3175-3182 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Chen Y Li Q Wu QS Stepwise encapsulation and controlled two-stage release system for cis-Diamminediiodoplatinum
description	Yun Chen,1,* Qian Li,1,2,* Qingsheng Wu1 1Department of Chemistry, Key Laboratory of Yangtze River Water Environment, Ministry of Education, Tongji University, Shanghai; 2Shanghai Institute of Quality Inspection and Technical Research, Shanghai, People’s Republic of China *These authors contributed equally to this work Abstract: cis-Diamminediiodoplatinum (cis-DIDP) is a cisplatin-like anticancer drug with higher anticancer activity, but lower stability and price than cisplatin. In this study, a cis-DIDP carrier system based on micro-sized stearic acid was prepared by an emulsion solvent evaporation method. The maximum drug loading capacity of cis-DIDP-loaded solid lipid nanoparticles was 22.03%, and their encapsulation efficiency was 97.24%. In vitro drug release in phosphate-buffered saline (pH =7.4) at 37.5°C exhibited a unique two-stage process, which could prove beneficial for patients with tumors and malignancies. MTT (3-[4,5-dimethylthiazol-2-yl]-2, 5-diphenyltetrazolium bromide) assay results showed that cis-DIDP released from cis-DIDP-loaded solid lipid nanoparticles had better inhibition activity than cis-DIDP that had not been loaded. Keywords: stearic acid, emulsion solvent evaporation method, drug delivery, cis-DIDP, in vitro
format	article
author	Chen Y Li Q Wu QS
author_facet	Chen Y Li Q Wu QS
author_sort	Chen Y
title	Stepwise encapsulation and controlled two-stage release system for cis-Diamminediiodoplatinum
title_short	Stepwise encapsulation and controlled two-stage release system for cis-Diamminediiodoplatinum
title_full	Stepwise encapsulation and controlled two-stage release system for cis-Diamminediiodoplatinum
title_fullStr	Stepwise encapsulation and controlled two-stage release system for cis-Diamminediiodoplatinum
title_full_unstemmed	Stepwise encapsulation and controlled two-stage release system for cis-Diamminediiodoplatinum
title_sort	stepwise encapsulation and controlled two-stage release system for cis-diamminediiodoplatinum
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/07e055b932104ae2ac395e003fc1ba5e
work_keys_str_mv	AT cheny stepwiseencapsulationandcontrolledtwostagereleasesystemforcisdiamminediiodoplatinum AT liq stepwiseencapsulationandcontrolledtwostagereleasesystemforcisdiamminediiodoplatinum AT wuqs stepwiseencapsulationandcontrolledtwostagereleasesystemforcisdiamminediiodoplatinum
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Stepwise encapsulation and controlled two-stage release system for cis-Diamminediiodoplatinum

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