Subtle alterations in neonatal neurodevelopment following early or late exposure to prenatal maternal immune activation in mice

Prenatal exposure to maternal immune activation (MIA) is a risk factor for a variety of neurodevelopmental and psychiatric disorders. The timing of MIA-exposure has been shown to affect adolescent and adult offspring neurodevelopment, however, less is known about these effects in the neonatal period...

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Autores principales:	Elisa Guma, Emily Snook, Shoshana Spring, Jason P. Lerch, Brian J. Nieman, Gabriel A. Devenyi, M. Mallar Chakravarty
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Maternal immune activation Magnetic resonance imaging Neonate brain development Environmental risk factor Ultrasonic vocalizations Computer applications to medicine. Medical informatics R858-859.7 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/07e124d91a5848289b88f45d5e293cc3
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spelling	oai:doaj.org-article:07e124d91a5848289b88f45d5e293cc32021-11-04T04:30:25ZSubtle alterations in neonatal neurodevelopment following early or late exposure to prenatal maternal immune activation in mice2213-158210.1016/j.nicl.2021.102868https://doaj.org/article/07e124d91a5848289b88f45d5e293cc32021-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2213158221003120https://doaj.org/toc/2213-1582Prenatal exposure to maternal immune activation (MIA) is a risk factor for a variety of neurodevelopmental and psychiatric disorders. The timing of MIA-exposure has been shown to affect adolescent and adult offspring neurodevelopment, however, less is known about these effects in the neonatal period. To better understand the impact of MIA-exposure on neonatal brain development in a mouse model, we assess neonate communicative abilities with the ultrasonic vocalization task, followed by high-resolution ex vivo magnetic resonance imaging (MRI) on the neonatal (postnatal day 8) mouse brain. Early exposed offspring displayed decreased communicative ability, while brain anatomy appeared largely unaffected, apart from some subtle alterations. By integrating MRI and behavioural assays to investigate the effects of MIA-exposure on neonatal neurodevelopment we show that offspring neuroanatomy and behaviour are only subtly affected by both early and late exposure. This suggests that the deficits often observed in later stages of life may be dormant, not yet developed in the neonatal period, or not as easily detectable using a cross-sectional approach.Elisa GumaEmily SnookShoshana SpringJason P. LerchBrian J. NiemanGabriel A. DevenyiM. Mallar ChakravartyElsevierarticleMaternal immune activationMagnetic resonance imagingNeonate brain developmentEnvironmental risk factorUltrasonic vocalizationsComputer applications to medicine. Medical informaticsR858-859.7Neurology. Diseases of the nervous systemRC346-429ENNeuroImage: Clinical, Vol 32, Iss , Pp 102868- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Maternal immune activation Magnetic resonance imaging Neonate brain development Environmental risk factor Ultrasonic vocalizations Computer applications to medicine. Medical informatics R858-859.7 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Maternal immune activation Magnetic resonance imaging Neonate brain development Environmental risk factor Ultrasonic vocalizations Computer applications to medicine. Medical informatics R858-859.7 Neurology. Diseases of the nervous system RC346-429 Elisa Guma Emily Snook Shoshana Spring Jason P. Lerch Brian J. Nieman Gabriel A. Devenyi M. Mallar Chakravarty Subtle alterations in neonatal neurodevelopment following early or late exposure to prenatal maternal immune activation in mice
description	Prenatal exposure to maternal immune activation (MIA) is a risk factor for a variety of neurodevelopmental and psychiatric disorders. The timing of MIA-exposure has been shown to affect adolescent and adult offspring neurodevelopment, however, less is known about these effects in the neonatal period. To better understand the impact of MIA-exposure on neonatal brain development in a mouse model, we assess neonate communicative abilities with the ultrasonic vocalization task, followed by high-resolution ex vivo magnetic resonance imaging (MRI) on the neonatal (postnatal day 8) mouse brain. Early exposed offspring displayed decreased communicative ability, while brain anatomy appeared largely unaffected, apart from some subtle alterations. By integrating MRI and behavioural assays to investigate the effects of MIA-exposure on neonatal neurodevelopment we show that offspring neuroanatomy and behaviour are only subtly affected by both early and late exposure. This suggests that the deficits often observed in later stages of life may be dormant, not yet developed in the neonatal period, or not as easily detectable using a cross-sectional approach.
format	article
author	Elisa Guma Emily Snook Shoshana Spring Jason P. Lerch Brian J. Nieman Gabriel A. Devenyi M. Mallar Chakravarty
author_facet	Elisa Guma Emily Snook Shoshana Spring Jason P. Lerch Brian J. Nieman Gabriel A. Devenyi M. Mallar Chakravarty
author_sort	Elisa Guma
title	Subtle alterations in neonatal neurodevelopment following early or late exposure to prenatal maternal immune activation in mice
title_short	Subtle alterations in neonatal neurodevelopment following early or late exposure to prenatal maternal immune activation in mice
title_full	Subtle alterations in neonatal neurodevelopment following early or late exposure to prenatal maternal immune activation in mice
title_fullStr	Subtle alterations in neonatal neurodevelopment following early or late exposure to prenatal maternal immune activation in mice
title_full_unstemmed	Subtle alterations in neonatal neurodevelopment following early or late exposure to prenatal maternal immune activation in mice
title_sort	subtle alterations in neonatal neurodevelopment following early or late exposure to prenatal maternal immune activation in mice
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/07e124d91a5848289b88f45d5e293cc3
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Subtle alterations in neonatal neurodevelopment following early or late exposure to prenatal maternal immune activation in mice

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