Genetic Characterization of Novel H7Nx Low Pathogenic Avian Influenza Viruses from Wild Birds in South Korea during the Winter of 2020–2021

Zoonotic infection with avian influenza viruses (AIVs) of subtype H7, such as H7N9 and H7N4, has raised concerns worldwide. During the winter of 2020–2021, five novel H7 low pathogenic AIVs (LPAIVs) containing different neuraminidase (NA) subtypes, including two H7N3, an H7N8, and two H7N9, were det...

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Autores principales:	Yu-Na Lee, Dong-Hun Lee, Jung-Hoon Kwon, Jae-In Shin, Seo Yun Hong, Ra Mi Cha, Yoon-Gi Baek, Eun-Kyoung Lee, Mingeun Sagong, Gyeong-Beum Heo, Kwang-Nyeong Lee, Youn-Jeong Lee
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	avian influenza virus H7 reassortant phylogenetic analysis wild bird Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/07e6c43d005f4747bee160c073ee3682
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spelling	oai:doaj.org-article:07e6c43d005f4747bee160c073ee36822021-11-25T19:14:00ZGenetic Characterization of Novel H7Nx Low Pathogenic Avian Influenza Viruses from Wild Birds in South Korea during the Winter of 2020–202110.3390/v131122741999-4915https://doaj.org/article/07e6c43d005f4747bee160c073ee36822021-11-01T00:00:00Zhttps://www.mdpi.com/1999-4915/13/11/2274https://doaj.org/toc/1999-4915Zoonotic infection with avian influenza viruses (AIVs) of subtype H7, such as H7N9 and H7N4, has raised concerns worldwide. During the winter of 2020–2021, five novel H7 low pathogenic AIVs (LPAIVs) containing different neuraminidase (NA) subtypes, including two H7N3, an H7N8, and two H7N9, were detected in wild bird feces in South Korea. Complete genome sequencing and phylogenetic analysis showed that the novel H7Nx AIVs were reassortants containing two gene segments (hemagglutinin (HA) and matrix) that were related to the zoonotic Jiangsu–Cambodian H7 viruses causing zoonotic infection and six gene segments originating from LPAIVs circulating in migratory birds in Eurasia. A genomic constellation analysis demonstrated that all H7 isolates contained a mix of gene segments from different viruses, indicating that multiple reassortment occurred. The well-known mammalian adaptive substitution (E627K and D701N) in PB2 was not detected in any of these isolates. The detection of multiple reassortant H7Nx AIVs in wild birds highlights the need for intensive surveillance in both wild birds and poultry in Eurasia.Yu-Na LeeDong-Hun LeeJung-Hoon KwonJae-In ShinSeo Yun HongRa Mi ChaYoon-Gi BaekEun-Kyoung LeeMingeun SagongGyeong-Beum HeoKwang-Nyeong LeeYoun-Jeong LeeMDPI AGarticleavian influenza virusH7reassortantphylogenetic analysiswild birdMicrobiologyQR1-502ENViruses, Vol 13, Iss 2274, p 2274 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	avian influenza virus H7 reassortant phylogenetic analysis wild bird Microbiology QR1-502
spellingShingle	avian influenza virus H7 reassortant phylogenetic analysis wild bird Microbiology QR1-502 Yu-Na Lee Dong-Hun Lee Jung-Hoon Kwon Jae-In Shin Seo Yun Hong Ra Mi Cha Yoon-Gi Baek Eun-Kyoung Lee Mingeun Sagong Gyeong-Beum Heo Kwang-Nyeong Lee Youn-Jeong Lee Genetic Characterization of Novel H7Nx Low Pathogenic Avian Influenza Viruses from Wild Birds in South Korea during the Winter of 2020–2021
description	Zoonotic infection with avian influenza viruses (AIVs) of subtype H7, such as H7N9 and H7N4, has raised concerns worldwide. During the winter of 2020–2021, five novel H7 low pathogenic AIVs (LPAIVs) containing different neuraminidase (NA) subtypes, including two H7N3, an H7N8, and two H7N9, were detected in wild bird feces in South Korea. Complete genome sequencing and phylogenetic analysis showed that the novel H7Nx AIVs were reassortants containing two gene segments (hemagglutinin (HA) and matrix) that were related to the zoonotic Jiangsu–Cambodian H7 viruses causing zoonotic infection and six gene segments originating from LPAIVs circulating in migratory birds in Eurasia. A genomic constellation analysis demonstrated that all H7 isolates contained a mix of gene segments from different viruses, indicating that multiple reassortment occurred. The well-known mammalian adaptive substitution (E627K and D701N) in PB2 was not detected in any of these isolates. The detection of multiple reassortant H7Nx AIVs in wild birds highlights the need for intensive surveillance in both wild birds and poultry in Eurasia.
format	article
author	Yu-Na Lee Dong-Hun Lee Jung-Hoon Kwon Jae-In Shin Seo Yun Hong Ra Mi Cha Yoon-Gi Baek Eun-Kyoung Lee Mingeun Sagong Gyeong-Beum Heo Kwang-Nyeong Lee Youn-Jeong Lee
author_facet	Yu-Na Lee Dong-Hun Lee Jung-Hoon Kwon Jae-In Shin Seo Yun Hong Ra Mi Cha Yoon-Gi Baek Eun-Kyoung Lee Mingeun Sagong Gyeong-Beum Heo Kwang-Nyeong Lee Youn-Jeong Lee
author_sort	Yu-Na Lee
title	Genetic Characterization of Novel H7Nx Low Pathogenic Avian Influenza Viruses from Wild Birds in South Korea during the Winter of 2020–2021
title_short	Genetic Characterization of Novel H7Nx Low Pathogenic Avian Influenza Viruses from Wild Birds in South Korea during the Winter of 2020–2021
title_full	Genetic Characterization of Novel H7Nx Low Pathogenic Avian Influenza Viruses from Wild Birds in South Korea during the Winter of 2020–2021
title_fullStr	Genetic Characterization of Novel H7Nx Low Pathogenic Avian Influenza Viruses from Wild Birds in South Korea during the Winter of 2020–2021
title_full_unstemmed	Genetic Characterization of Novel H7Nx Low Pathogenic Avian Influenza Viruses from Wild Birds in South Korea during the Winter of 2020–2021
title_sort	genetic characterization of novel h7nx low pathogenic avian influenza viruses from wild birds in south korea during the winter of 2020–2021
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/07e6c43d005f4747bee160c073ee3682
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Genetic Characterization of Novel H7Nx Low Pathogenic Avian Influenza Viruses from Wild Birds in South Korea during the Winter of 2020–2021

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