Long non-coding RNA NR2F1-AS1 induces breast cancer lung metastatic dormancy by regulating NR2F1 and ΔNp63

Disseminated tumor cells often become dormant before awakening for metastatic growth. Here, the authors report that the lncRNA, NR2F1-AS1, is upregulated in dormant mesenchymal-like breast cancer stem-like cells and promotes dissemination but inhibits proliferation, leading to metastatic dormancy.

Guardado en:

Detalles Bibliográficos
Autores principales:	Yingjie Liu, Peiyuan Zhang, Qiuyao Wu, Houqin Fang, Yuan Wang, Yansen Xiao, Min Cong, Tingting Wang, Yunfei He, Chengxin Ma, Pu Tian, Yajun Liang, Lun-Xiu Qin, Qingcheng Yang, Qifeng Yang, Lujian Liao, Guohong Hu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/07e81bee36584122863394784ddcccb2
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:07e81bee36584122863394784ddcccb2
record_format	dspace
spelling	oai:doaj.org-article:07e81bee36584122863394784ddcccb22021-12-02T15:25:36ZLong non-coding RNA NR2F1-AS1 induces breast cancer lung metastatic dormancy by regulating NR2F1 and ΔNp6310.1038/s41467-021-25552-02041-1723https://doaj.org/article/07e81bee36584122863394784ddcccb22021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25552-0https://doaj.org/toc/2041-1723Disseminated tumor cells often become dormant before awakening for metastatic growth. Here, the authors report that the lncRNA, NR2F1-AS1, is upregulated in dormant mesenchymal-like breast cancer stem-like cells and promotes dissemination but inhibits proliferation, leading to metastatic dormancy.Yingjie LiuPeiyuan ZhangQiuyao WuHouqin FangYuan WangYansen XiaoMin CongTingting WangYunfei HeChengxin MaPu TianYajun LiangLun-Xiu QinQingcheng YangQifeng YangLujian LiaoGuohong HuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yingjie Liu Peiyuan Zhang Qiuyao Wu Houqin Fang Yuan Wang Yansen Xiao Min Cong Tingting Wang Yunfei He Chengxin Ma Pu Tian Yajun Liang Lun-Xiu Qin Qingcheng Yang Qifeng Yang Lujian Liao Guohong Hu Long non-coding RNA NR2F1-AS1 induces breast cancer lung metastatic dormancy by regulating NR2F1 and ΔNp63
description	Disseminated tumor cells often become dormant before awakening for metastatic growth. Here, the authors report that the lncRNA, NR2F1-AS1, is upregulated in dormant mesenchymal-like breast cancer stem-like cells and promotes dissemination but inhibits proliferation, leading to metastatic dormancy.
format	article
author	Yingjie Liu Peiyuan Zhang Qiuyao Wu Houqin Fang Yuan Wang Yansen Xiao Min Cong Tingting Wang Yunfei He Chengxin Ma Pu Tian Yajun Liang Lun-Xiu Qin Qingcheng Yang Qifeng Yang Lujian Liao Guohong Hu
author_facet	Yingjie Liu Peiyuan Zhang Qiuyao Wu Houqin Fang Yuan Wang Yansen Xiao Min Cong Tingting Wang Yunfei He Chengxin Ma Pu Tian Yajun Liang Lun-Xiu Qin Qingcheng Yang Qifeng Yang Lujian Liao Guohong Hu
author_sort	Yingjie Liu
title	Long non-coding RNA NR2F1-AS1 induces breast cancer lung metastatic dormancy by regulating NR2F1 and ΔNp63
title_short	Long non-coding RNA NR2F1-AS1 induces breast cancer lung metastatic dormancy by regulating NR2F1 and ΔNp63
title_full	Long non-coding RNA NR2F1-AS1 induces breast cancer lung metastatic dormancy by regulating NR2F1 and ΔNp63
title_fullStr	Long non-coding RNA NR2F1-AS1 induces breast cancer lung metastatic dormancy by regulating NR2F1 and ΔNp63
title_full_unstemmed	Long non-coding RNA NR2F1-AS1 induces breast cancer lung metastatic dormancy by regulating NR2F1 and ΔNp63
title_sort	long non-coding rna nr2f1-as1 induces breast cancer lung metastatic dormancy by regulating nr2f1 and δnp63
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/07e81bee36584122863394784ddcccb2
work_keys_str_mv	AT yingjieliu longnoncodingrnanr2f1as1inducesbreastcancerlungmetastaticdormancybyregulatingnr2f1anddnp63 AT peiyuanzhang longnoncodingrnanr2f1as1inducesbreastcancerlungmetastaticdormancybyregulatingnr2f1anddnp63 AT qiuyaowu longnoncodingrnanr2f1as1inducesbreastcancerlungmetastaticdormancybyregulatingnr2f1anddnp63 AT houqinfang longnoncodingrnanr2f1as1inducesbreastcancerlungmetastaticdormancybyregulatingnr2f1anddnp63 AT yuanwang longnoncodingrnanr2f1as1inducesbreastcancerlungmetastaticdormancybyregulatingnr2f1anddnp63 AT yansenxiao longnoncodingrnanr2f1as1inducesbreastcancerlungmetastaticdormancybyregulatingnr2f1anddnp63 AT mincong longnoncodingrnanr2f1as1inducesbreastcancerlungmetastaticdormancybyregulatingnr2f1anddnp63 AT tingtingwang longnoncodingrnanr2f1as1inducesbreastcancerlungmetastaticdormancybyregulatingnr2f1anddnp63 AT yunfeihe longnoncodingrnanr2f1as1inducesbreastcancerlungmetastaticdormancybyregulatingnr2f1anddnp63 AT chengxinma longnoncodingrnanr2f1as1inducesbreastcancerlungmetastaticdormancybyregulatingnr2f1anddnp63 AT putian longnoncodingrnanr2f1as1inducesbreastcancerlungmetastaticdormancybyregulatingnr2f1anddnp63 AT yajunliang longnoncodingrnanr2f1as1inducesbreastcancerlungmetastaticdormancybyregulatingnr2f1anddnp63 AT lunxiuqin longnoncodingrnanr2f1as1inducesbreastcancerlungmetastaticdormancybyregulatingnr2f1anddnp63 AT qingchengyang longnoncodingrnanr2f1as1inducesbreastcancerlungmetastaticdormancybyregulatingnr2f1anddnp63 AT qifengyang longnoncodingrnanr2f1as1inducesbreastcancerlungmetastaticdormancybyregulatingnr2f1anddnp63 AT lujianliao longnoncodingrnanr2f1as1inducesbreastcancerlungmetastaticdormancybyregulatingnr2f1anddnp63 AT guohonghu longnoncodingrnanr2f1as1inducesbreastcancerlungmetastaticdormancybyregulatingnr2f1anddnp63
_version_	1718387244287393792

Long non-coding RNA NR2F1-AS1 induces breast cancer lung metastatic dormancy by regulating NR2F1 and ΔNp63

Ejemplares similares