Considering the Cellular Composition of Olfactory Ensheathing Cell Transplants for Spinal Cord Injury Repair: A Review of the Literature

Olfactory ensheathing cells (OECs) are specialized glia cells of the olfactory system that support the continual regeneration of olfactory neurons throughout adulthood. Owing to their pro-regenerative properties, OECs have been transplanted in animal models of spinal cord injuries (SCI) and trialed...

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Autores principales:	Mahjabeen Miah, Patrizia Ferretti, David Choi
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	cell transplantation glial cells olfactory ensheathing cells cellular composition neuroregeneration spinal cord injury Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/07ea9fcc0c3d4cf3a226371a5fd6603d
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spelling	oai:doaj.org-article:07ea9fcc0c3d4cf3a226371a5fd6603d2021-11-17T06:33:24ZConsidering the Cellular Composition of Olfactory Ensheathing Cell Transplants for Spinal Cord Injury Repair: A Review of the Literature1662-510210.3389/fncel.2021.781489https://doaj.org/article/07ea9fcc0c3d4cf3a226371a5fd6603d2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fncel.2021.781489/fullhttps://doaj.org/toc/1662-5102Olfactory ensheathing cells (OECs) are specialized glia cells of the olfactory system that support the continual regeneration of olfactory neurons throughout adulthood. Owing to their pro-regenerative properties, OECs have been transplanted in animal models of spinal cord injuries (SCI) and trialed in clinical studies on SCI patients. Although these studies have provided convincing evidence to support the continued development of OEC transplantation as a treatment option for the repair of SCI, discrepancies in the reported outcome has shown that OEC transplantation requires further improvement. Much of the variability in the reparative potential of OEC transplants is due to the variations in the cell composition of transplants between studies. As a result, the optimal cell preparation is currently a subject of debate. Here we review, the characterization as well as the effect of the cell composition of olfactory cell transplantation on therapeutic outcome in SCI. Firstly, we summarize and review the cell composition of olfactory cell preparations across the different species studied prior to transplantation. Since the purity of cells in olfactory transplants might affect the study outcome we also examine the effect of the proportions of OECs and the different cell types identified in the transplant on neuroregeneration. Finally, we consider the effect of the yield of cells on neuroregeneration by assessing the cell dose of transplants on therapeutic outcome.Mahjabeen MiahPatrizia FerrettiDavid ChoiFrontiers Media S.A.articlecell transplantationglial cellsolfactory ensheathing cellscellular compositionneuroregenerationspinal cord injuryNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Cellular Neuroscience, Vol 15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cell transplantation glial cells olfactory ensheathing cells cellular composition neuroregeneration spinal cord injury Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	cell transplantation glial cells olfactory ensheathing cells cellular composition neuroregeneration spinal cord injury Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Mahjabeen Miah Patrizia Ferretti David Choi Considering the Cellular Composition of Olfactory Ensheathing Cell Transplants for Spinal Cord Injury Repair: A Review of the Literature
description	Olfactory ensheathing cells (OECs) are specialized glia cells of the olfactory system that support the continual regeneration of olfactory neurons throughout adulthood. Owing to their pro-regenerative properties, OECs have been transplanted in animal models of spinal cord injuries (SCI) and trialed in clinical studies on SCI patients. Although these studies have provided convincing evidence to support the continued development of OEC transplantation as a treatment option for the repair of SCI, discrepancies in the reported outcome has shown that OEC transplantation requires further improvement. Much of the variability in the reparative potential of OEC transplants is due to the variations in the cell composition of transplants between studies. As a result, the optimal cell preparation is currently a subject of debate. Here we review, the characterization as well as the effect of the cell composition of olfactory cell transplantation on therapeutic outcome in SCI. Firstly, we summarize and review the cell composition of olfactory cell preparations across the different species studied prior to transplantation. Since the purity of cells in olfactory transplants might affect the study outcome we also examine the effect of the proportions of OECs and the different cell types identified in the transplant on neuroregeneration. Finally, we consider the effect of the yield of cells on neuroregeneration by assessing the cell dose of transplants on therapeutic outcome.
format	article
author	Mahjabeen Miah Patrizia Ferretti David Choi
author_facet	Mahjabeen Miah Patrizia Ferretti David Choi
author_sort	Mahjabeen Miah
title	Considering the Cellular Composition of Olfactory Ensheathing Cell Transplants for Spinal Cord Injury Repair: A Review of the Literature
title_short	Considering the Cellular Composition of Olfactory Ensheathing Cell Transplants for Spinal Cord Injury Repair: A Review of the Literature
title_full	Considering the Cellular Composition of Olfactory Ensheathing Cell Transplants for Spinal Cord Injury Repair: A Review of the Literature
title_fullStr	Considering the Cellular Composition of Olfactory Ensheathing Cell Transplants for Spinal Cord Injury Repair: A Review of the Literature
title_full_unstemmed	Considering the Cellular Composition of Olfactory Ensheathing Cell Transplants for Spinal Cord Injury Repair: A Review of the Literature
title_sort	considering the cellular composition of olfactory ensheathing cell transplants for spinal cord injury repair: a review of the literature
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/07ea9fcc0c3d4cf3a226371a5fd6603d
work_keys_str_mv	AT mahjabeenmiah consideringthecellularcompositionofolfactoryensheathingcelltransplantsforspinalcordinjuryrepairareviewoftheliterature AT patriziaferretti consideringthecellularcompositionofolfactoryensheathingcelltransplantsforspinalcordinjuryrepairareviewoftheliterature AT davidchoi consideringthecellularcompositionofolfactoryensheathingcelltransplantsforspinalcordinjuryrepairareviewoftheliterature
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Considering the Cellular Composition of Olfactory Ensheathing Cell Transplants for Spinal Cord Injury Repair: A Review of the Literature

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