An Integrative Pan-Cancer Analysis of PBK in Human Tumors

Background: PDZ binding kinase (PBK) is a serine/threonine kinase, which belongs to the mitogen-activated protein kinase kinase (MAPKK) family. It has been shown to be a critical gene in the regulation of mitosis and tumorigenesis, but the role of PBK in various cancers remains unclear. In this stud...

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Autores principales:	Huantao Wen, Zitao Chen, Min Li, Qiongzhen Huang, Yuhao Deng, Jiawei Zheng, Moliang Xiong, Pengfei Wang, Wangming Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	pan-cancer PBK biomarker tumor cell proliferation prognosis Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/07eb1fecbc8f4a0f928234d9b270337a
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spelling	oai:doaj.org-article:07eb1fecbc8f4a0f928234d9b270337a2021-11-10T07:31:41ZAn Integrative Pan-Cancer Analysis of PBK in Human Tumors2296-889X10.3389/fmolb.2021.755911https://doaj.org/article/07eb1fecbc8f4a0f928234d9b270337a2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmolb.2021.755911/fullhttps://doaj.org/toc/2296-889XBackground: PDZ binding kinase (PBK) is a serine/threonine kinase, which belongs to the mitogen-activated protein kinase kinase (MAPKK) family. It has been shown to be a critical gene in the regulation of mitosis and tumorigenesis, but the role of PBK in various cancers remains unclear. In this study, we systematically explored the prognostic and predictive value of PBK expression in 33 cancer types.Methods: Public databases including the cBioPortal database, GDSC database, GTEx database, CCLE database, and TCGA database were used to detect the PBK expression and its association with the prognosis, clinicopathologic stage, TMB, MSI, immune microenvironment, immune checkpoints, immune cell infiltration, enrichment pathways, and IC50 across pan-cancer. The statistical analyses and visualization were conducted using R software.Results: PBK expression is relatively high in most cancers compared to their normal counterparts, and this gene is barely expressed in normal tissues. High expression of PBK is significantly associated with poor prognosis and clinicopathologic stages I, II, and III in different cancers. Furthermore, PBK expression is strongly associated with TMB in 23 cancer types and associated with MSI in nine cancer types. Moreover, the correlation analysis of the microenvironment and immune cells indicated that PBK is negatively correlated with the immune infiltration levels but positively correlated with the infiltration levels of M0 and M1 macrophages, T cells CD4 memory activated, and T cells follicular helper. GSEA analysis revealed that the biological function or pathways relevant to the cell cycle and mitosis were frequently enriched at the level of high expression of PBK.Conclusion: These results revealed the oncogenic role of PBK, which is significantly upregulated in various cancers and indicated poor prognosis and immune infiltration in multiple cancers. It also suggested that PBK may serve as a biomarker in multiple tumor progress and patient survival.Huantao WenZitao ChenMin LiQiongzhen HuangYuhao DengJiawei ZhengMoliang XiongPengfei WangWangming ZhangFrontiers Media S.A.articlepan-cancerPBKbiomarkertumor cell proliferationprognosisBiology (General)QH301-705.5ENFrontiers in Molecular Biosciences, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	pan-cancer PBK biomarker tumor cell proliferation prognosis Biology (General) QH301-705.5
spellingShingle	pan-cancer PBK biomarker tumor cell proliferation prognosis Biology (General) QH301-705.5 Huantao Wen Zitao Chen Min Li Qiongzhen Huang Yuhao Deng Jiawei Zheng Moliang Xiong Pengfei Wang Wangming Zhang An Integrative Pan-Cancer Analysis of PBK in Human Tumors
description	Background: PDZ binding kinase (PBK) is a serine/threonine kinase, which belongs to the mitogen-activated protein kinase kinase (MAPKK) family. It has been shown to be a critical gene in the regulation of mitosis and tumorigenesis, but the role of PBK in various cancers remains unclear. In this study, we systematically explored the prognostic and predictive value of PBK expression in 33 cancer types.Methods: Public databases including the cBioPortal database, GDSC database, GTEx database, CCLE database, and TCGA database were used to detect the PBK expression and its association with the prognosis, clinicopathologic stage, TMB, MSI, immune microenvironment, immune checkpoints, immune cell infiltration, enrichment pathways, and IC50 across pan-cancer. The statistical analyses and visualization were conducted using R software.Results: PBK expression is relatively high in most cancers compared to their normal counterparts, and this gene is barely expressed in normal tissues. High expression of PBK is significantly associated with poor prognosis and clinicopathologic stages I, II, and III in different cancers. Furthermore, PBK expression is strongly associated with TMB in 23 cancer types and associated with MSI in nine cancer types. Moreover, the correlation analysis of the microenvironment and immune cells indicated that PBK is negatively correlated with the immune infiltration levels but positively correlated with the infiltration levels of M0 and M1 macrophages, T cells CD4 memory activated, and T cells follicular helper. GSEA analysis revealed that the biological function or pathways relevant to the cell cycle and mitosis were frequently enriched at the level of high expression of PBK.Conclusion: These results revealed the oncogenic role of PBK, which is significantly upregulated in various cancers and indicated poor prognosis and immune infiltration in multiple cancers. It also suggested that PBK may serve as a biomarker in multiple tumor progress and patient survival.
format	article
author	Huantao Wen Zitao Chen Min Li Qiongzhen Huang Yuhao Deng Jiawei Zheng Moliang Xiong Pengfei Wang Wangming Zhang
author_facet	Huantao Wen Zitao Chen Min Li Qiongzhen Huang Yuhao Deng Jiawei Zheng Moliang Xiong Pengfei Wang Wangming Zhang
author_sort	Huantao Wen
title	An Integrative Pan-Cancer Analysis of PBK in Human Tumors
title_short	An Integrative Pan-Cancer Analysis of PBK in Human Tumors
title_full	An Integrative Pan-Cancer Analysis of PBK in Human Tumors
title_fullStr	An Integrative Pan-Cancer Analysis of PBK in Human Tumors
title_full_unstemmed	An Integrative Pan-Cancer Analysis of PBK in Human Tumors
title_sort	integrative pan-cancer analysis of pbk in human tumors
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/07eb1fecbc8f4a0f928234d9b270337a
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An Integrative Pan-Cancer Analysis of PBK in Human Tumors

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