Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA

Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA

The RNA-binding proteins Roquin-1 and Roquin-2 are essential for immune cell function and postnatal survival in mice. Here, the authors identify NUFIP2 as a cofactor of Roquin; Roquin binds and stabilizes NUFIP2 in cells while NUFIP2 regulates Roquin mRNA target recognition.

Guardado en:
Detalles Bibliográficos
Autores principales: Nina Rehage, Elena Davydova, Christine Conrad, Gesine Behrens, Andreas Maiser, Jenny E. Stehklein, Sven Brenner, Juliane Klein, Aicha Jeridi, Anne Hoffmann, Eunhae Lee, Umberto Dianzani, Rob Willemsen, Regina Feederle, Kristin Reiche, Jörg Hackermüller, Heinrich Leonhardt, Sonia Sharma, Dierk Niessing, Vigo Heissmeyer
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/07ebcb03963546dcad91d3831f14ddd0
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:07ebcb03963546dcad91d3831f14ddd0
record_format dspace
spelling oai:doaj.org-article:07ebcb03963546dcad91d3831f14ddd02021-12-02T16:49:35ZBinding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA10.1038/s41467-017-02582-12041-1723https://doaj.org/article/07ebcb03963546dcad91d3831f14ddd02018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02582-1https://doaj.org/toc/2041-1723The RNA-binding proteins Roquin-1 and Roquin-2 are essential for immune cell function and postnatal survival in mice. Here, the authors identify NUFIP2 as a cofactor of Roquin; Roquin binds and stabilizes NUFIP2 in cells while NUFIP2 regulates Roquin mRNA target recognition.Nina RehageElena DavydovaChristine ConradGesine BehrensAndreas MaiserJenny E. StehkleinSven BrennerJuliane KleinAicha JeridiAnne HoffmannEunhae LeeUmberto DianzaniRob WillemsenRegina FeederleKristin ReicheJörg HackermüllerHeinrich LeonhardtSonia SharmaDierk NiessingVigo HeissmeyerNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Nina Rehage
Elena Davydova
Christine Conrad
Gesine Behrens
Andreas Maiser
Jenny E. Stehklein
Sven Brenner
Juliane Klein
Aicha Jeridi
Anne Hoffmann
Eunhae Lee
Umberto Dianzani
Rob Willemsen
Regina Feederle
Kristin Reiche
Jörg Hackermüller
Heinrich Leonhardt
Sonia Sharma
Dierk Niessing
Vigo Heissmeyer
Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA
description The RNA-binding proteins Roquin-1 and Roquin-2 are essential for immune cell function and postnatal survival in mice. Here, the authors identify NUFIP2 as a cofactor of Roquin; Roquin binds and stabilizes NUFIP2 in cells while NUFIP2 regulates Roquin mRNA target recognition.
format article
author Nina Rehage
Elena Davydova
Christine Conrad
Gesine Behrens
Andreas Maiser
Jenny E. Stehklein
Sven Brenner
Juliane Klein
Aicha Jeridi
Anne Hoffmann
Eunhae Lee
Umberto Dianzani
Rob Willemsen
Regina Feederle
Kristin Reiche
Jörg Hackermüller
Heinrich Leonhardt
Sonia Sharma
Dierk Niessing
Vigo Heissmeyer
author_facet Nina Rehage
Elena Davydova
Christine Conrad
Gesine Behrens
Andreas Maiser
Jenny E. Stehklein
Sven Brenner
Juliane Klein
Aicha Jeridi
Anne Hoffmann
Eunhae Lee
Umberto Dianzani
Rob Willemsen
Regina Feederle
Kristin Reiche
Jörg Hackermüller
Heinrich Leonhardt
Sonia Sharma
Dierk Niessing
Vigo Heissmeyer
author_sort Nina Rehage
title Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA
title_short Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA
title_full Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA
title_fullStr Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA
title_full_unstemmed Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA
title_sort binding of nufip2 to roquin promotes recognition and regulation of icos mrna
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/07ebcb03963546dcad91d3831f14ddd0
work_keys_str_mv AT ninarehage bindingofnufip2toroquinpromotesrecognitionandregulationoficosmrna
AT elenadavydova bindingofnufip2toroquinpromotesrecognitionandregulationoficosmrna
AT christineconrad bindingofnufip2toroquinpromotesrecognitionandregulationoficosmrna
AT gesinebehrens bindingofnufip2toroquinpromotesrecognitionandregulationoficosmrna
AT andreasmaiser bindingofnufip2toroquinpromotesrecognitionandregulationoficosmrna
AT jennyestehklein bindingofnufip2toroquinpromotesrecognitionandregulationoficosmrna
AT svenbrenner bindingofnufip2toroquinpromotesrecognitionandregulationoficosmrna
AT julianeklein bindingofnufip2toroquinpromotesrecognitionandregulationoficosmrna
AT aichajeridi bindingofnufip2toroquinpromotesrecognitionandregulationoficosmrna
AT annehoffmann bindingofnufip2toroquinpromotesrecognitionandregulationoficosmrna
AT eunhaelee bindingofnufip2toroquinpromotesrecognitionandregulationoficosmrna
AT umbertodianzani bindingofnufip2toroquinpromotesrecognitionandregulationoficosmrna
AT robwillemsen bindingofnufip2toroquinpromotesrecognitionandregulationoficosmrna
AT reginafeederle bindingofnufip2toroquinpromotesrecognitionandregulationoficosmrna
AT kristinreiche bindingofnufip2toroquinpromotesrecognitionandregulationoficosmrna
AT jorghackermuller bindingofnufip2toroquinpromotesrecognitionandregulationoficosmrna
AT heinrichleonhardt bindingofnufip2toroquinpromotesrecognitionandregulationoficosmrna
AT soniasharma bindingofnufip2toroquinpromotesrecognitionandregulationoficosmrna
AT dierkniessing bindingofnufip2toroquinpromotesrecognitionandregulationoficosmrna
AT vigoheissmeyer bindingofnufip2toroquinpromotesrecognitionandregulationoficosmrna
_version_ 1718383257985220608

Ejemplares similares