Appraising clinical applicability of studies: mapping and synthesis of current frameworks, and proposal of the FrACAS framework and VICORT checklist

Abstract Background Not all research findings are translated to clinical practice. Reasons for lack of applicability are varied, and multiple frameworks and criteria exist to appraise the general applicability of epidemiological and clinical research. In this two-part study, we identify, map, and sy...

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Autores principales:	Quoc Dinh Nguyen, Erica M. Moodie, Philippe Desmarais, Robert Goulden, Marie-France Forget, Eric Peters, Sahar Saeed, Mark R. Keezer, Christina Wolfson
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Quality assessment External validity Generalizability Impact Evidence-based practice Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/07ed91c2d3984d3f9a5f2128199c2b31
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spelling	oai:doaj.org-article:07ed91c2d3984d3f9a5f2128199c2b312021-11-14T12:39:37ZAppraising clinical applicability of studies: mapping and synthesis of current frameworks, and proposal of the FrACAS framework and VICORT checklist10.1186/s12874-021-01445-01471-2288https://doaj.org/article/07ed91c2d3984d3f9a5f2128199c2b312021-11-01T00:00:00Zhttps://doi.org/10.1186/s12874-021-01445-0https://doaj.org/toc/1471-2288Abstract Background Not all research findings are translated to clinical practice. Reasons for lack of applicability are varied, and multiple frameworks and criteria exist to appraise the general applicability of epidemiological and clinical research. In this two-part study, we identify, map, and synthesize frameworks and criteria; we develop a framework to assist clinicians to appraise applicability specifically from a clinical perspective. Methods We conducted a literature search in PubMed and Embase to identify frameworks appraising applicability of study results. Conceptual thematic analysis was used to synthesize frameworks and criteria. We carried out a framework development process integrating contemporary debates in epidemiology, findings from the literature search and synthesis, iterative pilot-testing, and brainstorming and consensus discussions to propose a concise framework to appraise clinical applicability. Results Of the 4622 references retrieved, we identified 26 unique frameworks featuring 21 criteria. Frameworks and criteria varied by scope and level of aggregation of the evidence appraised, target user, and specific area of applicability (internal validity, clinical applicability, external validity, and system applicability). Our proposed Framework Appraising the Clinical Applicability of Studies (FrACAS) classifies studies in three domains (research, practice informing, and practice changing) by examining six criteria sequentially: Validity, Indication-informativeness, Clinical relevance, Originality, Risk-benefit comprehensiveness, and Transposability (VICORT checklist). Conclusions Existing frameworks to applicability vary by scope, target user, and area of applicability. We introduce FrACAS to specifically assess applicability from a clinical perspective. Our framework can be used as a tool for the design, appraisal, and interpretation of epidemiological and clinical studies.Quoc Dinh NguyenErica M. MoodiePhilippe DesmaraisRobert GouldenMarie-France ForgetEric PetersSahar SaeedMark R. KeezerChristina WolfsonBMCarticleQuality assessmentExternal validityGeneralizabilityImpactEvidence-based practiceMedicine (General)R5-920ENBMC Medical Research Methodology, Vol 21, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Quality assessment External validity Generalizability Impact Evidence-based practice Medicine (General) R5-920
spellingShingle	Quality assessment External validity Generalizability Impact Evidence-based practice Medicine (General) R5-920 Quoc Dinh Nguyen Erica M. Moodie Philippe Desmarais Robert Goulden Marie-France Forget Eric Peters Sahar Saeed Mark R. Keezer Christina Wolfson Appraising clinical applicability of studies: mapping and synthesis of current frameworks, and proposal of the FrACAS framework and VICORT checklist
description	Abstract Background Not all research findings are translated to clinical practice. Reasons for lack of applicability are varied, and multiple frameworks and criteria exist to appraise the general applicability of epidemiological and clinical research. In this two-part study, we identify, map, and synthesize frameworks and criteria; we develop a framework to assist clinicians to appraise applicability specifically from a clinical perspective. Methods We conducted a literature search in PubMed and Embase to identify frameworks appraising applicability of study results. Conceptual thematic analysis was used to synthesize frameworks and criteria. We carried out a framework development process integrating contemporary debates in epidemiology, findings from the literature search and synthesis, iterative pilot-testing, and brainstorming and consensus discussions to propose a concise framework to appraise clinical applicability. Results Of the 4622 references retrieved, we identified 26 unique frameworks featuring 21 criteria. Frameworks and criteria varied by scope and level of aggregation of the evidence appraised, target user, and specific area of applicability (internal validity, clinical applicability, external validity, and system applicability). Our proposed Framework Appraising the Clinical Applicability of Studies (FrACAS) classifies studies in three domains (research, practice informing, and practice changing) by examining six criteria sequentially: Validity, Indication-informativeness, Clinical relevance, Originality, Risk-benefit comprehensiveness, and Transposability (VICORT checklist). Conclusions Existing frameworks to applicability vary by scope, target user, and area of applicability. We introduce FrACAS to specifically assess applicability from a clinical perspective. Our framework can be used as a tool for the design, appraisal, and interpretation of epidemiological and clinical studies.
format	article
author	Quoc Dinh Nguyen Erica M. Moodie Philippe Desmarais Robert Goulden Marie-France Forget Eric Peters Sahar Saeed Mark R. Keezer Christina Wolfson
author_facet	Quoc Dinh Nguyen Erica M. Moodie Philippe Desmarais Robert Goulden Marie-France Forget Eric Peters Sahar Saeed Mark R. Keezer Christina Wolfson
author_sort	Quoc Dinh Nguyen
title	Appraising clinical applicability of studies: mapping and synthesis of current frameworks, and proposal of the FrACAS framework and VICORT checklist
title_short	Appraising clinical applicability of studies: mapping and synthesis of current frameworks, and proposal of the FrACAS framework and VICORT checklist
title_full	Appraising clinical applicability of studies: mapping and synthesis of current frameworks, and proposal of the FrACAS framework and VICORT checklist
title_fullStr	Appraising clinical applicability of studies: mapping and synthesis of current frameworks, and proposal of the FrACAS framework and VICORT checklist
title_full_unstemmed	Appraising clinical applicability of studies: mapping and synthesis of current frameworks, and proposal of the FrACAS framework and VICORT checklist
title_sort	appraising clinical applicability of studies: mapping and synthesis of current frameworks, and proposal of the fracas framework and vicort checklist
publisher	BMC
publishDate	2021
url	https://doaj.org/article/07ed91c2d3984d3f9a5f2128199c2b31
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Appraising clinical applicability of studies: mapping and synthesis of current frameworks, and proposal of the FrACAS framework and VICORT checklist

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