Landscape of Circular Ribonucleic Acids in Urological Cancers

The urological malignancies are among the most important neoplastic diseases imposing a significant burden on health care systems globally. The current therapeutic measures for these cancers have unsatisfactory results, and comprehensive knowledge of pathways involved in carcinogenesis and progressi...

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Autor principal:	Sina Rashedi
Formato:	article
Lenguaje:	EN
Publicado:	Urology Research Center 2021
Materias:	circular ribonucleic acids urologic neoplasms prostate neoplasms urinary bladder neoplasms kidney neoplasms Diseases of the genitourinary system. Urology RC870-923
Acceso en línea:	https://doaj.org/article/07f1394fffbf4635b177b0b28c558f2f
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spelling	oai:doaj.org-article:07f1394fffbf4635b177b0b28c558f2f2021-11-30T06:56:11ZLandscape of Circular Ribonucleic Acids in Urological Cancers10.22034/TRU.2021.286351.10672717-042Xhttps://doaj.org/article/07f1394fffbf4635b177b0b28c558f2f2021-05-01T00:00:00Zhttps://www.transresurology.com/article_131127.htmlhttps://doaj.org/toc/2717-042XThe urological malignancies are among the most important neoplastic diseases imposing a significant burden on health care systems globally. The current therapeutic measures for these cancers have unsatisfactory results, and comprehensive knowledge of pathways involved in carcinogenesis and progression of these cancers is of utmost importance. Circular Ribonucleic Acids (circRNAs) are a class of non-coding RNAs characterized by their single-stranded covalently closed loops, exert their regulatory effects mainly by sponging the microRNAs (miRNAs) associated with the regulation of gene expression. In the past few years, several circRNAs have been identified to be implicated in the malignancies of the urinary system. A number of these circRNAs are involved in the common carcinogenic pathways, such as MAPK/ERK, TGF-β, and PI3K-Akt pathways. However, further studies are required to ascertain the exact mechanism of numerous circRNAs in urological cancers and determine their diagnostic, prognostic, and therapeutic roles in patients with these cancers.Sina Rashedi Urology Research Centerarticlecircular ribonucleic acidsurologic neoplasmsprostate neoplasmsurinary bladder neoplasmskidney neoplasmsDiseases of the genitourinary system. UrologyRC870-923ENTranslational Research in Urology, Vol 3, Iss 2, Pp 45-47 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	circular ribonucleic acids urologic neoplasms prostate neoplasms urinary bladder neoplasms kidney neoplasms Diseases of the genitourinary system. Urology RC870-923
spellingShingle	circular ribonucleic acids urologic neoplasms prostate neoplasms urinary bladder neoplasms kidney neoplasms Diseases of the genitourinary system. Urology RC870-923 Sina Rashedi Landscape of Circular Ribonucleic Acids in Urological Cancers
description	The urological malignancies are among the most important neoplastic diseases imposing a significant burden on health care systems globally. The current therapeutic measures for these cancers have unsatisfactory results, and comprehensive knowledge of pathways involved in carcinogenesis and progression of these cancers is of utmost importance. Circular Ribonucleic Acids (circRNAs) are a class of non-coding RNAs characterized by their single-stranded covalently closed loops, exert their regulatory effects mainly by sponging the microRNAs (miRNAs) associated with the regulation of gene expression. In the past few years, several circRNAs have been identified to be implicated in the malignancies of the urinary system. A number of these circRNAs are involved in the common carcinogenic pathways, such as MAPK/ERK, TGF-β, and PI3K-Akt pathways. However, further studies are required to ascertain the exact mechanism of numerous circRNAs in urological cancers and determine their diagnostic, prognostic, and therapeutic roles in patients with these cancers.
format	article
author	Sina Rashedi
author_facet	Sina Rashedi
author_sort	Sina Rashedi
title	Landscape of Circular Ribonucleic Acids in Urological Cancers
title_short	Landscape of Circular Ribonucleic Acids in Urological Cancers
title_full	Landscape of Circular Ribonucleic Acids in Urological Cancers
title_fullStr	Landscape of Circular Ribonucleic Acids in Urological Cancers
title_full_unstemmed	Landscape of Circular Ribonucleic Acids in Urological Cancers
title_sort	landscape of circular ribonucleic acids in urological cancers
publisher	Urology Research Center
publishDate	2021
url	https://doaj.org/article/07f1394fffbf4635b177b0b28c558f2f
work_keys_str_mv	AT sinarashedi landscapeofcircularribonucleicacidsinurologicalcancers
_version_	1718406725275484160

Landscape of Circular Ribonucleic Acids in Urological Cancers

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