Photodynamic diagnosis in upper urinary tract urothelial carcinoma: A systematic review

Objective: To assess the diagnostic accuracy and safety of photodynamic diagnosis (PDD) in upper urinary tract urothelial carcinoma (UUTUC). Materials and methods: A systematic literature search was conducted. Included studies were assessed for the risks of bias and quality using appropriate tools....

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Elsawi Osman, Ziad Alnaib, Nitya Kumar
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2017
Materias:	Upper tract TCC Photodynamic diagnosis Blue light detection 5-Aminolaevulinic Photodynamic ureteroscopy Diseases of the genitourinary system. Urology RC870-923
Acceso en línea:	https://doaj.org/article/07f44d966f584f7498f3fbcbd2c560e8
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:07f44d966f584f7498f3fbcbd2c560e8
record_format	dspace
spelling	oai:doaj.org-article:07f44d966f584f7498f3fbcbd2c560e82021-12-02T10:50:51ZPhotodynamic diagnosis in upper urinary tract urothelial carcinoma: A systematic review2090-598X10.1016/j.aju.2017.01.003https://doaj.org/article/07f44d966f584f7498f3fbcbd2c560e82017-06-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2090598X17300074https://doaj.org/toc/2090-598XObjective: To assess the diagnostic accuracy and safety of photodynamic diagnosis (PDD) in upper urinary tract urothelial carcinoma (UUTUC). Materials and methods: A systematic literature search was conducted. Included studies were assessed for the risks of bias and quality using appropriate tools. Dedicated data extraction forms were used. Diagnostic accuracy in terms of sensitivity and specificity were quoted whenever provided by individual studies. A combined toxicity profile of 5-aminolevulinic acid (5ALA) was given after reviewing individual studies. Results: In all, 17 studies were identified. After screening seven studies were included involving a total of 194 patients. None of the studies were randomised. All the available studies were of low-to-moderate quality. The largest available study, with 106 patients, reported a sensitivity of 95.8% and 53.5% for PDD and white-light (WL) ureterorenoscopy (URS) respectively, with a statistically significant difference. The specificity was 96.6% for PDD and 95.2% for WL-URS with no statistical significance. PDD showed better ability in detecting carcinoma in situ and dysplasia. One study compared PDD to computed tomography urogram (CTU) and found PDD to have better sensitivity and statistically significantly better specificity. 5ALA-associated toxicity was minor in nature and hypotension was the most common adverse event. Conclusion: PDD in UUTUC appears to be more accurate than WL-URS and CTU, with no significant toxicity. Larger scale randomised trials are needed.Elsawi OsmanZiad AlnaibNitya KumarTaylor & Francis GrouparticleUpper tract TCCPhotodynamic diagnosisBlue light detection5-AminolaevulinicPhotodynamic ureteroscopyDiseases of the genitourinary system. UrologyRC870-923ENArab Journal of Urology, Vol 15, Iss 2, Pp 100-109 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Upper tract TCC Photodynamic diagnosis Blue light detection 5-Aminolaevulinic Photodynamic ureteroscopy Diseases of the genitourinary system. Urology RC870-923
spellingShingle	Upper tract TCC Photodynamic diagnosis Blue light detection 5-Aminolaevulinic Photodynamic ureteroscopy Diseases of the genitourinary system. Urology RC870-923 Elsawi Osman Ziad Alnaib Nitya Kumar Photodynamic diagnosis in upper urinary tract urothelial carcinoma: A systematic review
description	Objective: To assess the diagnostic accuracy and safety of photodynamic diagnosis (PDD) in upper urinary tract urothelial carcinoma (UUTUC). Materials and methods: A systematic literature search was conducted. Included studies were assessed for the risks of bias and quality using appropriate tools. Dedicated data extraction forms were used. Diagnostic accuracy in terms of sensitivity and specificity were quoted whenever provided by individual studies. A combined toxicity profile of 5-aminolevulinic acid (5ALA) was given after reviewing individual studies. Results: In all, 17 studies were identified. After screening seven studies were included involving a total of 194 patients. None of the studies were randomised. All the available studies were of low-to-moderate quality. The largest available study, with 106 patients, reported a sensitivity of 95.8% and 53.5% for PDD and white-light (WL) ureterorenoscopy (URS) respectively, with a statistically significant difference. The specificity was 96.6% for PDD and 95.2% for WL-URS with no statistical significance. PDD showed better ability in detecting carcinoma in situ and dysplasia. One study compared PDD to computed tomography urogram (CTU) and found PDD to have better sensitivity and statistically significantly better specificity. 5ALA-associated toxicity was minor in nature and hypotension was the most common adverse event. Conclusion: PDD in UUTUC appears to be more accurate than WL-URS and CTU, with no significant toxicity. Larger scale randomised trials are needed.
format	article
author	Elsawi Osman Ziad Alnaib Nitya Kumar
author_facet	Elsawi Osman Ziad Alnaib Nitya Kumar
author_sort	Elsawi Osman
title	Photodynamic diagnosis in upper urinary tract urothelial carcinoma: A systematic review
title_short	Photodynamic diagnosis in upper urinary tract urothelial carcinoma: A systematic review
title_full	Photodynamic diagnosis in upper urinary tract urothelial carcinoma: A systematic review
title_fullStr	Photodynamic diagnosis in upper urinary tract urothelial carcinoma: A systematic review
title_full_unstemmed	Photodynamic diagnosis in upper urinary tract urothelial carcinoma: A systematic review
title_sort	photodynamic diagnosis in upper urinary tract urothelial carcinoma: a systematic review
publisher	Taylor & Francis Group
publishDate	2017
url	https://doaj.org/article/07f44d966f584f7498f3fbcbd2c560e8
work_keys_str_mv	AT elsawiosman photodynamicdiagnosisinupperurinarytracturothelialcarcinomaasystematicreview AT ziadalnaib photodynamicdiagnosisinupperurinarytracturothelialcarcinomaasystematicreview AT nityakumar photodynamicdiagnosisinupperurinarytracturothelialcarcinomaasystematicreview
_version_	1718396510625857536

Photodynamic diagnosis in upper urinary tract urothelial carcinoma: A systematic review

Ejemplares similares