Reconstituting development of pancreatic intraepithelial neoplasia from primary human pancreas duct cells

Reconstituting development of pancreatic intraepithelial neoplasia from primary human pancreas duct cells

Models of human pancreatic intraepithelial neoplasia (PanIN) development do not exist. Here, the authors induce oncogenicKRAS and mutations in CDKN2A, SMAD4 and TP53in primary human pancreatic cells to generate a PanIN model that recapitulates molecular and pathologic features of native PanINs.

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Detalles Bibliográficos
Autores principales: Jonghyeob Lee, Emily R. Snyder, Yinghua Liu, Xueying Gu, Jing Wang, Brittany M. Flowers, Yoo Jung Kim, Sangbin Park, Gregory L. Szot, Ralph H. Hruban, Teri A. Longacre, Seung K. Kim
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Science
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Acceso en línea:https://doaj.org/article/07f5f64889bc4267b1acdb73c8a62eac
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Descripción
Sumario:Models of human pancreatic intraepithelial neoplasia (PanIN) development do not exist. Here, the authors induce oncogenicKRAS and mutations in CDKN2A, SMAD4 and TP53in primary human pancreatic cells to generate a PanIN model that recapitulates molecular and pathologic features of native PanINs.

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