Reconstituting development of pancreatic intraepithelial neoplasia from primary human pancreas duct cells

Models of human pancreatic intraepithelial neoplasia (PanIN) development do not exist. Here, the authors induce oncogenicKRAS and mutations in CDKN2A, SMAD4 and TP53in primary human pancreatic cells to generate a PanIN model that recapitulates molecular and pathologic features of native PanINs.

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Autores principales:	Jonghyeob Lee, Emily R. Snyder, Yinghua Liu, Xueying Gu, Jing Wang, Brittany M. Flowers, Yoo Jung Kim, Sangbin Park, Gregory L. Szot, Ralph H. Hruban, Teri A. Longacre, Seung K. Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/07f5f64889bc4267b1acdb73c8a62eac
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spelling	oai:doaj.org-article:07f5f64889bc4267b1acdb73c8a62eac2021-12-02T14:42:16ZReconstituting development of pancreatic intraepithelial neoplasia from primary human pancreas duct cells10.1038/ncomms146862041-1723https://doaj.org/article/07f5f64889bc4267b1acdb73c8a62eac2017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14686https://doaj.org/toc/2041-1723Models of human pancreatic intraepithelial neoplasia (PanIN) development do not exist. Here, the authors induce oncogenicKRAS and mutations in CDKN2A, SMAD4 and TP53in primary human pancreatic cells to generate a PanIN model that recapitulates molecular and pathologic features of native PanINs.Jonghyeob LeeEmily R. SnyderYinghua LiuXueying GuJing WangBrittany M. FlowersYoo Jung KimSangbin ParkGregory L. SzotRalph H. HrubanTeri A. LongacreSeung K. KimNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jonghyeob Lee Emily R. Snyder Yinghua Liu Xueying Gu Jing Wang Brittany M. Flowers Yoo Jung Kim Sangbin Park Gregory L. Szot Ralph H. Hruban Teri A. Longacre Seung K. Kim Reconstituting development of pancreatic intraepithelial neoplasia from primary human pancreas duct cells
description	Models of human pancreatic intraepithelial neoplasia (PanIN) development do not exist. Here, the authors induce oncogenicKRAS and mutations in CDKN2A, SMAD4 and TP53in primary human pancreatic cells to generate a PanIN model that recapitulates molecular and pathologic features of native PanINs.
format	article
author	Jonghyeob Lee Emily R. Snyder Yinghua Liu Xueying Gu Jing Wang Brittany M. Flowers Yoo Jung Kim Sangbin Park Gregory L. Szot Ralph H. Hruban Teri A. Longacre Seung K. Kim
author_facet	Jonghyeob Lee Emily R. Snyder Yinghua Liu Xueying Gu Jing Wang Brittany M. Flowers Yoo Jung Kim Sangbin Park Gregory L. Szot Ralph H. Hruban Teri A. Longacre Seung K. Kim
author_sort	Jonghyeob Lee
title	Reconstituting development of pancreatic intraepithelial neoplasia from primary human pancreas duct cells
title_short	Reconstituting development of pancreatic intraepithelial neoplasia from primary human pancreas duct cells
title_full	Reconstituting development of pancreatic intraepithelial neoplasia from primary human pancreas duct cells
title_fullStr	Reconstituting development of pancreatic intraepithelial neoplasia from primary human pancreas duct cells
title_full_unstemmed	Reconstituting development of pancreatic intraepithelial neoplasia from primary human pancreas duct cells
title_sort	reconstituting development of pancreatic intraepithelial neoplasia from primary human pancreas duct cells
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/07f5f64889bc4267b1acdb73c8a62eac
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_version_	1718389730925608960

Reconstituting development of pancreatic intraepithelial neoplasia from primary human pancreas duct cells

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