Targeting galectin-3 with a high-affinity antibody for inhibition of high-grade serous ovarian cancer and other MUC16/CA-125-expressing malignancies

Targeting galectin-3 with a high-affinity antibody for inhibition of high-grade serous ovarian cancer and other MUC16/CA-125-expressing malignancies

Abstract The lectin, galectin-3 (Gal3), has been implicated in a variety of inflammatory and oncogenic processes, including tumor growth, invasion, and metastasis. The interactions of Gal3 and MUC16 represent a potential targetable pathway for the treatment of MUC16-expressing malignancies. We found...

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Main Authors: Marina Stasenko, Evan Smith, Oladapo Yeku, Kay J. Park, Ian Laster, Kwangkook Lee, Sven Walderich, Elizabeth Spriggs, Bo Rueda, Britta Weigelt, Dmitriy Zamarin, Thapi Dharma Rao, David R. Spriggs
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/07f8316150054d388efdf8ddb85cc8eb
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