The relationship between common mental disorders and incident diabetes among participants in the Kerala Diabetes Prevention Program (K-DPP).

This study aims to describe the prevalence of depression and anxiety among a population sample of people at high risk for type 2 diabetes in Kerala, India, and examine the relationship between depressive symptoms, anxiety, and incident Type 2 Diabetes Mellitus (T2DM) over a two-year period. We used...

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Autores principales:	Leslie C M Johnson, Allissa Desloge, Thirunavukkarasu Sathish, Emily D Williams, Pilvikki Absetz, Tilahun Haregu, Jeroen De Man, Kavumpurathu Raman Thankappan, Brian Oldenburg
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/07f85d595a154fa184d268df5b84e12c
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spelling	oai:doaj.org-article:07f85d595a154fa184d268df5b84e12c2021-12-02T20:06:28ZThe relationship between common mental disorders and incident diabetes among participants in the Kerala Diabetes Prevention Program (K-DPP).1932-620310.1371/journal.pone.0255217https://doaj.org/article/07f85d595a154fa184d268df5b84e12c2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0255217https://doaj.org/toc/1932-6203This study aims to describe the prevalence of depression and anxiety among a population sample of people at high risk for type 2 diabetes in Kerala, India, and examine the relationship between depressive symptoms, anxiety, and incident Type 2 Diabetes Mellitus (T2DM) over a two-year period. We used data from the Kerala Diabetes Prevention Program, a cluster-randomized controlled trial for diabetes prevention among 1007 high-risk individuals. The prevalence of depression and anxiety were estimated using the 9-item Patient Health Questionnaire and the Generalized Anxiety Disorder 7-item scale, respectively. We calculated proportions for depression and anxiety and performed generalized estimating equations (GEE) to examine the relationship between baseline mental health status and incident T2DM. The prevalence of depression and anxiety at baseline were 7.5% and 5.5%, respectively. Compared with those reporting none/low symptoms, the odds ratio for incident diabetes was 1.07 (95% CI 0.54-2.12) for participants with moderate to severe depression and 0.73 (95% CI 0.23-2.28) for participants with moderate to severe anxiety, after adjusting for potential confounders. Our findings suggest that the prevalence of depression and anxiety were higher than those previously reported in the general population in India. However, among this sample of community-based adults at high risk of developing T2DM, the presence of moderate to severe depression and/or anxiety symptoms was not significantly associated with the risk of developing T2DM. Trial registration: Australia and New Zealand Clinical Trials Registry ACTRN12611000262909. Registered 10 March 2011.Leslie C M JohnsonAllissa DeslogeThirunavukkarasu SathishEmily D WilliamsPilvikki AbsetzTilahun HareguJeroen De ManKavumpurathu Raman ThankappanBrian OldenburgPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0255217 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Leslie C M Johnson Allissa Desloge Thirunavukkarasu Sathish Emily D Williams Pilvikki Absetz Tilahun Haregu Jeroen De Man Kavumpurathu Raman Thankappan Brian Oldenburg The relationship between common mental disorders and incident diabetes among participants in the Kerala Diabetes Prevention Program (K-DPP).
description	This study aims to describe the prevalence of depression and anxiety among a population sample of people at high risk for type 2 diabetes in Kerala, India, and examine the relationship between depressive symptoms, anxiety, and incident Type 2 Diabetes Mellitus (T2DM) over a two-year period. We used data from the Kerala Diabetes Prevention Program, a cluster-randomized controlled trial for diabetes prevention among 1007 high-risk individuals. The prevalence of depression and anxiety were estimated using the 9-item Patient Health Questionnaire and the Generalized Anxiety Disorder 7-item scale, respectively. We calculated proportions for depression and anxiety and performed generalized estimating equations (GEE) to examine the relationship between baseline mental health status and incident T2DM. The prevalence of depression and anxiety at baseline were 7.5% and 5.5%, respectively. Compared with those reporting none/low symptoms, the odds ratio for incident diabetes was 1.07 (95% CI 0.54-2.12) for participants with moderate to severe depression and 0.73 (95% CI 0.23-2.28) for participants with moderate to severe anxiety, after adjusting for potential confounders. Our findings suggest that the prevalence of depression and anxiety were higher than those previously reported in the general population in India. However, among this sample of community-based adults at high risk of developing T2DM, the presence of moderate to severe depression and/or anxiety symptoms was not significantly associated with the risk of developing T2DM. Trial registration: Australia and New Zealand Clinical Trials Registry ACTRN12611000262909. Registered 10 March 2011.
format	article
author	Leslie C M Johnson Allissa Desloge Thirunavukkarasu Sathish Emily D Williams Pilvikki Absetz Tilahun Haregu Jeroen De Man Kavumpurathu Raman Thankappan Brian Oldenburg
author_facet	Leslie C M Johnson Allissa Desloge Thirunavukkarasu Sathish Emily D Williams Pilvikki Absetz Tilahun Haregu Jeroen De Man Kavumpurathu Raman Thankappan Brian Oldenburg
author_sort	Leslie C M Johnson
title	The relationship between common mental disorders and incident diabetes among participants in the Kerala Diabetes Prevention Program (K-DPP).
title_short	The relationship between common mental disorders and incident diabetes among participants in the Kerala Diabetes Prevention Program (K-DPP).
title_full	The relationship between common mental disorders and incident diabetes among participants in the Kerala Diabetes Prevention Program (K-DPP).
title_fullStr	The relationship between common mental disorders and incident diabetes among participants in the Kerala Diabetes Prevention Program (K-DPP).
title_full_unstemmed	The relationship between common mental disorders and incident diabetes among participants in the Kerala Diabetes Prevention Program (K-DPP).
title_sort	relationship between common mental disorders and incident diabetes among participants in the kerala diabetes prevention program (k-dpp).
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/07f85d595a154fa184d268df5b84e12c
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The relationship between common mental disorders and incident diabetes among participants in the Kerala Diabetes Prevention Program (K-DPP).

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