THE CYTOKINES SYNTHESIS IN VITRO IN THE TICK-BORNE ENCEPHALITIS VIRUS INFECTED CELLS AND IN THE PRESENCE OF INACTIVATED VACCINE

Abstract. Tick-borne encephalitis (TBE) is severe neuroinfectious disease with involvement of immune mechanisms in pathogenesis. Comparative analysis of synthesis of key cytokines had been performed for the TBE virus (TBEV) infected cells and in the presence of inactivated vaccine against TBE in vit...

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Autores principales:	M. V. Mesentseva, I. F. Аntoshina, O. V. Мorozova
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2014
Materias:	tick-borne encephalitis virus inactivated vaccine against tick-borne encephalitis cytokines Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/07f9913a010946e5a7b49d0226067a17
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spelling	oai:doaj.org-article:07f9913a010946e5a7b49d0226067a172021-11-22T07:09:46ZTHE CYTOKINES SYNTHESIS IN VITRO IN THE TICK-BORNE ENCEPHALITIS VIRUS INFECTED CELLS AND IN THE PRESENCE OF INACTIVATED VACCINE2220-76192313-739810.15789/2220-7619-2014-1-37-42https://doaj.org/article/07f9913a010946e5a7b49d0226067a172014-07-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/155https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398Abstract. Tick-borne encephalitis (TBE) is severe neuroinfectious disease with involvement of immune mechanisms in pathogenesis. Comparative analysis of synthesis of key cytokines had been performed for the TBE virus (TBEV) infected cells and in the presence of inactivated vaccine against TBE in vitro. Persistent TBEV infection of immortal tissue culture of human larynx cancer cells caused transcription activation of interferons IFNα, IFNγ, IFNλ1, interleukins IL-1β, IL-2, IL-4, IL-8, IL-10, IL-12, tumour necrosis factor TNFα as well as one of apoptosis factors Fas. Comparison of transcription and production of cytokines revealed that the TBEV infection resulted in posttranscription Th1 shift of cytokine response. In the presence of inactivated vaccine against TBE based on the same strain Sofjin of the TBEV activation of transcription of cytokines IFNα, IFNλ1, IL-4, IL-10 was also observed as after the TBEV infection that together with an additional stimulation of GM-CSF production might serve as an evidence of Th2 response. Involvement of IFNIII type (IFNλ1) both during persistent infection and after addition of inactivated vaccines was found in the first time. Differences in dynamics of cytokines IL-2, IL-8, IL-10, IL-12, TNFα response during the TBEV infection and in the presence of inactivated vaccine are described.M. V. MesentsevaI. F. АntoshinaO. V. МorozovaSankt-Peterburg : NIIÈM imeni Pasteraarticletick-borne encephalitis virusinactivated vaccine against tick-borne encephalitiscytokinesInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 4, Iss 1, Pp 37-42 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	tick-borne encephalitis virus inactivated vaccine against tick-borne encephalitis cytokines Infectious and parasitic diseases RC109-216
spellingShingle	tick-borne encephalitis virus inactivated vaccine against tick-borne encephalitis cytokines Infectious and parasitic diseases RC109-216 M. V. Mesentseva I. F. Аntoshina O. V. Мorozova THE CYTOKINES SYNTHESIS IN VITRO IN THE TICK-BORNE ENCEPHALITIS VIRUS INFECTED CELLS AND IN THE PRESENCE OF INACTIVATED VACCINE
description	Abstract. Tick-borne encephalitis (TBE) is severe neuroinfectious disease with involvement of immune mechanisms in pathogenesis. Comparative analysis of synthesis of key cytokines had been performed for the TBE virus (TBEV) infected cells and in the presence of inactivated vaccine against TBE in vitro. Persistent TBEV infection of immortal tissue culture of human larynx cancer cells caused transcription activation of interferons IFNα, IFNγ, IFNλ1, interleukins IL-1β, IL-2, IL-4, IL-8, IL-10, IL-12, tumour necrosis factor TNFα as well as one of apoptosis factors Fas. Comparison of transcription and production of cytokines revealed that the TBEV infection resulted in posttranscription Th1 shift of cytokine response. In the presence of inactivated vaccine against TBE based on the same strain Sofjin of the TBEV activation of transcription of cytokines IFNα, IFNλ1, IL-4, IL-10 was also observed as after the TBEV infection that together with an additional stimulation of GM-CSF production might serve as an evidence of Th2 response. Involvement of IFNIII type (IFNλ1) both during persistent infection and after addition of inactivated vaccines was found in the first time. Differences in dynamics of cytokines IL-2, IL-8, IL-10, IL-12, TNFα response during the TBEV infection and in the presence of inactivated vaccine are described.
format	article
author	M. V. Mesentseva I. F. Аntoshina O. V. Мorozova
author_facet	M. V. Mesentseva I. F. Аntoshina O. V. Мorozova
author_sort	M. V. Mesentseva
title	THE CYTOKINES SYNTHESIS IN VITRO IN THE TICK-BORNE ENCEPHALITIS VIRUS INFECTED CELLS AND IN THE PRESENCE OF INACTIVATED VACCINE
title_short	THE CYTOKINES SYNTHESIS IN VITRO IN THE TICK-BORNE ENCEPHALITIS VIRUS INFECTED CELLS AND IN THE PRESENCE OF INACTIVATED VACCINE
title_full	THE CYTOKINES SYNTHESIS IN VITRO IN THE TICK-BORNE ENCEPHALITIS VIRUS INFECTED CELLS AND IN THE PRESENCE OF INACTIVATED VACCINE
title_fullStr	THE CYTOKINES SYNTHESIS IN VITRO IN THE TICK-BORNE ENCEPHALITIS VIRUS INFECTED CELLS AND IN THE PRESENCE OF INACTIVATED VACCINE
title_full_unstemmed	THE CYTOKINES SYNTHESIS IN VITRO IN THE TICK-BORNE ENCEPHALITIS VIRUS INFECTED CELLS AND IN THE PRESENCE OF INACTIVATED VACCINE
title_sort	cytokines synthesis in vitro in the tick-borne encephalitis virus infected cells and in the presence of inactivated vaccine
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2014
url	https://doaj.org/article/07f9913a010946e5a7b49d0226067a17
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THE CYTOKINES SYNTHESIS IN VITRO IN THE TICK-BORNE ENCEPHALITIS VIRUS INFECTED CELLS AND IN THE PRESENCE OF INACTIVATED VACCINE

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