Dysregulation of REV-ERBα impairs GABAergic function and promotes epileptic seizures in preclinical models

Rev-erbα is a known regulator of the circadian clock. Here, the authors show that Rev-erbα is also a regulator of synaptic dysfunction in preclinical models of epilepsy.

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Autores principales: Tianpeng Zhang, Fangjun Yu, Haiman Xu, Min Chen, Xun Chen, Lianxia Guo, Cui Zhou, Yuting Xu, Fei Wang, Jiandong Yu, Baojian Wu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/07fc6d12c64c4430ba98b16fc90d9274
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Sumario:Rev-erbα is a known regulator of the circadian clock. Here, the authors show that Rev-erbα is also a regulator of synaptic dysfunction in preclinical models of epilepsy.