Dysregulation of REV-ERBα impairs GABAergic function and promotes epileptic seizures in preclinical models

Rev-erbα is a known regulator of the circadian clock. Here, the authors show that Rev-erbα is also a regulator of synaptic dysfunction in preclinical models of epilepsy.

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Autores principales:	Tianpeng Zhang, Fangjun Yu, Haiman Xu, Min Chen, Xun Chen, Lianxia Guo, Cui Zhou, Yuting Xu, Fei Wang, Jiandong Yu, Baojian Wu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/07fc6d12c64c4430ba98b16fc90d9274
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spelling	oai:doaj.org-article:07fc6d12c64c4430ba98b16fc90d92742021-12-02T11:02:37ZDysregulation of REV-ERBα impairs GABAergic function and promotes epileptic seizures in preclinical models10.1038/s41467-021-21477-w2041-1723https://doaj.org/article/07fc6d12c64c4430ba98b16fc90d92742021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21477-whttps://doaj.org/toc/2041-1723Rev-erbα is a known regulator of the circadian clock. Here, the authors show that Rev-erbα is also a regulator of synaptic dysfunction in preclinical models of epilepsy.Tianpeng ZhangFangjun YuHaiman XuMin ChenXun ChenLianxia GuoCui ZhouYuting XuFei WangJiandong YuBaojian WuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tianpeng Zhang Fangjun Yu Haiman Xu Min Chen Xun Chen Lianxia Guo Cui Zhou Yuting Xu Fei Wang Jiandong Yu Baojian Wu Dysregulation of REV-ERBα impairs GABAergic function and promotes epileptic seizures in preclinical models
description	Rev-erbα is a known regulator of the circadian clock. Here, the authors show that Rev-erbα is also a regulator of synaptic dysfunction in preclinical models of epilepsy.
format	article
author	Tianpeng Zhang Fangjun Yu Haiman Xu Min Chen Xun Chen Lianxia Guo Cui Zhou Yuting Xu Fei Wang Jiandong Yu Baojian Wu
author_facet	Tianpeng Zhang Fangjun Yu Haiman Xu Min Chen Xun Chen Lianxia Guo Cui Zhou Yuting Xu Fei Wang Jiandong Yu Baojian Wu
author_sort	Tianpeng Zhang
title	Dysregulation of REV-ERBα impairs GABAergic function and promotes epileptic seizures in preclinical models
title_short	Dysregulation of REV-ERBα impairs GABAergic function and promotes epileptic seizures in preclinical models
title_full	Dysregulation of REV-ERBα impairs GABAergic function and promotes epileptic seizures in preclinical models
title_fullStr	Dysregulation of REV-ERBα impairs GABAergic function and promotes epileptic seizures in preclinical models
title_full_unstemmed	Dysregulation of REV-ERBα impairs GABAergic function and promotes epileptic seizures in preclinical models
title_sort	dysregulation of rev-erbα impairs gabaergic function and promotes epileptic seizures in preclinical models
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/07fc6d12c64c4430ba98b16fc90d9274
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Dysregulation of REV-ERBα impairs GABAergic function and promotes epileptic seizures in preclinical models

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