Theoretical Evaluation of the Impact of Hyperthermia in Combination with Radiation Therapy in an Artificial Immune—Tumor-Ecosystem

There is some evidence that radiotherapy (RT) can trigger anti-tumor immune responses. In addition, hyperthermia (HT) is known to be a tumor cell radio-sensitizer. How HT could enhance the anti-tumor immune response produced by RT is still an open question. The aim of this study is the evaluation of...

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Autores principales:	Stephan Scheidegger, Sergio Mingo Barba, Udo S. Gaipl
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	systems medicine immune system in silico perceptron antigen pattern danger signal fractionation Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/07feb4da1aae4efb8a1818d5431d7038
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spelling	oai:doaj.org-article:07feb4da1aae4efb8a1818d5431d70382021-11-25T17:03:44ZTheoretical Evaluation of the Impact of Hyperthermia in Combination with Radiation Therapy in an Artificial Immune—Tumor-Ecosystem10.3390/cancers132257642072-6694https://doaj.org/article/07feb4da1aae4efb8a1818d5431d70382021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/22/5764https://doaj.org/toc/2072-6694There is some evidence that radiotherapy (RT) can trigger anti-tumor immune responses. In addition, hyperthermia (HT) is known to be a tumor cell radio-sensitizer. How HT could enhance the anti-tumor immune response produced by RT is still an open question. The aim of this study is the evaluation of potential dynamic effects regarding the adaptive immune response induced by different combinations of RT fractions with HT. The adaptive immune system is considered as a trainable unit (perceptron) which compares danger signals released by necrotic or apoptotic cell death with the presence of tumor- and host tissue cell population-specific molecular patterns (antigens). To mimic the changes produced by HT such as cell radio-sensitization or increase of the blood perfusion after hyperthermia, simplistic biophysical models were included. To study the effectiveness of the different RT+HT treatments, the Tumor Control Probability (TCP) was calculated. In the considered scenarios, the major effect of HT is related to the enhancement of the cell radio-sensitivity while perfusion or heat-based effects on the immune system seem to contribute less. Moreover, no tumor vaccination effect has been observed. In the presented scenarios, HT boosts the RT cell killing but it does not fundamentally change the anti-tumor immune response.Stephan ScheideggerSergio Mingo BarbaUdo S. GaiplMDPI AGarticlesystems medicineimmune system in silicoperceptronantigen patterndanger signalfractionationNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5764, p 5764 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	systems medicine immune system in silico perceptron antigen pattern danger signal fractionation Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	systems medicine immune system in silico perceptron antigen pattern danger signal fractionation Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Stephan Scheidegger Sergio Mingo Barba Udo S. Gaipl Theoretical Evaluation of the Impact of Hyperthermia in Combination with Radiation Therapy in an Artificial Immune—Tumor-Ecosystem
description	There is some evidence that radiotherapy (RT) can trigger anti-tumor immune responses. In addition, hyperthermia (HT) is known to be a tumor cell radio-sensitizer. How HT could enhance the anti-tumor immune response produced by RT is still an open question. The aim of this study is the evaluation of potential dynamic effects regarding the adaptive immune response induced by different combinations of RT fractions with HT. The adaptive immune system is considered as a trainable unit (perceptron) which compares danger signals released by necrotic or apoptotic cell death with the presence of tumor- and host tissue cell population-specific molecular patterns (antigens). To mimic the changes produced by HT such as cell radio-sensitization or increase of the blood perfusion after hyperthermia, simplistic biophysical models were included. To study the effectiveness of the different RT+HT treatments, the Tumor Control Probability (TCP) was calculated. In the considered scenarios, the major effect of HT is related to the enhancement of the cell radio-sensitivity while perfusion or heat-based effects on the immune system seem to contribute less. Moreover, no tumor vaccination effect has been observed. In the presented scenarios, HT boosts the RT cell killing but it does not fundamentally change the anti-tumor immune response.
format	article
author	Stephan Scheidegger Sergio Mingo Barba Udo S. Gaipl
author_facet	Stephan Scheidegger Sergio Mingo Barba Udo S. Gaipl
author_sort	Stephan Scheidegger
title	Theoretical Evaluation of the Impact of Hyperthermia in Combination with Radiation Therapy in an Artificial Immune—Tumor-Ecosystem
title_short	Theoretical Evaluation of the Impact of Hyperthermia in Combination with Radiation Therapy in an Artificial Immune—Tumor-Ecosystem
title_full	Theoretical Evaluation of the Impact of Hyperthermia in Combination with Radiation Therapy in an Artificial Immune—Tumor-Ecosystem
title_fullStr	Theoretical Evaluation of the Impact of Hyperthermia in Combination with Radiation Therapy in an Artificial Immune—Tumor-Ecosystem
title_full_unstemmed	Theoretical Evaluation of the Impact of Hyperthermia in Combination with Radiation Therapy in an Artificial Immune—Tumor-Ecosystem
title_sort	theoretical evaluation of the impact of hyperthermia in combination with radiation therapy in an artificial immune—tumor-ecosystem
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/07feb4da1aae4efb8a1818d5431d7038
work_keys_str_mv	AT stephanscheidegger theoreticalevaluationoftheimpactofhyperthermiaincombinationwithradiationtherapyinanartificialimmunetumorecosystem AT sergiomingobarba theoreticalevaluationoftheimpactofhyperthermiaincombinationwithradiationtherapyinanartificialimmunetumorecosystem AT udosgaipl theoreticalevaluationoftheimpactofhyperthermiaincombinationwithradiationtherapyinanartificialimmunetumorecosystem
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Theoretical Evaluation of the Impact of Hyperthermia in Combination with Radiation Therapy in an Artificial Immune—Tumor-Ecosystem

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