Changes of antibiotic prescribing pattern and its resistance to E. Coli in South Korea: a 12-year retrospective observational study

Abstract In the present study, we investigated the pattern of changes in antibiotic prescription and antimicrobial resistance (AMR) in Escherichia coli in South Korea between 2007 and 2018. We collected data related to antibiotic prescription and AMR in E. coli from the national surveillance system....

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Autores principales:	Geun Woo Lee, Sukhyun Ryu, Juhee Park, Eun Jee Lee, Kwang Jun Lee, Jungyeon Tae, Youngsik Hwang, Dong-Sook Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/08008b5a8b7e4a03836c802979c9696c
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spelling	oai:doaj.org-article:08008b5a8b7e4a03836c802979c9696c2021-12-02T13:19:20ZChanges of antibiotic prescribing pattern and its resistance to E. Coli in South Korea: a 12-year retrospective observational study10.1038/s41598-021-84450-z2045-2322https://doaj.org/article/08008b5a8b7e4a03836c802979c9696c2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84450-zhttps://doaj.org/toc/2045-2322Abstract In the present study, we investigated the pattern of changes in antibiotic prescription and antimicrobial resistance (AMR) in Escherichia coli in South Korea between 2007 and 2018. We collected data related to antibiotic prescription and AMR in E. coli from the national surveillance system. We used the Mann–Kendall test and Spearman’s correlation to identify the trends of antibiotic prescription and AMR in E. coli and to examine the relationship between them, respectively. Although we noted a significant decreasing trend of ampicillin and gentamicin prescriptions in all medical institutions, we identified a higher level of AMR in long-term care facilities than in other medical institutions. We did not identify a significant positive correlation between ampicillin and gentamicin prescriptions and their resistance in E. coli. However, we found a significant positive correlation between cefotaxime prescription and its resistance in E. coli in hospitals, long-term care facilities, and clinics. Our results strongly suggest that long-term care facilities in South Korea have the potential to sustain AMR epidemics and that more efforts are needed to curb AMR in E. coli. Further epidemiological studies using enhanced AMR surveillance are warranted.Geun Woo LeeSukhyun RyuJuhee ParkEun Jee LeeKwang Jun LeeJungyeon TaeYoungsik HwangDong-Sook KimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Geun Woo Lee Sukhyun Ryu Juhee Park Eun Jee Lee Kwang Jun Lee Jungyeon Tae Youngsik Hwang Dong-Sook Kim Changes of antibiotic prescribing pattern and its resistance to E. Coli in South Korea: a 12-year retrospective observational study
description	Abstract In the present study, we investigated the pattern of changes in antibiotic prescription and antimicrobial resistance (AMR) in Escherichia coli in South Korea between 2007 and 2018. We collected data related to antibiotic prescription and AMR in E. coli from the national surveillance system. We used the Mann–Kendall test and Spearman’s correlation to identify the trends of antibiotic prescription and AMR in E. coli and to examine the relationship between them, respectively. Although we noted a significant decreasing trend of ampicillin and gentamicin prescriptions in all medical institutions, we identified a higher level of AMR in long-term care facilities than in other medical institutions. We did not identify a significant positive correlation between ampicillin and gentamicin prescriptions and their resistance in E. coli. However, we found a significant positive correlation between cefotaxime prescription and its resistance in E. coli in hospitals, long-term care facilities, and clinics. Our results strongly suggest that long-term care facilities in South Korea have the potential to sustain AMR epidemics and that more efforts are needed to curb AMR in E. coli. Further epidemiological studies using enhanced AMR surveillance are warranted.
format	article
author	Geun Woo Lee Sukhyun Ryu Juhee Park Eun Jee Lee Kwang Jun Lee Jungyeon Tae Youngsik Hwang Dong-Sook Kim
author_facet	Geun Woo Lee Sukhyun Ryu Juhee Park Eun Jee Lee Kwang Jun Lee Jungyeon Tae Youngsik Hwang Dong-Sook Kim
author_sort	Geun Woo Lee
title	Changes of antibiotic prescribing pattern and its resistance to E. Coli in South Korea: a 12-year retrospective observational study
title_short	Changes of antibiotic prescribing pattern and its resistance to E. Coli in South Korea: a 12-year retrospective observational study
title_full	Changes of antibiotic prescribing pattern and its resistance to E. Coli in South Korea: a 12-year retrospective observational study
title_fullStr	Changes of antibiotic prescribing pattern and its resistance to E. Coli in South Korea: a 12-year retrospective observational study
title_full_unstemmed	Changes of antibiotic prescribing pattern and its resistance to E. Coli in South Korea: a 12-year retrospective observational study
title_sort	changes of antibiotic prescribing pattern and its resistance to e. coli in south korea: a 12-year retrospective observational study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/08008b5a8b7e4a03836c802979c9696c
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Changes of antibiotic prescribing pattern and its resistance to E. Coli in South Korea: a 12-year retrospective observational study

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