LncRNA XR_001779380 Primes Epithelial Cells for IFN-γ-Mediated Gene Transcription and Facilitates Age-Dependent Intestinal Antimicrobial Defense

Epithelial cells along the mucosal surface provide the front line of defense against luminal pathogen infection in the gastrointestinal tract. These epithelial cells represent an integral component of a highly regulated communication network that can transmit essential signals to cells in the under...

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Autores principales: Ai-Yu Gong, Yang Wang, Min Li, Xin-Tian Zhang, Silu Deng, Jessie M. Chen, Eugene Lu, Nicholas W. Mathy, Gislaine A. Martins, Juliane K. Strauss-Soukup, Xian-Ming Chen
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2021
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Acceso en línea:https://doaj.org/article/0801779eeecf4115bddb57f5ae461f83
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Sumario:Epithelial cells along the mucosal surface provide the front line of defense against luminal pathogen infection in the gastrointestinal tract. These epithelial cells represent an integral component of a highly regulated communication network that can transmit essential signals to cells in the underlying intestinal mucosa that, in turn, serve as targets of mucosal immune mediators.