Punctuated evolution of canonical genomic aberrations in uveal melanoma

Uveal melanoma (UM), the most common primary eye cancer, is strongly linked to mutations in the tumor suppressor BAP1. Here, the authors analyze 151 primary UM samples to find that BAP1 and other canonical genomic aberrations arise in an early punctuated burst followed by neutral tumor evolution.

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Autores principales:	Matthew G. Field, Michael A. Durante, Hima Anbunathan, Louis Z. Cai, Christina L. Decatur, Anne M. Bowcock, Stefan Kurtenbach, J. William Harbour
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/08030f7ca35741a99b1860d184fb1194
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spelling	oai:doaj.org-article:08030f7ca35741a99b1860d184fb11942021-12-02T15:33:42ZPunctuated evolution of canonical genomic aberrations in uveal melanoma10.1038/s41467-017-02428-w2041-1723https://doaj.org/article/08030f7ca35741a99b1860d184fb11942018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02428-whttps://doaj.org/toc/2041-1723Uveal melanoma (UM), the most common primary eye cancer, is strongly linked to mutations in the tumor suppressor BAP1. Here, the authors analyze 151 primary UM samples to find that BAP1 and other canonical genomic aberrations arise in an early punctuated burst followed by neutral tumor evolution.Matthew G. FieldMichael A. DuranteHima AnbunathanLouis Z. CaiChristina L. DecaturAnne M. BowcockStefan KurtenbachJ. William HarbourNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Matthew G. Field Michael A. Durante Hima Anbunathan Louis Z. Cai Christina L. Decatur Anne M. Bowcock Stefan Kurtenbach J. William Harbour Punctuated evolution of canonical genomic aberrations in uveal melanoma
description	Uveal melanoma (UM), the most common primary eye cancer, is strongly linked to mutations in the tumor suppressor BAP1. Here, the authors analyze 151 primary UM samples to find that BAP1 and other canonical genomic aberrations arise in an early punctuated burst followed by neutral tumor evolution.
format	article
author	Matthew G. Field Michael A. Durante Hima Anbunathan Louis Z. Cai Christina L. Decatur Anne M. Bowcock Stefan Kurtenbach J. William Harbour
author_facet	Matthew G. Field Michael A. Durante Hima Anbunathan Louis Z. Cai Christina L. Decatur Anne M. Bowcock Stefan Kurtenbach J. William Harbour
author_sort	Matthew G. Field
title	Punctuated evolution of canonical genomic aberrations in uveal melanoma
title_short	Punctuated evolution of canonical genomic aberrations in uveal melanoma
title_full	Punctuated evolution of canonical genomic aberrations in uveal melanoma
title_fullStr	Punctuated evolution of canonical genomic aberrations in uveal melanoma
title_full_unstemmed	Punctuated evolution of canonical genomic aberrations in uveal melanoma
title_sort	punctuated evolution of canonical genomic aberrations in uveal melanoma
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/08030f7ca35741a99b1860d184fb1194
work_keys_str_mv	AT matthewgfield punctuatedevolutionofcanonicalgenomicaberrationsinuvealmelanoma AT michaeladurante punctuatedevolutionofcanonicalgenomicaberrationsinuvealmelanoma AT himaanbunathan punctuatedevolutionofcanonicalgenomicaberrationsinuvealmelanoma AT louiszcai punctuatedevolutionofcanonicalgenomicaberrationsinuvealmelanoma AT christinaldecatur punctuatedevolutionofcanonicalgenomicaberrationsinuvealmelanoma AT annembowcock punctuatedevolutionofcanonicalgenomicaberrationsinuvealmelanoma AT stefankurtenbach punctuatedevolutionofcanonicalgenomicaberrationsinuvealmelanoma AT jwilliamharbour punctuatedevolutionofcanonicalgenomicaberrationsinuvealmelanoma
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Punctuated evolution of canonical genomic aberrations in uveal melanoma

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