Inflammatory marker changes in a 24-month dietary and physical activity randomised intervention trial in postmenopausal women

Abstract Chronic low-grade inflammation plays a role in the pathogenesis of several chronic diseases including cancer. Physical activity (PA) and diet have been supposed to modulate inflammatory markers. We evaluated the effects of a 24-month dietary and/or PA intervention on plasma levels of pro-in...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	G. Masala, B. Bendinelli, C. Della Bella, M. Assedi, S. Tapinassi, I. Ermini, D. Occhini, M. Castaldo, C. Saieva, S. Caini, M. M. D’Elios, D. Palli
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0803623bd2bb4935ad570f577eab43dd
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0803623bd2bb4935ad570f577eab43dd
record_format	dspace
spelling	oai:doaj.org-article:0803623bd2bb4935ad570f577eab43dd2021-12-02T12:42:28ZInflammatory marker changes in a 24-month dietary and physical activity randomised intervention trial in postmenopausal women10.1038/s41598-020-78796-z2045-2322https://doaj.org/article/0803623bd2bb4935ad570f577eab43dd2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78796-zhttps://doaj.org/toc/2045-2322Abstract Chronic low-grade inflammation plays a role in the pathogenesis of several chronic diseases including cancer. Physical activity (PA) and diet have been supposed to modulate inflammatory markers. We evaluated the effects of a 24-month dietary and/or PA intervention on plasma levels of pro-inflammatory cytokines, a secondary analysis in the DAMA factorial trial. The 234 study participants (healthy postmenopausal women with high breast density, 50–69 years, non smokers, no hormone therapy) were randomised to four arms: (1) isocaloric dietary intervention mainly based on plant-foods; (2) moderate-intensity PA intervention with at least 1 h/week of supervised strenuous activity; (3) both interventions; (4) general recommendations on healthy dietary and PA patterns. Interleukins (IL)-1α, -1β, -6, tumor necrosis factor-α and C-reactive protein were measured at baseline and at the end of the intervention. Intention-to-treat-analyses were carried out using Tobit regression. Although all cytokines tended to increase over time, after 24 months women in the PA intervention (arms 2 + 3) showed lower levels of IL-1α (exp(β) = 0.66; p = 0.04) and IL-6 (exp(β) = 0.70; p = 0.01) in comparison with women in the control group (arms 1 + 4). No effects of the dietary intervention emerged. In healthy postmenopausal women with high breast density a moderate-intensity PA appears to slow the age-related increase of pro-inflammatory cytokines.G. MasalaB. BendinelliC. Della BellaM. AssediS. TapinassiI. ErminiD. OcchiniM. CastaldoC. SaievaS. CainiM. M. D’EliosD. PalliNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q G. Masala B. Bendinelli C. Della Bella M. Assedi S. Tapinassi I. Ermini D. Occhini M. Castaldo C. Saieva S. Caini M. M. D’Elios D. Palli Inflammatory marker changes in a 24-month dietary and physical activity randomised intervention trial in postmenopausal women
description	Abstract Chronic low-grade inflammation plays a role in the pathogenesis of several chronic diseases including cancer. Physical activity (PA) and diet have been supposed to modulate inflammatory markers. We evaluated the effects of a 24-month dietary and/or PA intervention on plasma levels of pro-inflammatory cytokines, a secondary analysis in the DAMA factorial trial. The 234 study participants (healthy postmenopausal women with high breast density, 50–69 years, non smokers, no hormone therapy) were randomised to four arms: (1) isocaloric dietary intervention mainly based on plant-foods; (2) moderate-intensity PA intervention with at least 1 h/week of supervised strenuous activity; (3) both interventions; (4) general recommendations on healthy dietary and PA patterns. Interleukins (IL)-1α, -1β, -6, tumor necrosis factor-α and C-reactive protein were measured at baseline and at the end of the intervention. Intention-to-treat-analyses were carried out using Tobit regression. Although all cytokines tended to increase over time, after 24 months women in the PA intervention (arms 2 + 3) showed lower levels of IL-1α (exp(β) = 0.66; p = 0.04) and IL-6 (exp(β) = 0.70; p = 0.01) in comparison with women in the control group (arms 1 + 4). No effects of the dietary intervention emerged. In healthy postmenopausal women with high breast density a moderate-intensity PA appears to slow the age-related increase of pro-inflammatory cytokines.
format	article
author	G. Masala B. Bendinelli C. Della Bella M. Assedi S. Tapinassi I. Ermini D. Occhini M. Castaldo C. Saieva S. Caini M. M. D’Elios D. Palli
author_facet	G. Masala B. Bendinelli C. Della Bella M. Assedi S. Tapinassi I. Ermini D. Occhini M. Castaldo C. Saieva S. Caini M. M. D’Elios D. Palli
author_sort	G. Masala
title	Inflammatory marker changes in a 24-month dietary and physical activity randomised intervention trial in postmenopausal women
title_short	Inflammatory marker changes in a 24-month dietary and physical activity randomised intervention trial in postmenopausal women
title_full	Inflammatory marker changes in a 24-month dietary and physical activity randomised intervention trial in postmenopausal women
title_fullStr	Inflammatory marker changes in a 24-month dietary and physical activity randomised intervention trial in postmenopausal women
title_full_unstemmed	Inflammatory marker changes in a 24-month dietary and physical activity randomised intervention trial in postmenopausal women
title_sort	inflammatory marker changes in a 24-month dietary and physical activity randomised intervention trial in postmenopausal women
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/0803623bd2bb4935ad570f577eab43dd
work_keys_str_mv	AT gmasala inflammatorymarkerchangesina24monthdietaryandphysicalactivityrandomisedinterventiontrialinpostmenopausalwomen AT bbendinelli inflammatorymarkerchangesina24monthdietaryandphysicalactivityrandomisedinterventiontrialinpostmenopausalwomen AT cdellabella inflammatorymarkerchangesina24monthdietaryandphysicalactivityrandomisedinterventiontrialinpostmenopausalwomen AT massedi inflammatorymarkerchangesina24monthdietaryandphysicalactivityrandomisedinterventiontrialinpostmenopausalwomen AT stapinassi inflammatorymarkerchangesina24monthdietaryandphysicalactivityrandomisedinterventiontrialinpostmenopausalwomen AT iermini inflammatorymarkerchangesina24monthdietaryandphysicalactivityrandomisedinterventiontrialinpostmenopausalwomen AT docchini inflammatorymarkerchangesina24monthdietaryandphysicalactivityrandomisedinterventiontrialinpostmenopausalwomen AT mcastaldo inflammatorymarkerchangesina24monthdietaryandphysicalactivityrandomisedinterventiontrialinpostmenopausalwomen AT csaieva inflammatorymarkerchangesina24monthdietaryandphysicalactivityrandomisedinterventiontrialinpostmenopausalwomen AT scaini inflammatorymarkerchangesina24monthdietaryandphysicalactivityrandomisedinterventiontrialinpostmenopausalwomen AT mmdelios inflammatorymarkerchangesina24monthdietaryandphysicalactivityrandomisedinterventiontrialinpostmenopausalwomen AT dpalli inflammatorymarkerchangesina24monthdietaryandphysicalactivityrandomisedinterventiontrialinpostmenopausalwomen
_version_	1718393664039813120

Inflammatory marker changes in a 24-month dietary and physical activity randomised intervention trial in postmenopausal women

Ejemplares similares