The Gastroprotective Effect of Naringenin against Ethanol-Induced Gastric Ulcers in Mice through Inhibiting Oxidative and Inflammatory Responses

Naringenin is a major flavanone found in grapes, tangelos, blood oranges, lemons, pummelo, and tangerines. It is known to have anti-inflammatory, antioxidant, anticancer, antimutagenic, antifibrogenic, and antiatherogenic pharmacological properties. This study aims to investigate the anti-inflammato...

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Autores principales:	Wei-Sung Li, Shih-Chao Lin, Chien-Hui Chu, Yu-Kang Chang, Xiang Zhang, Chi-Chien Lin, Yu-Tang Tung
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	gastric ulcers naringenin ethanol inflammation oxidative stress Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/0803bd1bc2d7431789fd143a344f50c8
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spelling	oai:doaj.org-article:0803bd1bc2d7431789fd143a344f50c82021-11-11T17:24:20ZThe Gastroprotective Effect of Naringenin against Ethanol-Induced Gastric Ulcers in Mice through Inhibiting Oxidative and Inflammatory Responses10.3390/ijms2221119851422-00671661-6596https://doaj.org/article/0803bd1bc2d7431789fd143a344f50c82021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11985https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Naringenin is a major flavanone found in grapes, tangelos, blood oranges, lemons, pummelo, and tangerines. It is known to have anti-inflammatory, antioxidant, anticancer, antimutagenic, antifibrogenic, and antiatherogenic pharmacological properties. This study aims to investigate the anti-inflammatory effects of naringenin in ethanol-induced gastric damage in vivo and ethanol-stimulated KATO III cells in vitro. Our results showed that pretreatment with naringenin significantly protected mice from ethanol-induced hemorrhagic damage, epithelial cell loss, and edema with leucocytes. It reduced gastric ulcers (GU) by suppressing ethanol-induced nuclear factor-κB (NF-κB) activity and decreasing the levels of nitric oxide (NO), malondialdehyde (MDA), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-8 (IL-8), and myeloperoxidase (MPO). In addition, pretreatment with naringenin might inhibit the secretion of TNF-α, IL-6, and IL-8, as well as the proteins cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) via the suppression of NF-κB and mitogen-activated protein kinase (MAPK) signaling in ethanol-stimulated stomach epithelial KATO III cells. Together, the results of this study highlight the gastroprotective effect of naringenin in GU of mice by inhibiting gastric secretion and acidity, reducing inflammation and oxidative stress, suppressing NF-κB activity, and restoring the histological architecture. These findings suggested that naringenin has therapeutic potential in the alleviation of ethanol-induced GU.Wei-Sung LiShih-Chao LinChien-Hui ChuYu-Kang ChangXiang ZhangChi-Chien LinYu-Tang TungMDPI AGarticlegastric ulcersnaringeninethanolinflammationoxidative stressBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11985, p 11985 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	gastric ulcers naringenin ethanol inflammation oxidative stress Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	gastric ulcers naringenin ethanol inflammation oxidative stress Biology (General) QH301-705.5 Chemistry QD1-999 Wei-Sung Li Shih-Chao Lin Chien-Hui Chu Yu-Kang Chang Xiang Zhang Chi-Chien Lin Yu-Tang Tung The Gastroprotective Effect of Naringenin against Ethanol-Induced Gastric Ulcers in Mice through Inhibiting Oxidative and Inflammatory Responses
description	Naringenin is a major flavanone found in grapes, tangelos, blood oranges, lemons, pummelo, and tangerines. It is known to have anti-inflammatory, antioxidant, anticancer, antimutagenic, antifibrogenic, and antiatherogenic pharmacological properties. This study aims to investigate the anti-inflammatory effects of naringenin in ethanol-induced gastric damage in vivo and ethanol-stimulated KATO III cells in vitro. Our results showed that pretreatment with naringenin significantly protected mice from ethanol-induced hemorrhagic damage, epithelial cell loss, and edema with leucocytes. It reduced gastric ulcers (GU) by suppressing ethanol-induced nuclear factor-κB (NF-κB) activity and decreasing the levels of nitric oxide (NO), malondialdehyde (MDA), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-8 (IL-8), and myeloperoxidase (MPO). In addition, pretreatment with naringenin might inhibit the secretion of TNF-α, IL-6, and IL-8, as well as the proteins cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) via the suppression of NF-κB and mitogen-activated protein kinase (MAPK) signaling in ethanol-stimulated stomach epithelial KATO III cells. Together, the results of this study highlight the gastroprotective effect of naringenin in GU of mice by inhibiting gastric secretion and acidity, reducing inflammation and oxidative stress, suppressing NF-κB activity, and restoring the histological architecture. These findings suggested that naringenin has therapeutic potential in the alleviation of ethanol-induced GU.
format	article
author	Wei-Sung Li Shih-Chao Lin Chien-Hui Chu Yu-Kang Chang Xiang Zhang Chi-Chien Lin Yu-Tang Tung
author_facet	Wei-Sung Li Shih-Chao Lin Chien-Hui Chu Yu-Kang Chang Xiang Zhang Chi-Chien Lin Yu-Tang Tung
author_sort	Wei-Sung Li
title	The Gastroprotective Effect of Naringenin against Ethanol-Induced Gastric Ulcers in Mice through Inhibiting Oxidative and Inflammatory Responses
title_short	The Gastroprotective Effect of Naringenin against Ethanol-Induced Gastric Ulcers in Mice through Inhibiting Oxidative and Inflammatory Responses
title_full	The Gastroprotective Effect of Naringenin against Ethanol-Induced Gastric Ulcers in Mice through Inhibiting Oxidative and Inflammatory Responses
title_fullStr	The Gastroprotective Effect of Naringenin against Ethanol-Induced Gastric Ulcers in Mice through Inhibiting Oxidative and Inflammatory Responses
title_full_unstemmed	The Gastroprotective Effect of Naringenin against Ethanol-Induced Gastric Ulcers in Mice through Inhibiting Oxidative and Inflammatory Responses
title_sort	gastroprotective effect of naringenin against ethanol-induced gastric ulcers in mice through inhibiting oxidative and inflammatory responses
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/0803bd1bc2d7431789fd143a344f50c8
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The Gastroprotective Effect of Naringenin against Ethanol-Induced Gastric Ulcers in Mice through Inhibiting Oxidative and Inflammatory Responses

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