Inactivation and inducible oncogenic mutation of p53 in gene targeted pigs.

Inactivation and inducible oncogenic mutation of p53 in gene targeted pigs.

Mutation of the tumor suppressor p53 plays a major role in human carcinogenesis. Here we describe gene-targeted porcine mesenchymal stem cells (MSCs) and live pigs carrying a latent TP53(R167H) mutant allele, orthologous to oncogenic human mutant TP53(R175H) and mouse Trp53(R172H), that can be activ...

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Autores principales: Simon Leuchs, Anja Saalfrank, Claudia Merkl, Tatiana Flisikowska, Marlene Edlinger, Marina Durkovic, Nousin Rezaei, Mayuko Kurome, Valeri Zakhartchenko, Barbara Kessler, Krzysztof Flisikowski, Alexander Kind, Eckhard Wolf, Angelika Schnieke
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/0808a3ff409d4bf4a547bbad43b1616a
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