Aging of non-visual spectral sensitivity to light in humans: compensatory mechanisms?

The deterioration of sleep in the older population is a prevalent feature that contributes to a decrease in quality of life. Inappropriate entrainment of the circadian clock by light is considered to contribute to the alteration of sleep structure and circadian rhythms in the elderly. The present st...

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Autores principales:	Raymond P Najjar, Christophe Chiquet, Petteri Teikari, Pierre-Loïc Cornut, Bruno Claustrat, Philippe Denis, Howard M Cooper, Claude Gronfier
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/08095d11db8f421ebf1d6d443b837b24
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spelling	oai:doaj.org-article:08095d11db8f421ebf1d6d443b837b242021-11-18T08:36:14ZAging of non-visual spectral sensitivity to light in humans: compensatory mechanisms?1932-620310.1371/journal.pone.0085837https://doaj.org/article/08095d11db8f421ebf1d6d443b837b242014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24465738/?tool=EBIhttps://doaj.org/toc/1932-6203The deterioration of sleep in the older population is a prevalent feature that contributes to a decrease in quality of life. Inappropriate entrainment of the circadian clock by light is considered to contribute to the alteration of sleep structure and circadian rhythms in the elderly. The present study investigates the effects of aging on non-visual spectral sensitivity to light and tests the hypothesis that circadian disturbances are related to a decreased light transmittance. In a within-subject design, eight aged and five young subjects were exposed at night to 60 minute monochromatic light stimulations at 9 different wavelengths (420-620 nm). Individual sensitivity spectra were derived from measures of melatonin suppression. Lens density was assessed using a validated psychophysical technique. Although lens transmittance was decreased for short wavelength light in the older participants, melatonin suppression was not reduced. Peak of non-visual sensitivity was, however, shifted to longer wavelengths in the aged participants (494 nm) compared to young (484 nm). Our results indicate that increased lens filtering does not necessarily lead to a decreased non-visual sensitivity to light. The lack of age-related decrease in non-visual sensitivity to light may involve as yet undefined adaptive mechanisms.Raymond P NajjarChristophe ChiquetPetteri TeikariPierre-Loïc CornutBruno ClaustratPhilippe DenisHoward M CooperClaude GronfierPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 1, p e85837 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Raymond P Najjar Christophe Chiquet Petteri Teikari Pierre-Loïc Cornut Bruno Claustrat Philippe Denis Howard M Cooper Claude Gronfier Aging of non-visual spectral sensitivity to light in humans: compensatory mechanisms?
description	The deterioration of sleep in the older population is a prevalent feature that contributes to a decrease in quality of life. Inappropriate entrainment of the circadian clock by light is considered to contribute to the alteration of sleep structure and circadian rhythms in the elderly. The present study investigates the effects of aging on non-visual spectral sensitivity to light and tests the hypothesis that circadian disturbances are related to a decreased light transmittance. In a within-subject design, eight aged and five young subjects were exposed at night to 60 minute monochromatic light stimulations at 9 different wavelengths (420-620 nm). Individual sensitivity spectra were derived from measures of melatonin suppression. Lens density was assessed using a validated psychophysical technique. Although lens transmittance was decreased for short wavelength light in the older participants, melatonin suppression was not reduced. Peak of non-visual sensitivity was, however, shifted to longer wavelengths in the aged participants (494 nm) compared to young (484 nm). Our results indicate that increased lens filtering does not necessarily lead to a decreased non-visual sensitivity to light. The lack of age-related decrease in non-visual sensitivity to light may involve as yet undefined adaptive mechanisms.
format	article
author	Raymond P Najjar Christophe Chiquet Petteri Teikari Pierre-Loïc Cornut Bruno Claustrat Philippe Denis Howard M Cooper Claude Gronfier
author_facet	Raymond P Najjar Christophe Chiquet Petteri Teikari Pierre-Loïc Cornut Bruno Claustrat Philippe Denis Howard M Cooper Claude Gronfier
author_sort	Raymond P Najjar
title	Aging of non-visual spectral sensitivity to light in humans: compensatory mechanisms?
title_short	Aging of non-visual spectral sensitivity to light in humans: compensatory mechanisms?
title_full	Aging of non-visual spectral sensitivity to light in humans: compensatory mechanisms?
title_fullStr	Aging of non-visual spectral sensitivity to light in humans: compensatory mechanisms?
title_full_unstemmed	Aging of non-visual spectral sensitivity to light in humans: compensatory mechanisms?
title_sort	aging of non-visual spectral sensitivity to light in humans: compensatory mechanisms?
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/08095d11db8f421ebf1d6d443b837b24
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Aging of non-visual spectral sensitivity to light in humans: compensatory mechanisms?

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