Excitatory and inhibitory responses to cervical root magnetic stimulation in healthy subjects

Objectives: To characterize direct and reflex hand muscle responses to cervical root magnetic stimulation (CRMS) in healthy volunteers during sustained voluntary contraction. Methods: In 18 healthy volunteers, we recorded from the first dorsal interosseous (FDI) muscle the responses to CRMS of progr...

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Autores principales:	E. Ruiu, J. Valls-Sole
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Cervical root magnetic stimulation Mixed nerve stimulation Silent period Peristimulus time histogram Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/080a4430ae134bb994ad4863b5542c35
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spelling	oai:doaj.org-article:080a4430ae134bb994ad4863b5542c352021-11-18T04:50:53ZExcitatory and inhibitory responses to cervical root magnetic stimulation in healthy subjects2467-981X10.1016/j.cnp.2021.10.002https://doaj.org/article/080a4430ae134bb994ad4863b5542c352021-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2467981X21000445https://doaj.org/toc/2467-981XObjectives: To characterize direct and reflex hand muscle responses to cervical root magnetic stimulation (CRMS) in healthy volunteers during sustained voluntary contraction. Methods: In 18 healthy volunteers, we recorded from the first dorsal interosseous (FDI) muscle the responses to CRMS of progressively increasing intensity and level of muscle contraction. The compound muscle action potential (CMAP) and the silent period (SP) were compared to those obtained with plexus, midarm and wrist stimulation. Additionally, in a smaller number of subjects, we obtained the peristimulus time histogram (psth) of single motor unit firing in the FDI, examined the effects of vibration and recorded the modulation of sustained EMG activity in muscles of the lower limbs. Results: Increasing CRMS intensity led to larger CMAP with no relevant changes in SP1 or SP2, except for lower amplitude of the burst interrupting the silent period (BISP). Increasing the level of muscle contraction led to reduced CMAP, shorter SP duration and increased BISP amplitude. The psth analysis showed the underlying changes in the motor unit firing frequency that corresponded to the changes seen in the CMAP and the SP with surface recordings. Progressively distal stimulation led to CMAPs of shorter latency and increased amplitude, SPs of longer latency and shorter duration, and a BISP of longer latency. Vibration led to reduction of the SP. CRMS induced SPs in muscles of the lower limb. Conclusions: CRMS induces excitatory and inhibitory responses in hand muscles, fitting with the expected behavior of mixed nerve stimulation at very proximal sites. Significance: Characterization of the effects of CRMS on hand muscles is of physiological and potentially clinical applicability, as it is a painless and reliable procedure.E. RuiuJ. Valls-SoleElsevierarticleCervical root magnetic stimulationMixed nerve stimulationSilent periodPeristimulus time histogramNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENClinical Neurophysiology Practice, Vol 6, Iss , Pp 265-274 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cervical root magnetic stimulation Mixed nerve stimulation Silent period Peristimulus time histogram Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Cervical root magnetic stimulation Mixed nerve stimulation Silent period Peristimulus time histogram Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 E. Ruiu J. Valls-Sole Excitatory and inhibitory responses to cervical root magnetic stimulation in healthy subjects
description	Objectives: To characterize direct and reflex hand muscle responses to cervical root magnetic stimulation (CRMS) in healthy volunteers during sustained voluntary contraction. Methods: In 18 healthy volunteers, we recorded from the first dorsal interosseous (FDI) muscle the responses to CRMS of progressively increasing intensity and level of muscle contraction. The compound muscle action potential (CMAP) and the silent period (SP) were compared to those obtained with plexus, midarm and wrist stimulation. Additionally, in a smaller number of subjects, we obtained the peristimulus time histogram (psth) of single motor unit firing in the FDI, examined the effects of vibration and recorded the modulation of sustained EMG activity in muscles of the lower limbs. Results: Increasing CRMS intensity led to larger CMAP with no relevant changes in SP1 or SP2, except for lower amplitude of the burst interrupting the silent period (BISP). Increasing the level of muscle contraction led to reduced CMAP, shorter SP duration and increased BISP amplitude. The psth analysis showed the underlying changes in the motor unit firing frequency that corresponded to the changes seen in the CMAP and the SP with surface recordings. Progressively distal stimulation led to CMAPs of shorter latency and increased amplitude, SPs of longer latency and shorter duration, and a BISP of longer latency. Vibration led to reduction of the SP. CRMS induced SPs in muscles of the lower limb. Conclusions: CRMS induces excitatory and inhibitory responses in hand muscles, fitting with the expected behavior of mixed nerve stimulation at very proximal sites. Significance: Characterization of the effects of CRMS on hand muscles is of physiological and potentially clinical applicability, as it is a painless and reliable procedure.
format	article
author	E. Ruiu J. Valls-Sole
author_facet	E. Ruiu J. Valls-Sole
author_sort	E. Ruiu
title	Excitatory and inhibitory responses to cervical root magnetic stimulation in healthy subjects
title_short	Excitatory and inhibitory responses to cervical root magnetic stimulation in healthy subjects
title_full	Excitatory and inhibitory responses to cervical root magnetic stimulation in healthy subjects
title_fullStr	Excitatory and inhibitory responses to cervical root magnetic stimulation in healthy subjects
title_full_unstemmed	Excitatory and inhibitory responses to cervical root magnetic stimulation in healthy subjects
title_sort	excitatory and inhibitory responses to cervical root magnetic stimulation in healthy subjects
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/080a4430ae134bb994ad4863b5542c35
work_keys_str_mv	AT eruiu excitatoryandinhibitoryresponsestocervicalrootmagneticstimulationinhealthysubjects AT jvallssole excitatoryandinhibitoryresponsestocervicalrootmagneticstimulationinhealthysubjects
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Excitatory and inhibitory responses to cervical root magnetic stimulation in healthy subjects

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