Frequency-dependent neural activity in primary angle-closure glaucoma

Fei Jiang,1,* Chen Yu,2,* Min-Jing Zuo,1,* Chun Zhang,3 Ying Wang,4 Fu-Qing Zhou,2 Xian-Jun Zeng2 1Department of Radiology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, People’s Republic of China; 2Department of Radiology, The First Affiliated Hospital...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jiang F, Yu C, Zuo MJ, Zhang C, Wang Y, Zhou FQ, Zeng XJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	primary angle-closure glaucoma amplitude of low-frequency fluctuations frequency-dependent resting-state magnetic resonance imaging Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/080d8118ea0945739457b49d05a0917c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:080d8118ea0945739457b49d05a0917c
record_format	dspace
spelling	oai:doaj.org-article:080d8118ea0945739457b49d05a0917c2021-12-02T00:26:55ZFrequency-dependent neural activity in primary angle-closure glaucoma1178-2021https://doaj.org/article/080d8118ea0945739457b49d05a0917c2019-01-01T00:00:00Zhttps://www.dovepress.com/frequency-dependent-neural-activity-in-primary-angle-closure-glaucoma-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Fei Jiang,1,* Chen Yu,2,* Min-Jing Zuo,1,* Chun Zhang,3 Ying Wang,4 Fu-Qing Zhou,2 Xian-Jun Zeng2 1Department of Radiology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, People’s Republic of China; 2Department of Radiology, The First Affiliated Hospital of Nanchang University, Jiangxi Province Medical Imaging Research Institute, Nanchang, Jiangxi 330006, People’s Republic of China; 3Department of Radiology, Huai An Maternal and Child Health Hospital, Huai An, Jiangsu 223302, People’s Republic of China; 4Department of Ophthalmology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, People’s Republic of China *These authors contributed equally to this work Objective: In this study, we aimed to investigate the frequency-dependent spontaneous neural activity in primary angle-closure glaucoma (PACG) using the amplitude of low-frequency fluctuations (ALFF) method.Patients and methods: In total, 52 PACG individuals (24 males and 28 females) and 52 normal-sighted controls (NS; 24 males and 28 females) who were closely matched in age, sex, and education underwent resting-state magnetic resonance imaging scans. A repeated-measures ANOVA and post hoc two-sample t-tests were conducted to analyze the different ALFF values in two different frequency bands (slow-4, 0.027–0.073 Hz and slow-5, 0.010–0.027 Hz) between the two groups. Pearson’s correlation analysis was conducted to reveal the relationship between the mean ALFF values and clinical variables in the PACG group.Results: Compared to the NS group, the PACG group had high ALFF values in the right inferior occipital gyrus and low ALFF values in the left middle occipital gyrus, left precentral gyrus, and left postcentral gyrus in the slow-4 band. The PACG group had high ALFF values in the right inferior occipital gyrus and low ALFF values in the left inferior parietal lobule, left postcentral gyrus, and right precentral/postcentral gyrus in the slow-5 band. Specifically, we found that the abnormal ALFF values in the bilateral posterior cingulate gyrus and bilateral precuneus were higher in the slow-4 than in the slow-5 band, whereas ALFF in the bilateral frontal lobe, right fusiform, and right cerebellum posterior lobe were higher in the slow-5 than in the slow-4 band. The greater mean ALFF values of the right inferior occipital gyrus were associated with smaller retinal nerve fiber layer thickness and greater visual fields in PACG group in the slow-4 band.Conclusion: Our results highlighted that individuals in the PACG group showed abnormal spontaneous neural activities in the visual cortices, sensorimotor cortices, frontal lobe, frontoparietal network, and default mode network at two frequency bands, which might indicate impaired vision and cognition and emotion function in PACG individuals. These findings offer important insight into the understanding of the neural mechanism of PACG. Keywords: primary angle-closure glaucoma, amplitude of low-frequency fluctuations, frequency dependent, resting-state magnetic resonance imaging  Jiang FYu CZuo MJZhang CWang YZhou FQZeng XJDove Medical Pressarticleprimary angle-closure glaucomaamplitude of low-frequency fluctuationsfrequency-dependentresting-state magnetic resonance imagingNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 15, Pp 271-282 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	primary angle-closure glaucoma amplitude of low-frequency fluctuations frequency-dependent resting-state magnetic resonance imaging Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	primary angle-closure glaucoma amplitude of low-frequency fluctuations frequency-dependent resting-state magnetic resonance imaging Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Jiang F Yu C Zuo MJ Zhang C Wang Y Zhou FQ Zeng XJ Frequency-dependent neural activity in primary angle-closure glaucoma
description	Fei Jiang,1,* Chen Yu,2,* Min-Jing Zuo,1,* Chun Zhang,3 Ying Wang,4 Fu-Qing Zhou,2 Xian-Jun Zeng2 1Department of Radiology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, People’s Republic of China; 2Department of Radiology, The First Affiliated Hospital of Nanchang University, Jiangxi Province Medical Imaging Research Institute, Nanchang, Jiangxi 330006, People’s Republic of China; 3Department of Radiology, Huai An Maternal and Child Health Hospital, Huai An, Jiangsu 223302, People’s Republic of China; 4Department of Ophthalmology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, People’s Republic of China *These authors contributed equally to this work Objective: In this study, we aimed to investigate the frequency-dependent spontaneous neural activity in primary angle-closure glaucoma (PACG) using the amplitude of low-frequency fluctuations (ALFF) method.Patients and methods: In total, 52 PACG individuals (24 males and 28 females) and 52 normal-sighted controls (NS; 24 males and 28 females) who were closely matched in age, sex, and education underwent resting-state magnetic resonance imaging scans. A repeated-measures ANOVA and post hoc two-sample t-tests were conducted to analyze the different ALFF values in two different frequency bands (slow-4, 0.027–0.073 Hz and slow-5, 0.010–0.027 Hz) between the two groups. Pearson’s correlation analysis was conducted to reveal the relationship between the mean ALFF values and clinical variables in the PACG group.Results: Compared to the NS group, the PACG group had high ALFF values in the right inferior occipital gyrus and low ALFF values in the left middle occipital gyrus, left precentral gyrus, and left postcentral gyrus in the slow-4 band. The PACG group had high ALFF values in the right inferior occipital gyrus and low ALFF values in the left inferior parietal lobule, left postcentral gyrus, and right precentral/postcentral gyrus in the slow-5 band. Specifically, we found that the abnormal ALFF values in the bilateral posterior cingulate gyrus and bilateral precuneus were higher in the slow-4 than in the slow-5 band, whereas ALFF in the bilateral frontal lobe, right fusiform, and right cerebellum posterior lobe were higher in the slow-5 than in the slow-4 band. The greater mean ALFF values of the right inferior occipital gyrus were associated with smaller retinal nerve fiber layer thickness and greater visual fields in PACG group in the slow-4 band.Conclusion: Our results highlighted that individuals in the PACG group showed abnormal spontaneous neural activities in the visual cortices, sensorimotor cortices, frontal lobe, frontoparietal network, and default mode network at two frequency bands, which might indicate impaired vision and cognition and emotion function in PACG individuals. These findings offer important insight into the understanding of the neural mechanism of PACG. Keywords: primary angle-closure glaucoma, amplitude of low-frequency fluctuations, frequency dependent, resting-state magnetic resonance imaging
format	article
author	Jiang F Yu C Zuo MJ Zhang C Wang Y Zhou FQ Zeng XJ
author_facet	Jiang F Yu C Zuo MJ Zhang C Wang Y Zhou FQ Zeng XJ
author_sort	Jiang F
title	Frequency-dependent neural activity in primary angle-closure glaucoma
title_short	Frequency-dependent neural activity in primary angle-closure glaucoma
title_full	Frequency-dependent neural activity in primary angle-closure glaucoma
title_fullStr	Frequency-dependent neural activity in primary angle-closure glaucoma
title_full_unstemmed	Frequency-dependent neural activity in primary angle-closure glaucoma
title_sort	frequency-dependent neural activity in primary angle-closure glaucoma
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/080d8118ea0945739457b49d05a0917c
work_keys_str_mv	AT jiangf frequencydependentneuralactivityinprimaryangleclosureglaucoma AT yuc frequencydependentneuralactivityinprimaryangleclosureglaucoma AT zuomj frequencydependentneuralactivityinprimaryangleclosureglaucoma AT zhangc frequencydependentneuralactivityinprimaryangleclosureglaucoma AT wangy frequencydependentneuralactivityinprimaryangleclosureglaucoma AT zhoufq frequencydependentneuralactivityinprimaryangleclosureglaucoma AT zengxj frequencydependentneuralactivityinprimaryangleclosureglaucoma
_version_	1718403720251703296

Frequency-dependent neural activity in primary angle-closure glaucoma

Ejemplares similares