Autonomic Symptoms in Older Adults Are Common and Associated With Health-Related Quality of Life

Background: Autonomic symptoms are common in older adults, and a large body of literature focusing on age-related diseases shows that autonomic symptoms in these diseases constrain Health-Related Quality of Life (HRQoL). To our best knowledge, the association between autonomic symptoms in older adul...

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Autores principales:	Sarah Renno-Busch, Hanna Hildesheim, Janet M. T. van Uem, Ulrike Sünkel, Benjamin Röben, Kathrin Brockmann, Christian Mychajliw, Gerhard W. Eschweiler, Daniela Berg, Walter Maetzler
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	autonomic symptoms Composite autonomic symptom score 31 (COMPASS 31) health-related quality of life older adults TREND study Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/0810727bbef54e7ba5e2636de3f9122a
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spelling	oai:doaj.org-article:0810727bbef54e7ba5e2636de3f9122a2021-11-30T12:29:42ZAutonomic Symptoms in Older Adults Are Common and Associated With Health-Related Quality of Life1664-229510.3389/fneur.2021.757748https://doaj.org/article/0810727bbef54e7ba5e2636de3f9122a2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fneur.2021.757748/fullhttps://doaj.org/toc/1664-2295Background: Autonomic symptoms are common in older adults, and a large body of literature focusing on age-related diseases shows that autonomic symptoms in these diseases constrain Health-Related Quality of Life (HRQoL). To our best knowledge, the association between autonomic symptoms in older adults, independent of specific diseases, and HRQoL has not yet been assessed.Aim: To assess the frequency and the effect of autonomic symptoms in general, as well as orthostatic intolerance, vasomotor, secretomotor, gastrointestinal, bladder, and pupillomotor symptoms, on HRQoL in older adults.Methods: Cross-sectional data of the fourth visit of the Tübinger evaluation of Risk factors for Early detection of Neurodegeneration (TREND) study were included. Autonomic symptoms, as assessed with the Composite Autonomic Symptom Score 31 (COMPASS 31), were quantified and compared with HRQoL, as assessed with the EuroQol five-level version (EQ-5D-5L). Statistical analyses included Spearman's rank correlation and multiple linear regression analysis.Results: The analysis included 928 participants with a median of 68 years; 47% were women. Of those, 85% reported at least one autonomic symptom. Gastrointestinal and secretomotor symptoms were most common. The COMPASS 31 total score and all subdomains were significantly associated with reduced HRQoL. Among the subdomains, the strongest correlations with HRQoL were found for gastrointestinal and bladder symptoms. Overall, autonomic symptoms alone explained 20% of the variance of HRQoL; when depressive mood was added, the model explained 32%.Conclusion: Autonomic symptoms are associated with HRQoL and depressive symptoms in older adults.Sarah Renno-BuschHanna HildesheimJanet M. T. van UemUlrike SünkelBenjamin RöbenKathrin BrockmannChristian MychajliwGerhard W. EschweilerDaniela BergDaniela BergWalter MaetzlerWalter MaetzlerFrontiers Media S.A.articleautonomic symptomsComposite autonomic symptom score 31 (COMPASS 31)health-related quality of lifeolder adultsTREND studyNeurology. Diseases of the nervous systemRC346-429ENFrontiers in Neurology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	autonomic symptoms Composite autonomic symptom score 31 (COMPASS 31) health-related quality of life older adults TREND study Neurology. Diseases of the nervous system RC346-429
spellingShingle	autonomic symptoms Composite autonomic symptom score 31 (COMPASS 31) health-related quality of life older adults TREND study Neurology. Diseases of the nervous system RC346-429 Sarah Renno-Busch Hanna Hildesheim Janet M. T. van Uem Ulrike Sünkel Benjamin Röben Kathrin Brockmann Christian Mychajliw Gerhard W. Eschweiler Daniela Berg Daniela Berg Walter Maetzler Walter Maetzler Autonomic Symptoms in Older Adults Are Common and Associated With Health-Related Quality of Life
description	Background: Autonomic symptoms are common in older adults, and a large body of literature focusing on age-related diseases shows that autonomic symptoms in these diseases constrain Health-Related Quality of Life (HRQoL). To our best knowledge, the association between autonomic symptoms in older adults, independent of specific diseases, and HRQoL has not yet been assessed.Aim: To assess the frequency and the effect of autonomic symptoms in general, as well as orthostatic intolerance, vasomotor, secretomotor, gastrointestinal, bladder, and pupillomotor symptoms, on HRQoL in older adults.Methods: Cross-sectional data of the fourth visit of the Tübinger evaluation of Risk factors for Early detection of Neurodegeneration (TREND) study were included. Autonomic symptoms, as assessed with the Composite Autonomic Symptom Score 31 (COMPASS 31), were quantified and compared with HRQoL, as assessed with the EuroQol five-level version (EQ-5D-5L). Statistical analyses included Spearman's rank correlation and multiple linear regression analysis.Results: The analysis included 928 participants with a median of 68 years; 47% were women. Of those, 85% reported at least one autonomic symptom. Gastrointestinal and secretomotor symptoms were most common. The COMPASS 31 total score and all subdomains were significantly associated with reduced HRQoL. Among the subdomains, the strongest correlations with HRQoL were found for gastrointestinal and bladder symptoms. Overall, autonomic symptoms alone explained 20% of the variance of HRQoL; when depressive mood was added, the model explained 32%.Conclusion: Autonomic symptoms are associated with HRQoL and depressive symptoms in older adults.
format	article
author	Sarah Renno-Busch Hanna Hildesheim Janet M. T. van Uem Ulrike Sünkel Benjamin Röben Kathrin Brockmann Christian Mychajliw Gerhard W. Eschweiler Daniela Berg Daniela Berg Walter Maetzler Walter Maetzler
author_facet	Sarah Renno-Busch Hanna Hildesheim Janet M. T. van Uem Ulrike Sünkel Benjamin Röben Kathrin Brockmann Christian Mychajliw Gerhard W. Eschweiler Daniela Berg Daniela Berg Walter Maetzler Walter Maetzler
author_sort	Sarah Renno-Busch
title	Autonomic Symptoms in Older Adults Are Common and Associated With Health-Related Quality of Life
title_short	Autonomic Symptoms in Older Adults Are Common and Associated With Health-Related Quality of Life
title_full	Autonomic Symptoms in Older Adults Are Common and Associated With Health-Related Quality of Life
title_fullStr	Autonomic Symptoms in Older Adults Are Common and Associated With Health-Related Quality of Life
title_full_unstemmed	Autonomic Symptoms in Older Adults Are Common and Associated With Health-Related Quality of Life
title_sort	autonomic symptoms in older adults are common and associated with health-related quality of life
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/0810727bbef54e7ba5e2636de3f9122a
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Autonomic Symptoms in Older Adults Are Common and Associated With Health-Related Quality of Life

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