The potential role of curcumin (diferuloylmethane) in plasma cell dyscrasias/paraproteinemia
Terry Golombick, Terry DiamondDepartment of Endocrinology, St George Hospital, Kogarah, AustraliaAbstract: Plasma cell dyscrasias, most commonly associated with paraproteinemia, are a diverse group of diseases. Monoclonal gammopathy of undefined significance (MGUS) can precede multiple myeloma, a pr...
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Dove Medical Press
2008
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oai:doaj.org-article:0814732a76e2415f9917f09397acc14f2021-12-02T08:36:33ZThe potential role of curcumin (diferuloylmethane) in plasma cell dyscrasias/paraproteinemia1177-54751177-5491https://doaj.org/article/0814732a76e2415f9917f09397acc14f2008-03-01T00:00:00Zhttp://www.dovepress.com/the-potential-role-of-curcumin-diferuloylmethane-in-plasma-cell-dyscra-a65https://doaj.org/toc/1177-5475https://doaj.org/toc/1177-5491Terry Golombick, Terry DiamondDepartment of Endocrinology, St George Hospital, Kogarah, AustraliaAbstract: Plasma cell dyscrasias, most commonly associated with paraproteinemia, are a diverse group of diseases. Monoclonal gammopathy of undefined significance (MGUS) can precede multiple myeloma, a progressive neoplastic disease. MGUS occurs in association with a variety of other diseases and currently no treatment is recommended but rather “watchful waiting”. Given that the size of the M-protein is a risk factor for disease progression, early intervention with the aim of reducing the paraprotein load would provide an innovative therapeutic tool. Preliminary results from our pilot study show a drop of between 5% and 30% serum paraprotein in patients taking curcumin compared with patients on placebo. Curcumin is a diferuloylmethane present in extracts of the rhizome of the Curcuma longa plant. As a natural product, this has exciting potential in the treatment of plasma cell dyscrasias.Keywords: plasma cell dyscrasias, MGUS, myeloma, curcumin, paraproteinemia Terry GolombickTerry DiamondDove Medical PressarticleMedicine (General)R5-920ENBiologics: Targets & Therapy, Vol 2008, Iss Issue 1, Pp 161-163 (2008) |
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Medicine (General) R5-920 |
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Medicine (General) R5-920 Terry Golombick Terry Diamond The potential role of curcumin (diferuloylmethane) in plasma cell dyscrasias/paraproteinemia |
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Terry Golombick, Terry DiamondDepartment of Endocrinology, St George Hospital, Kogarah, AustraliaAbstract: Plasma cell dyscrasias, most commonly associated with paraproteinemia, are a diverse group of diseases. Monoclonal gammopathy of undefined significance (MGUS) can precede multiple myeloma, a progressive neoplastic disease. MGUS occurs in association with a variety of other diseases and currently no treatment is recommended but rather “watchful waiting”. Given that the size of the M-protein is a risk factor for disease progression, early intervention with the aim of reducing the paraprotein load would provide an innovative therapeutic tool. Preliminary results from our pilot study show a drop of between 5% and 30% serum paraprotein in patients taking curcumin compared with patients on placebo. Curcumin is a diferuloylmethane present in extracts of the rhizome of the Curcuma longa plant. As a natural product, this has exciting potential in the treatment of plasma cell dyscrasias.Keywords: plasma cell dyscrasias, MGUS, myeloma, curcumin, paraproteinemia |
| format |
article |
| author |
Terry Golombick Terry Diamond |
| author_facet |
Terry Golombick Terry Diamond |
| author_sort |
Terry Golombick |
| title |
The potential role of curcumin (diferuloylmethane) in plasma cell dyscrasias/paraproteinemia |
| title_short |
The potential role of curcumin (diferuloylmethane) in plasma cell dyscrasias/paraproteinemia |
| title_full |
The potential role of curcumin (diferuloylmethane) in plasma cell dyscrasias/paraproteinemia |
| title_fullStr |
The potential role of curcumin (diferuloylmethane) in plasma cell dyscrasias/paraproteinemia |
| title_full_unstemmed |
The potential role of curcumin (diferuloylmethane) in plasma cell dyscrasias/paraproteinemia |
| title_sort |
potential role of curcumin (diferuloylmethane) in plasma cell dyscrasias/paraproteinemia |
| publisher |
Dove Medical Press |
| publishDate |
2008 |
| url |
https://doaj.org/article/0814732a76e2415f9917f09397acc14f |
| work_keys_str_mv |
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