Metabolomics-based analysis of miniature flask contents identifies tobacco mixture use among the ancient Maya

Abstract A particular type of miniature ceramic vessel locally known as “veneneras” is occasionally found during archaeological excavations in the Maya Area. To date, only one study of a collection of such containers successfully identified organic residues through coupled chromatography–mass spectr...

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Autores principales:	Mario Zimmermann, Korey J. Brownstein, Luis Pantoja Díaz, Iliana Ancona Aragón, Scott Hutson, Barry Kidder, Shannon Tushingham, David R. Gang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/08148e7984a9467a83b6a2b50449c658
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spelling	oai:doaj.org-article:08148e7984a9467a83b6a2b50449c6582021-12-02T14:01:32ZMetabolomics-based analysis of miniature flask contents identifies tobacco mixture use among the ancient Maya10.1038/s41598-021-81158-y2045-2322https://doaj.org/article/08148e7984a9467a83b6a2b50449c6582021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81158-yhttps://doaj.org/toc/2045-2322Abstract A particular type of miniature ceramic vessel locally known as “veneneras” is occasionally found during archaeological excavations in the Maya Area. To date, only one study of a collection of such containers successfully identified organic residues through coupled chromatography–mass spectrometry methods. That study identified traces of nicotine likely associated with tobacco. Here we present a more complete picture by analyzing a suite of possible complementary ingredients in tobacco mixtures across a collection of 14 miniature vessels. The collection includes four different vessel forms and allows for the comparison of specimens which had previously formed part of museum exhibitions with recently excavated, untreated containers. Archaeological samples were compared with fresh as well as cured reference materials from two different species of tobacco (Nicotiana tabacum and N. rustica). In addition, we sampled six more plants which are linked to mind-altering practices through Mesoamerican ethnohistoric or ethnographic records. Analyses were conducted using UPLC-MS metabolomics-based analytical techniques, which significantly expand the possible detection of chemical compounds compared to previous biomarker-focused studies. Results include the detection of more than 9000 residual chemical features. We trace, for the first time, the presence of Mexican marigold (Tagetes lucida) in presumptive polydrug mixtures.Mario ZimmermannKorey J. BrownsteinLuis Pantoja DíazIliana Ancona AragónScott HutsonBarry KidderShannon TushinghamDavid R. GangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mario Zimmermann Korey J. Brownstein Luis Pantoja Díaz Iliana Ancona Aragón Scott Hutson Barry Kidder Shannon Tushingham David R. Gang Metabolomics-based analysis of miniature flask contents identifies tobacco mixture use among the ancient Maya
description	Abstract A particular type of miniature ceramic vessel locally known as “veneneras” is occasionally found during archaeological excavations in the Maya Area. To date, only one study of a collection of such containers successfully identified organic residues through coupled chromatography–mass spectrometry methods. That study identified traces of nicotine likely associated with tobacco. Here we present a more complete picture by analyzing a suite of possible complementary ingredients in tobacco mixtures across a collection of 14 miniature vessels. The collection includes four different vessel forms and allows for the comparison of specimens which had previously formed part of museum exhibitions with recently excavated, untreated containers. Archaeological samples were compared with fresh as well as cured reference materials from two different species of tobacco (Nicotiana tabacum and N. rustica). In addition, we sampled six more plants which are linked to mind-altering practices through Mesoamerican ethnohistoric or ethnographic records. Analyses were conducted using UPLC-MS metabolomics-based analytical techniques, which significantly expand the possible detection of chemical compounds compared to previous biomarker-focused studies. Results include the detection of more than 9000 residual chemical features. We trace, for the first time, the presence of Mexican marigold (Tagetes lucida) in presumptive polydrug mixtures.
format	article
author	Mario Zimmermann Korey J. Brownstein Luis Pantoja Díaz Iliana Ancona Aragón Scott Hutson Barry Kidder Shannon Tushingham David R. Gang
author_facet	Mario Zimmermann Korey J. Brownstein Luis Pantoja Díaz Iliana Ancona Aragón Scott Hutson Barry Kidder Shannon Tushingham David R. Gang
author_sort	Mario Zimmermann
title	Metabolomics-based analysis of miniature flask contents identifies tobacco mixture use among the ancient Maya
title_short	Metabolomics-based analysis of miniature flask contents identifies tobacco mixture use among the ancient Maya
title_full	Metabolomics-based analysis of miniature flask contents identifies tobacco mixture use among the ancient Maya
title_fullStr	Metabolomics-based analysis of miniature flask contents identifies tobacco mixture use among the ancient Maya
title_full_unstemmed	Metabolomics-based analysis of miniature flask contents identifies tobacco mixture use among the ancient Maya
title_sort	metabolomics-based analysis of miniature flask contents identifies tobacco mixture use among the ancient maya
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/08148e7984a9467a83b6a2b50449c658
work_keys_str_mv	AT mariozimmermann metabolomicsbasedanalysisofminiatureflaskcontentsidentifiestobaccomixtureuseamongtheancientmaya AT koreyjbrownstein metabolomicsbasedanalysisofminiatureflaskcontentsidentifiestobaccomixtureuseamongtheancientmaya AT luispantojadiaz metabolomicsbasedanalysisofminiatureflaskcontentsidentifiestobaccomixtureuseamongtheancientmaya AT ilianaanconaaragon metabolomicsbasedanalysisofminiatureflaskcontentsidentifiestobaccomixtureuseamongtheancientmaya AT scotthutson metabolomicsbasedanalysisofminiatureflaskcontentsidentifiestobaccomixtureuseamongtheancientmaya AT barrykidder metabolomicsbasedanalysisofminiatureflaskcontentsidentifiestobaccomixtureuseamongtheancientmaya AT shannontushingham metabolomicsbasedanalysisofminiatureflaskcontentsidentifiestobaccomixtureuseamongtheancientmaya AT davidrgang metabolomicsbasedanalysisofminiatureflaskcontentsidentifiestobaccomixtureuseamongtheancientmaya
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Metabolomics-based analysis of miniature flask contents identifies tobacco mixture use among the ancient Maya

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