Immunogenicity of a DNA vaccine candidate for COVID-19
There is currently no licensed SARS-CoV-2 vaccine. Here, the authors generate an optimized DNA vaccine candidate encoding the SARS-CoV-2 spike antigen, demonstrating induction of specific T cells and neutralizing antibody responses in mice and guinea pigs. These initial results support further devel...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2020
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/0814bda6deff4859a14eda518fea5941 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:0814bda6deff4859a14eda518fea5941 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:0814bda6deff4859a14eda518fea59412021-12-02T15:53:08ZImmunogenicity of a DNA vaccine candidate for COVID-1910.1038/s41467-020-16505-02041-1723https://doaj.org/article/0814bda6deff4859a14eda518fea59412020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16505-0https://doaj.org/toc/2041-1723There is currently no licensed SARS-CoV-2 vaccine. Here, the authors generate an optimized DNA vaccine candidate encoding the SARS-CoV-2 spike antigen, demonstrating induction of specific T cells and neutralizing antibody responses in mice and guinea pigs. These initial results support further development of this vaccine candidate.Trevor R. F. SmithAmi PatelStephanie RamosDustin ElwoodXizhou ZhuJian YanEbony N. GarySusanne N. WalkerKatherine SchultheisMansi PurwarZiyang XuJewell WaltersPratik BhojnagarwalaMaria YangNeethu ChokkalingamPatrick PezzoliElizabeth ParzychEmma L. ReuschelArthur DoanNicholas TursiMiguel VasquezJihae ChoiEdgar Tello-RuizIgor MaricicMamadou A. BahYuanhan WuDinah AmanteDaniel H. ParkYaya DiaAli Raza AliFaraz I. ZaidiAlison GenerottiKevin Y. KimTimothy A. HerringSophia ReederViviane M. AndradeKaren ButtigiegGan ZhaoJiun-Ming WuDan LiLinlin BaoJiangning LiuWei DengChuan QinAmi Shah BrownMakan KhoshnejadNianshuang WangJacqueline ChuDaniel WrappJason S. McLellanKar MuthumaniBin WangMiles W. CarrollJ. Joseph KimJean BoyerDaniel W. KulpLaurent M. P. F. HumeauDavid B. WeinerKate E. BroderickNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Trevor R. F. Smith Ami Patel Stephanie Ramos Dustin Elwood Xizhou Zhu Jian Yan Ebony N. Gary Susanne N. Walker Katherine Schultheis Mansi Purwar Ziyang Xu Jewell Walters Pratik Bhojnagarwala Maria Yang Neethu Chokkalingam Patrick Pezzoli Elizabeth Parzych Emma L. Reuschel Arthur Doan Nicholas Tursi Miguel Vasquez Jihae Choi Edgar Tello-Ruiz Igor Maricic Mamadou A. Bah Yuanhan Wu Dinah Amante Daniel H. Park Yaya Dia Ali Raza Ali Faraz I. Zaidi Alison Generotti Kevin Y. Kim Timothy A. Herring Sophia Reeder Viviane M. Andrade Karen Buttigieg Gan Zhao Jiun-Ming Wu Dan Li Linlin Bao Jiangning Liu Wei Deng Chuan Qin Ami Shah Brown Makan Khoshnejad Nianshuang Wang Jacqueline Chu Daniel Wrapp Jason S. McLellan Kar Muthumani Bin Wang Miles W. Carroll J. Joseph Kim Jean Boyer Daniel W. Kulp Laurent M. P. F. Humeau David B. Weiner Kate E. Broderick Immunogenicity of a DNA vaccine candidate for COVID-19 |
| description |
There is currently no licensed SARS-CoV-2 vaccine. Here, the authors generate an optimized DNA vaccine candidate encoding the SARS-CoV-2 spike antigen, demonstrating induction of specific T cells and neutralizing antibody responses in mice and guinea pigs. These initial results support further development of this vaccine candidate. |
| format |
article |
| author |
Trevor R. F. Smith Ami Patel Stephanie Ramos Dustin Elwood Xizhou Zhu Jian Yan Ebony N. Gary Susanne N. Walker Katherine Schultheis Mansi Purwar Ziyang Xu Jewell Walters Pratik Bhojnagarwala Maria Yang Neethu Chokkalingam Patrick Pezzoli Elizabeth Parzych Emma L. Reuschel Arthur Doan Nicholas Tursi Miguel Vasquez Jihae Choi Edgar Tello-Ruiz Igor Maricic Mamadou A. Bah Yuanhan Wu Dinah Amante Daniel H. Park Yaya Dia Ali Raza Ali Faraz I. Zaidi Alison Generotti Kevin Y. Kim Timothy A. Herring Sophia Reeder Viviane M. Andrade Karen Buttigieg Gan Zhao Jiun-Ming Wu Dan Li Linlin Bao Jiangning Liu Wei Deng Chuan Qin Ami Shah Brown Makan Khoshnejad Nianshuang Wang Jacqueline Chu Daniel Wrapp Jason S. McLellan Kar Muthumani Bin Wang Miles W. Carroll J. Joseph Kim Jean Boyer Daniel W. Kulp Laurent M. P. F. Humeau David B. Weiner Kate E. Broderick |
| author_facet |
Trevor R. F. Smith Ami Patel Stephanie Ramos Dustin Elwood Xizhou Zhu Jian Yan Ebony N. Gary Susanne N. Walker Katherine Schultheis Mansi Purwar Ziyang Xu Jewell Walters Pratik Bhojnagarwala Maria Yang Neethu Chokkalingam Patrick Pezzoli Elizabeth Parzych Emma L. Reuschel Arthur Doan Nicholas Tursi Miguel Vasquez Jihae Choi Edgar Tello-Ruiz Igor Maricic Mamadou A. Bah Yuanhan Wu Dinah Amante Daniel H. Park Yaya Dia Ali Raza Ali Faraz I. Zaidi Alison Generotti Kevin Y. Kim Timothy A. Herring Sophia Reeder Viviane M. Andrade Karen Buttigieg Gan Zhao Jiun-Ming Wu Dan Li Linlin Bao Jiangning Liu Wei Deng Chuan Qin Ami Shah Brown Makan Khoshnejad Nianshuang Wang Jacqueline Chu Daniel Wrapp Jason S. McLellan Kar Muthumani Bin Wang Miles W. Carroll J. Joseph Kim Jean Boyer Daniel W. Kulp Laurent M. P. F. Humeau David B. Weiner Kate E. Broderick |
| author_sort |
Trevor R. F. Smith |
| title |
Immunogenicity of a DNA vaccine candidate for COVID-19 |
| title_short |
Immunogenicity of a DNA vaccine candidate for COVID-19 |
| title_full |
Immunogenicity of a DNA vaccine candidate for COVID-19 |
| title_fullStr |
Immunogenicity of a DNA vaccine candidate for COVID-19 |
| title_full_unstemmed |
Immunogenicity of a DNA vaccine candidate for COVID-19 |
| title_sort |
immunogenicity of a dna vaccine candidate for covid-19 |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/0814bda6deff4859a14eda518fea5941 |
| work_keys_str_mv |
AT trevorrfsmith immunogenicityofadnavaccinecandidateforcovid19 AT amipatel immunogenicityofadnavaccinecandidateforcovid19 AT stephanieramos immunogenicityofadnavaccinecandidateforcovid19 AT dustinelwood immunogenicityofadnavaccinecandidateforcovid19 AT xizhouzhu immunogenicityofadnavaccinecandidateforcovid19 AT jianyan immunogenicityofadnavaccinecandidateforcovid19 AT ebonyngary immunogenicityofadnavaccinecandidateforcovid19 AT susannenwalker immunogenicityofadnavaccinecandidateforcovid19 AT katherineschultheis immunogenicityofadnavaccinecandidateforcovid19 AT mansipurwar immunogenicityofadnavaccinecandidateforcovid19 AT ziyangxu immunogenicityofadnavaccinecandidateforcovid19 AT jewellwalters immunogenicityofadnavaccinecandidateforcovid19 AT pratikbhojnagarwala immunogenicityofadnavaccinecandidateforcovid19 AT mariayang immunogenicityofadnavaccinecandidateforcovid19 AT neethuchokkalingam immunogenicityofadnavaccinecandidateforcovid19 AT patrickpezzoli immunogenicityofadnavaccinecandidateforcovid19 AT elizabethparzych immunogenicityofadnavaccinecandidateforcovid19 AT emmalreuschel immunogenicityofadnavaccinecandidateforcovid19 AT arthurdoan immunogenicityofadnavaccinecandidateforcovid19 AT nicholastursi immunogenicityofadnavaccinecandidateforcovid19 AT miguelvasquez immunogenicityofadnavaccinecandidateforcovid19 AT jihaechoi immunogenicityofadnavaccinecandidateforcovid19 AT edgartelloruiz immunogenicityofadnavaccinecandidateforcovid19 AT igormaricic immunogenicityofadnavaccinecandidateforcovid19 AT mamadouabah immunogenicityofadnavaccinecandidateforcovid19 AT yuanhanwu immunogenicityofadnavaccinecandidateforcovid19 AT dinahamante immunogenicityofadnavaccinecandidateforcovid19 AT danielhpark immunogenicityofadnavaccinecandidateforcovid19 AT yayadia immunogenicityofadnavaccinecandidateforcovid19 AT alirazaali immunogenicityofadnavaccinecandidateforcovid19 AT farazizaidi immunogenicityofadnavaccinecandidateforcovid19 AT alisongenerotti immunogenicityofadnavaccinecandidateforcovid19 AT kevinykim immunogenicityofadnavaccinecandidateforcovid19 AT timothyaherring immunogenicityofadnavaccinecandidateforcovid19 AT sophiareeder immunogenicityofadnavaccinecandidateforcovid19 AT vivianemandrade immunogenicityofadnavaccinecandidateforcovid19 AT karenbuttigieg immunogenicityofadnavaccinecandidateforcovid19 AT ganzhao immunogenicityofadnavaccinecandidateforcovid19 AT jiunmingwu immunogenicityofadnavaccinecandidateforcovid19 AT danli immunogenicityofadnavaccinecandidateforcovid19 AT linlinbao immunogenicityofadnavaccinecandidateforcovid19 AT jiangningliu immunogenicityofadnavaccinecandidateforcovid19 AT weideng immunogenicityofadnavaccinecandidateforcovid19 AT chuanqin immunogenicityofadnavaccinecandidateforcovid19 AT amishahbrown immunogenicityofadnavaccinecandidateforcovid19 AT makankhoshnejad immunogenicityofadnavaccinecandidateforcovid19 AT nianshuangwang immunogenicityofadnavaccinecandidateforcovid19 AT jacquelinechu immunogenicityofadnavaccinecandidateforcovid19 AT danielwrapp immunogenicityofadnavaccinecandidateforcovid19 AT jasonsmclellan immunogenicityofadnavaccinecandidateforcovid19 AT karmuthumani immunogenicityofadnavaccinecandidateforcovid19 AT binwang immunogenicityofadnavaccinecandidateforcovid19 AT mileswcarroll immunogenicityofadnavaccinecandidateforcovid19 AT jjosephkim immunogenicityofadnavaccinecandidateforcovid19 AT jeanboyer immunogenicityofadnavaccinecandidateforcovid19 AT danielwkulp immunogenicityofadnavaccinecandidateforcovid19 AT laurentmpfhumeau immunogenicityofadnavaccinecandidateforcovid19 AT davidbweiner immunogenicityofadnavaccinecandidateforcovid19 AT kateebroderick immunogenicityofadnavaccinecandidateforcovid19 |
| _version_ |
1718385492515356672 |