Epidemiology of Bleeding in Critically Ill Children With an Underlying Oncologic Diagnosis
OBJECTIVES:. Critically ill children with malignancy have significant risk of bleeding but the exact epidemiology is unknown. We sought to describe severe bleeding events and associated risk factors in critically ill pediatric patients with an underlying oncologic diagnosis using the newly developed...
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Wolters Kluwer
2021
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oai:doaj.org-article:081ba4f6cca3476a87048ae75fc0f5922021-11-25T07:56:59ZEpidemiology of Bleeding in Critically Ill Children With an Underlying Oncologic Diagnosis2639-802810.1097/CCE.0000000000000572https://doaj.org/article/081ba4f6cca3476a87048ae75fc0f5922021-11-01T00:00:00Zhttp://journals.lww.com/10.1097/CCE.0000000000000572https://doaj.org/toc/2639-8028OBJECTIVES:. Critically ill children with malignancy have significant risk of bleeding but the exact epidemiology is unknown. We sought to describe severe bleeding events and associated risk factors in critically ill pediatric patients with an underlying oncologic diagnosis using the newly developed Bleeding Assessment Scale in Critically Ill Children definition. DESIGN:. Retrospective cohort study. SETTING:. PICU in comprehensive cancer center, PATIENTS:. Children ages 28 days to 18 years with an underlying oncologic diagnosis admitted to the PICU during 2018. INTERVENTIONS:. None. MEASUREMENTS AND MAIN RESULTS:. Two-hundred sixty-seven admissions met inclusion criteria. Sixty-four percent (171/267) were male, with a median (interquartile range) age of 6.3 years (3.1–12.1 yr). Nine percent (23/267) had at least one severe bleeding event during their PICU admission. There were no significant differences between those with severe bleeding and those without, with respect to gender (p = 0.07), age (p = 0.66), weight (p = 0.76), or transplant status (p = 0.18). There was a difference in the frequency of severe bleeding based on underlying oncologic diagnosis (p = 0.009). For patients with severe bleeding, the median (interquartile range) platelet count and international normalized ratio on the day of bleeding were 102 × 109/L (40–181 × 109/L) and 1.36 (1.26–1.51), respectively. Eighty-seven percent patients (20/23) with severe bleeding received at least one blood component in response to bleeding. Two patients received antifibrinolytics. Patients with severe bleeding had significantly fewer PICU-free days (p = 0.001), fewer ventilator-free days (p < 0.001), and higher 28-day mortality (p = 0.003). CONCLUSIONS:. Severe bleeding occurred in nearly one-tenth of critically ill children with an underlying oncologic diagnosis without severe thrombocytopenia or coagulopathy. The vast majority received blood component therapy, but few received hemostatic medication. Studies are needed to guide the treatment of severe bleeding in this vulnerable patient population.Juliana Romano, MDMario Martinez, MDJulie Levasseur, MD, MPHJames S. Killinger, MDOliver Karam, MD, PhDMarianne E. Nellis, MD, MSWolters KluwerarticleMedical emergencies. Critical care. Intensive care. First aidRC86-88.9ENCritical Care Explorations, Vol 3, Iss 11, p e0572 (2021) |
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DOAJ |
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EN |
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Medical emergencies. Critical care. Intensive care. First aid RC86-88.9 |
| spellingShingle |
Medical emergencies. Critical care. Intensive care. First aid RC86-88.9 Juliana Romano, MD Mario Martinez, MD Julie Levasseur, MD, MPH James S. Killinger, MD Oliver Karam, MD, PhD Marianne E. Nellis, MD, MS Epidemiology of Bleeding in Critically Ill Children With an Underlying Oncologic Diagnosis |
| description |
OBJECTIVES:. Critically ill children with malignancy have significant risk of bleeding but the exact epidemiology is unknown. We sought to describe severe bleeding events and associated risk factors in critically ill pediatric patients with an underlying oncologic diagnosis using the newly developed Bleeding Assessment Scale in Critically Ill Children definition.
DESIGN:. Retrospective cohort study.
SETTING:. PICU in comprehensive cancer center,
PATIENTS:. Children ages 28 days to 18 years with an underlying oncologic diagnosis admitted to the PICU during 2018.
INTERVENTIONS:. None.
MEASUREMENTS AND MAIN RESULTS:. Two-hundred sixty-seven admissions met inclusion criteria. Sixty-four percent (171/267) were male, with a median (interquartile range) age of 6.3 years (3.1–12.1 yr). Nine percent (23/267) had at least one severe bleeding event during their PICU admission. There were no significant differences between those with severe bleeding and those without, with respect to gender (p = 0.07), age (p = 0.66), weight (p = 0.76), or transplant status (p = 0.18). There was a difference in the frequency of severe bleeding based on underlying oncologic diagnosis (p = 0.009). For patients with severe bleeding, the median (interquartile range) platelet count and international normalized ratio on the day of bleeding were 102 × 109/L (40–181 × 109/L) and 1.36 (1.26–1.51), respectively. Eighty-seven percent patients (20/23) with severe bleeding received at least one blood component in response to bleeding. Two patients received antifibrinolytics. Patients with severe bleeding had significantly fewer PICU-free days (p = 0.001), fewer ventilator-free days (p < 0.001), and higher 28-day mortality (p = 0.003).
CONCLUSIONS:. Severe bleeding occurred in nearly one-tenth of critically ill children with an underlying oncologic diagnosis without severe thrombocytopenia or coagulopathy. The vast majority received blood component therapy, but few received hemostatic medication. Studies are needed to guide the treatment of severe bleeding in this vulnerable patient population. |
| format |
article |
| author |
Juliana Romano, MD Mario Martinez, MD Julie Levasseur, MD, MPH James S. Killinger, MD Oliver Karam, MD, PhD Marianne E. Nellis, MD, MS |
| author_facet |
Juliana Romano, MD Mario Martinez, MD Julie Levasseur, MD, MPH James S. Killinger, MD Oliver Karam, MD, PhD Marianne E. Nellis, MD, MS |
| author_sort |
Juliana Romano, MD |
| title |
Epidemiology of Bleeding in Critically Ill Children With an Underlying Oncologic Diagnosis |
| title_short |
Epidemiology of Bleeding in Critically Ill Children With an Underlying Oncologic Diagnosis |
| title_full |
Epidemiology of Bleeding in Critically Ill Children With an Underlying Oncologic Diagnosis |
| title_fullStr |
Epidemiology of Bleeding in Critically Ill Children With an Underlying Oncologic Diagnosis |
| title_full_unstemmed |
Epidemiology of Bleeding in Critically Ill Children With an Underlying Oncologic Diagnosis |
| title_sort |
epidemiology of bleeding in critically ill children with an underlying oncologic diagnosis |
| publisher |
Wolters Kluwer |
| publishDate |
2021 |
| url |
https://doaj.org/article/081ba4f6cca3476a87048ae75fc0f592 |
| work_keys_str_mv |
AT julianaromanomd epidemiologyofbleedingincriticallyillchildrenwithanunderlyingoncologicdiagnosis AT mariomartinezmd epidemiologyofbleedingincriticallyillchildrenwithanunderlyingoncologicdiagnosis AT julielevasseurmdmph epidemiologyofbleedingincriticallyillchildrenwithanunderlyingoncologicdiagnosis AT jamesskillingermd epidemiologyofbleedingincriticallyillchildrenwithanunderlyingoncologicdiagnosis AT oliverkarammdphd epidemiologyofbleedingincriticallyillchildrenwithanunderlyingoncologicdiagnosis AT marianneenellismdms epidemiologyofbleedingincriticallyillchildrenwithanunderlyingoncologicdiagnosis |
| _version_ |
1718413600504152064 |