Early effect of percutaneous coronary intervention of non-left anterior descending artery on coronary flow velocity reserve of left anterior descending artery assessed by transthoracic Doppler echocardiography.

<h4>Background</h4>Limited data are available regarding the influence of percutaneous coronary intervention (PCI) of non-totally occluded lesions (non-CTO) on the coronary flow of non-target vessels. We sought to investigate the short-term impact of the non-left anterior descending arter...

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Autores principales:	Masahiro Hada, Masahiro Hoshino, Nobutaka Wakasa, Tomoyo Sugiyama, Yoshihisa Kanaji, Masao Yamaguchi, Toru Misawa, Tatsuhiro Nagamine, Kai Nogami, Yumi Yasui, Taishi Yonetsu, Tetsuo Sasano, Tsunekazu Kakuta
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/081c32bd3d7f4ce4b28d62c2cf70284b
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spelling	oai:doaj.org-article:081c32bd3d7f4ce4b28d62c2cf70284b2021-12-02T20:18:07ZEarly effect of percutaneous coronary intervention of non-left anterior descending artery on coronary flow velocity reserve of left anterior descending artery assessed by transthoracic Doppler echocardiography.1932-620310.1371/journal.pone.0256161https://doaj.org/article/081c32bd3d7f4ce4b28d62c2cf70284b2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0256161https://doaj.org/toc/1932-6203<h4>Background</h4>Limited data are available regarding the influence of percutaneous coronary intervention (PCI) of non-totally occluded lesions (non-CTO) on the coronary flow of non-target vessels. We sought to investigate the short-term impact of the non-left anterior descending artery (non-LAD) PCI on the coronary flow physiology of LAD using transthoracic Doppler echocardiography (TDE).<h4>Methods and results</h4>We consecutively studied 50 patients who underwent successful PCI of non-LAD and non-CTO lesions and a coronary flow velocity assessment of LAD at rest and maximal hyperemia before and at 2 days after the procedure by TDE. Coronary flow velocity reserve (CFVR) was calculated as the ratio of hyperemic to resting diastolic peak velocity (hDPV/bDPV). We evaluated the changes in LAD coronary flow characteristics after PCI of non-LAD and explored the determinants of the change in LAD-CFVR. The median fractional flow reserve (FFR) of the culprit lesion and the LAD quantitative flow ratio (QFR) were 0.67 and 0.88, respectively. After non-LAD PCI, LAD-CFVR was decreased in 33 patients (66.0%). LAD-CFVR significantly decreased (pre-PCI: 2.41, post-PCI: 2.03, p = 0.001) due to a significant decrease in LAD-hDPV (P = 0.007). The prevalence of impaired LAD-CFVR (≤2.0) significantly increased (pre: 30%, post: 48%, P = 0.027). Multivariable linear regression analysis showed that pre-PCI LAD-CFVR was independent predictor of the change in LAD-CFVR after PCI.<h4>Conclusions</h4>LAD-CFVR significantly decreased after successful non-LAD PCI due to the postprocedural reduction of coronary flow assessed by LAD-hDPV.Masahiro HadaMasahiro HoshinoNobutaka WakasaTomoyo SugiyamaYoshihisa KanajiMasao YamaguchiToru MisawaTatsuhiro NagamineKai NogamiYumi YasuiTaishi YonetsuTetsuo SasanoTsunekazu KakutaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0256161 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Masahiro Hada Masahiro Hoshino Nobutaka Wakasa Tomoyo Sugiyama Yoshihisa Kanaji Masao Yamaguchi Toru Misawa Tatsuhiro Nagamine Kai Nogami Yumi Yasui Taishi Yonetsu Tetsuo Sasano Tsunekazu Kakuta Early effect of percutaneous coronary intervention of non-left anterior descending artery on coronary flow velocity reserve of left anterior descending artery assessed by transthoracic Doppler echocardiography.
description	<h4>Background</h4>Limited data are available regarding the influence of percutaneous coronary intervention (PCI) of non-totally occluded lesions (non-CTO) on the coronary flow of non-target vessels. We sought to investigate the short-term impact of the non-left anterior descending artery (non-LAD) PCI on the coronary flow physiology of LAD using transthoracic Doppler echocardiography (TDE).<h4>Methods and results</h4>We consecutively studied 50 patients who underwent successful PCI of non-LAD and non-CTO lesions and a coronary flow velocity assessment of LAD at rest and maximal hyperemia before and at 2 days after the procedure by TDE. Coronary flow velocity reserve (CFVR) was calculated as the ratio of hyperemic to resting diastolic peak velocity (hDPV/bDPV). We evaluated the changes in LAD coronary flow characteristics after PCI of non-LAD and explored the determinants of the change in LAD-CFVR. The median fractional flow reserve (FFR) of the culprit lesion and the LAD quantitative flow ratio (QFR) were 0.67 and 0.88, respectively. After non-LAD PCI, LAD-CFVR was decreased in 33 patients (66.0%). LAD-CFVR significantly decreased (pre-PCI: 2.41, post-PCI: 2.03, p = 0.001) due to a significant decrease in LAD-hDPV (P = 0.007). The prevalence of impaired LAD-CFVR (≤2.0) significantly increased (pre: 30%, post: 48%, P = 0.027). Multivariable linear regression analysis showed that pre-PCI LAD-CFVR was independent predictor of the change in LAD-CFVR after PCI.<h4>Conclusions</h4>LAD-CFVR significantly decreased after successful non-LAD PCI due to the postprocedural reduction of coronary flow assessed by LAD-hDPV.
format	article
author	Masahiro Hada Masahiro Hoshino Nobutaka Wakasa Tomoyo Sugiyama Yoshihisa Kanaji Masao Yamaguchi Toru Misawa Tatsuhiro Nagamine Kai Nogami Yumi Yasui Taishi Yonetsu Tetsuo Sasano Tsunekazu Kakuta
author_facet	Masahiro Hada Masahiro Hoshino Nobutaka Wakasa Tomoyo Sugiyama Yoshihisa Kanaji Masao Yamaguchi Toru Misawa Tatsuhiro Nagamine Kai Nogami Yumi Yasui Taishi Yonetsu Tetsuo Sasano Tsunekazu Kakuta
author_sort	Masahiro Hada
title	Early effect of percutaneous coronary intervention of non-left anterior descending artery on coronary flow velocity reserve of left anterior descending artery assessed by transthoracic Doppler echocardiography.
title_short	Early effect of percutaneous coronary intervention of non-left anterior descending artery on coronary flow velocity reserve of left anterior descending artery assessed by transthoracic Doppler echocardiography.
title_full	Early effect of percutaneous coronary intervention of non-left anterior descending artery on coronary flow velocity reserve of left anterior descending artery assessed by transthoracic Doppler echocardiography.
title_fullStr	Early effect of percutaneous coronary intervention of non-left anterior descending artery on coronary flow velocity reserve of left anterior descending artery assessed by transthoracic Doppler echocardiography.
title_full_unstemmed	Early effect of percutaneous coronary intervention of non-left anterior descending artery on coronary flow velocity reserve of left anterior descending artery assessed by transthoracic Doppler echocardiography.
title_sort	early effect of percutaneous coronary intervention of non-left anterior descending artery on coronary flow velocity reserve of left anterior descending artery assessed by transthoracic doppler echocardiography.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/081c32bd3d7f4ce4b28d62c2cf70284b
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Early effect of percutaneous coronary intervention of non-left anterior descending artery on coronary flow velocity reserve of left anterior descending artery assessed by transthoracic Doppler echocardiography.

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