Systematic analysis reveals the prevalence and principles of bypassable gene essentiality

Systematic analysis reveals the prevalence and principles of bypassable gene essentiality

An essential gene may become non-essential when another gene is mutated. Here, the authors investigate this type of digenic interaction, termed ‘bypass of essentiality’, in the fission yeast Schizosaccharomyces pombe, and show that bypassable essential genes are common and share certain features....

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Auteurs principaux: Jun Li, Hai-Tao Wang, Wei-Tao Wang, Xiao-Ran Zhang, Fang Suo, Jing-Yi Ren, Ying Bi, Ying-Xi Xue, Wen Hu, Meng-Qiu Dong, Li-Lin Du
Format: article
Langue:EN
Publié: Nature Portfolio 2019
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Accès en ligne:https://doaj.org/article/081d51e49b2e42a4b1235dc234b85b81
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id oai:doaj.org-article:081d51e49b2e42a4b1235dc234b85b81
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spelling oai:doaj.org-article:081d51e49b2e42a4b1235dc234b85b812021-12-02T17:31:52ZSystematic analysis reveals the prevalence and principles of bypassable gene essentiality10.1038/s41467-019-08928-12041-1723https://doaj.org/article/081d51e49b2e42a4b1235dc234b85b812019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08928-1https://doaj.org/toc/2041-1723An essential gene may become non-essential when another gene is mutated. Here, the authors investigate this type of digenic interaction, termed ‘bypass of essentiality’, in the fission yeast Schizosaccharomyces pombe, and show that bypassable essential genes are common and share certain features.Jun LiHai-Tao WangWei-Tao WangXiao-Ran ZhangFang SuoJing-Yi RenYing BiYing-Xi XueWen HuMeng-Qiu DongLi-Lin DuNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jun Li
Hai-Tao Wang
Wei-Tao Wang
Xiao-Ran Zhang
Fang Suo
Jing-Yi Ren
Ying Bi
Ying-Xi Xue
Wen Hu
Meng-Qiu Dong
Li-Lin Du
Systematic analysis reveals the prevalence and principles of bypassable gene essentiality
description An essential gene may become non-essential when another gene is mutated. Here, the authors investigate this type of digenic interaction, termed ‘bypass of essentiality’, in the fission yeast Schizosaccharomyces pombe, and show that bypassable essential genes are common and share certain features.
format article
author Jun Li
Hai-Tao Wang
Wei-Tao Wang
Xiao-Ran Zhang
Fang Suo
Jing-Yi Ren
Ying Bi
Ying-Xi Xue
Wen Hu
Meng-Qiu Dong
Li-Lin Du
author_facet Jun Li
Hai-Tao Wang
Wei-Tao Wang
Xiao-Ran Zhang
Fang Suo
Jing-Yi Ren
Ying Bi
Ying-Xi Xue
Wen Hu
Meng-Qiu Dong
Li-Lin Du
author_sort Jun Li
title Systematic analysis reveals the prevalence and principles of bypassable gene essentiality
title_short Systematic analysis reveals the prevalence and principles of bypassable gene essentiality
title_full Systematic analysis reveals the prevalence and principles of bypassable gene essentiality
title_fullStr Systematic analysis reveals the prevalence and principles of bypassable gene essentiality
title_full_unstemmed Systematic analysis reveals the prevalence and principles of bypassable gene essentiality
title_sort systematic analysis reveals the prevalence and principles of bypassable gene essentiality
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/081d51e49b2e42a4b1235dc234b85b81
work_keys_str_mv AT junli systematicanalysisrevealstheprevalenceandprinciplesofbypassablegeneessentiality
AT haitaowang systematicanalysisrevealstheprevalenceandprinciplesofbypassablegeneessentiality
AT weitaowang systematicanalysisrevealstheprevalenceandprinciplesofbypassablegeneessentiality
AT xiaoranzhang systematicanalysisrevealstheprevalenceandprinciplesofbypassablegeneessentiality
AT fangsuo systematicanalysisrevealstheprevalenceandprinciplesofbypassablegeneessentiality
AT jingyiren systematicanalysisrevealstheprevalenceandprinciplesofbypassablegeneessentiality
AT yingbi systematicanalysisrevealstheprevalenceandprinciplesofbypassablegeneessentiality
AT yingxixue systematicanalysisrevealstheprevalenceandprinciplesofbypassablegeneessentiality
AT wenhu systematicanalysisrevealstheprevalenceandprinciplesofbypassablegeneessentiality
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