PMMA Bone Cements Modified with Silane-Treated and PMMA-Grafted Hydroxyapatite Nanocrystals: Preparation and Characterization

In this study, vinyltrimethoxysilane-treated hydroxyapatite (vHAP) and PMMA-grafted HAP (gHAP) were successfully prepared from original HAP (oHAP). Three kinds of HAP (oHAP, vHAP and g HAP) were used as additives for the preparation of three groups of HAP-modified PMMA bone cements (oHAP-BC, vHAP-BC...

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Autores principales:	Do Quang Tham, Mai Duc Huynh, Nguyen Thi Dieu Linh, Do Thi Cam Van, Do Van Cong, Nguyen Thi Kim Dung, Nguyen Thi Thu Trang, Pham Van Lam, Thai Hoang, Tran Dai Lam
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	HAP-modified bone cement vinyltrimethoxysilane-treated HAP PMMA-grafted HAP bending ISO 5833 Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/081d908ac96d41baa5b7b75ccd144fd5
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spelling	oai:doaj.org-article:081d908ac96d41baa5b7b75ccd144fd52021-11-25T18:47:43ZPMMA Bone Cements Modified with Silane-Treated and PMMA-Grafted Hydroxyapatite Nanocrystals: Preparation and Characterization10.3390/polym132238602073-4360https://doaj.org/article/081d908ac96d41baa5b7b75ccd144fd52021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4360/13/22/3860https://doaj.org/toc/2073-4360In this study, vinyltrimethoxysilane-treated hydroxyapatite (vHAP) and PMMA-grafted HAP (gHAP) were successfully prepared from original HAP (oHAP). Three kinds of HAP (oHAP, vHAP and g HAP) were used as additives for the preparation of three groups of HAP-modified PMMA bone cements (oHAP-BC, vHAP-BC and gHAP-BC). The setting, bending and compression properties of the bone cements were conducted according to ISO 5833:2002. The obtained results showed that the maximum temperature while curing the HAP-modified bone cements (HAP-BCs) decreased from 64.9 to 60.8 °C and the setting time increased from 8.1 to 14.0 min, respectively, with increasing HAP loading from 0 to 15 wt.%. The vHAP-BC and gHAP-BC groups exhibited higher mechanical properties than the required values in ISO 5833. Electron microscopy images showed that the vHAP and gHAP nanoparticles were dispersed better in the polymerized PMMA matrix than the oHAP nanoparticles. FTIR analysis indicated the polar interaction between the PO<sub>4</sub> groups of the HAP nanoparticles and the ester groups of the polymerized PMMA matrix. Thermal gravimetric analysis indicated that mixtures of ZrO<sub>2</sub>/HAPs were not able to significantly improve the thermal stability of the HAP-BCs. DSC diagrams showed that the incorporation of gHAP to PMMA bone cement with loadings lower than 10 wt.% can increase T<sub>g</sub> by about 2.4 °C.Do Quang ThamMai Duc HuynhNguyen Thi Dieu LinhDo Thi Cam VanDo Van CongNguyen Thi Kim DungNguyen Thi Thu TrangPham Van LamThai HoangTran Dai LamMDPI AGarticleHAP-modified bone cementvinyltrimethoxysilane-treated HAPPMMA-grafted HAPbendingISO 5833Organic chemistryQD241-441ENPolymers, Vol 13, Iss 3860, p 3860 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	HAP-modified bone cement vinyltrimethoxysilane-treated HAP PMMA-grafted HAP bending ISO 5833 Organic chemistry QD241-441
spellingShingle	HAP-modified bone cement vinyltrimethoxysilane-treated HAP PMMA-grafted HAP bending ISO 5833 Organic chemistry QD241-441 Do Quang Tham Mai Duc Huynh Nguyen Thi Dieu Linh Do Thi Cam Van Do Van Cong Nguyen Thi Kim Dung Nguyen Thi Thu Trang Pham Van Lam Thai Hoang Tran Dai Lam PMMA Bone Cements Modified with Silane-Treated and PMMA-Grafted Hydroxyapatite Nanocrystals: Preparation and Characterization
description	In this study, vinyltrimethoxysilane-treated hydroxyapatite (vHAP) and PMMA-grafted HAP (gHAP) were successfully prepared from original HAP (oHAP). Three kinds of HAP (oHAP, vHAP and g HAP) were used as additives for the preparation of three groups of HAP-modified PMMA bone cements (oHAP-BC, vHAP-BC and gHAP-BC). The setting, bending and compression properties of the bone cements were conducted according to ISO 5833:2002. The obtained results showed that the maximum temperature while curing the HAP-modified bone cements (HAP-BCs) decreased from 64.9 to 60.8 °C and the setting time increased from 8.1 to 14.0 min, respectively, with increasing HAP loading from 0 to 15 wt.%. The vHAP-BC and gHAP-BC groups exhibited higher mechanical properties than the required values in ISO 5833. Electron microscopy images showed that the vHAP and gHAP nanoparticles were dispersed better in the polymerized PMMA matrix than the oHAP nanoparticles. FTIR analysis indicated the polar interaction between the PO<sub>4</sub> groups of the HAP nanoparticles and the ester groups of the polymerized PMMA matrix. Thermal gravimetric analysis indicated that mixtures of ZrO<sub>2</sub>/HAPs were not able to significantly improve the thermal stability of the HAP-BCs. DSC diagrams showed that the incorporation of gHAP to PMMA bone cement with loadings lower than 10 wt.% can increase T<sub>g</sub> by about 2.4 °C.
format	article
author	Do Quang Tham Mai Duc Huynh Nguyen Thi Dieu Linh Do Thi Cam Van Do Van Cong Nguyen Thi Kim Dung Nguyen Thi Thu Trang Pham Van Lam Thai Hoang Tran Dai Lam
author_facet	Do Quang Tham Mai Duc Huynh Nguyen Thi Dieu Linh Do Thi Cam Van Do Van Cong Nguyen Thi Kim Dung Nguyen Thi Thu Trang Pham Van Lam Thai Hoang Tran Dai Lam
author_sort	Do Quang Tham
title	PMMA Bone Cements Modified with Silane-Treated and PMMA-Grafted Hydroxyapatite Nanocrystals: Preparation and Characterization
title_short	PMMA Bone Cements Modified with Silane-Treated and PMMA-Grafted Hydroxyapatite Nanocrystals: Preparation and Characterization
title_full	PMMA Bone Cements Modified with Silane-Treated and PMMA-Grafted Hydroxyapatite Nanocrystals: Preparation and Characterization
title_fullStr	PMMA Bone Cements Modified with Silane-Treated and PMMA-Grafted Hydroxyapatite Nanocrystals: Preparation and Characterization
title_full_unstemmed	PMMA Bone Cements Modified with Silane-Treated and PMMA-Grafted Hydroxyapatite Nanocrystals: Preparation and Characterization
title_sort	pmma bone cements modified with silane-treated and pmma-grafted hydroxyapatite nanocrystals: preparation and characterization
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/081d908ac96d41baa5b7b75ccd144fd5
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PMMA Bone Cements Modified with Silane-Treated and PMMA-Grafted Hydroxyapatite Nanocrystals: Preparation and Characterization

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