Exhaled volatilome analysis as a useful tool to discriminate asthma with other coexisting atopic diseases in women of childbearing age

Abstract The prevalence of asthma is considerably high among women of childbearing age. Most asthmatic women also often have other atopic disorders. Therefore, the differentiation between patients with atopic diseases without asthma and asthmatics with coexisting diseases is essential to avoid under...

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Autores principales:	Rosa A. Sola-Martínez, Gema Lozano-Terol, Julia Gallego-Jara, Eva Morales, Esther Cantero-Cano, Manuel Sanchez-Solis, Luis García-Marcos, Pedro Jiménez-Guerrero, José A. Noguera-Velasco, Manuel Cánovas Díaz, Teresa de Diego Puente, the NELA study group
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/082180fcfc1142d2bc21a7d6576996a0
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spelling	oai:doaj.org-article:082180fcfc1142d2bc21a7d6576996a02021-12-02T16:14:55ZExhaled volatilome analysis as a useful tool to discriminate asthma with other coexisting atopic diseases in women of childbearing age10.1038/s41598-021-92933-22045-2322https://doaj.org/article/082180fcfc1142d2bc21a7d6576996a02021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92933-2https://doaj.org/toc/2045-2322Abstract The prevalence of asthma is considerably high among women of childbearing age. Most asthmatic women also often have other atopic disorders. Therefore, the differentiation between patients with atopic diseases without asthma and asthmatics with coexisting diseases is essential to avoid underdiagnosis of asthma and to design strategies to reduce symptom severity and improve quality of life of patients. Hence, we aimed for the first time to conduct an analysis of volatile organic compounds in exhaled breath of women of childbearing age as a new approach to discriminate between asthmatics with other coexisting atopic diseases and non-asthmatics (with or without atopic diseases), which could be a helpful tool for more accurate asthma detection and monitoring using a noninvasive technique in the near future. In this study, exhaled air samples of 336 women (training set (n = 211) and validation set (n = 125)) were collected and analyzed by thermal desorption coupled with gas chromatography-mass spectrometry. ASCA (ANOVA (analysis of variance) simultaneous component analysis) and LASSO + LS (least absolute shrinkage and selection operator + logistic regression) were employed for data analysis. Fifteen statistically significant models (p-value < 0.05 in permutation tests) that discriminated asthma with other coexisting atopic diseases in women of childbearing age were generated. Acetone, 2-ethyl-1-hexanol and a tetrahydroisoquinoline derivative were selected as discriminants of asthma with other coexisting atopic diseases. In addition, carbon disulfide, a tetrahydroisoquinoline derivative, 2-ethyl-1-hexanol and decane discriminated asthma disease among patients with other atopic disorders. Results of this study indicate that refined metabolomic analysis of exhaled breath allows asthma with other coexisting atopic diseases discrimination in women of reproductive age.Rosa A. Sola-MartínezGema Lozano-TerolJulia Gallego-JaraEva MoralesEsther Cantero-CanoManuel Sanchez-SolisLuis García-MarcosPedro Jiménez-GuerreroJosé A. Noguera-VelascoManuel Cánovas DíazTeresa de Diego Puentethe NELA study groupNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rosa A. Sola-Martínez Gema Lozano-Terol Julia Gallego-Jara Eva Morales Esther Cantero-Cano Manuel Sanchez-Solis Luis García-Marcos Pedro Jiménez-Guerrero José A. Noguera-Velasco Manuel Cánovas Díaz Teresa de Diego Puente the NELA study group Exhaled volatilome analysis as a useful tool to discriminate asthma with other coexisting atopic diseases in women of childbearing age
description	Abstract The prevalence of asthma is considerably high among women of childbearing age. Most asthmatic women also often have other atopic disorders. Therefore, the differentiation between patients with atopic diseases without asthma and asthmatics with coexisting diseases is essential to avoid underdiagnosis of asthma and to design strategies to reduce symptom severity and improve quality of life of patients. Hence, we aimed for the first time to conduct an analysis of volatile organic compounds in exhaled breath of women of childbearing age as a new approach to discriminate between asthmatics with other coexisting atopic diseases and non-asthmatics (with or without atopic diseases), which could be a helpful tool for more accurate asthma detection and monitoring using a noninvasive technique in the near future. In this study, exhaled air samples of 336 women (training set (n = 211) and validation set (n = 125)) were collected and analyzed by thermal desorption coupled with gas chromatography-mass spectrometry. ASCA (ANOVA (analysis of variance) simultaneous component analysis) and LASSO + LS (least absolute shrinkage and selection operator + logistic regression) were employed for data analysis. Fifteen statistically significant models (p-value < 0.05 in permutation tests) that discriminated asthma with other coexisting atopic diseases in women of childbearing age were generated. Acetone, 2-ethyl-1-hexanol and a tetrahydroisoquinoline derivative were selected as discriminants of asthma with other coexisting atopic diseases. In addition, carbon disulfide, a tetrahydroisoquinoline derivative, 2-ethyl-1-hexanol and decane discriminated asthma disease among patients with other atopic disorders. Results of this study indicate that refined metabolomic analysis of exhaled breath allows asthma with other coexisting atopic diseases discrimination in women of reproductive age.
format	article
author	Rosa A. Sola-Martínez Gema Lozano-Terol Julia Gallego-Jara Eva Morales Esther Cantero-Cano Manuel Sanchez-Solis Luis García-Marcos Pedro Jiménez-Guerrero José A. Noguera-Velasco Manuel Cánovas Díaz Teresa de Diego Puente the NELA study group
author_facet	Rosa A. Sola-Martínez Gema Lozano-Terol Julia Gallego-Jara Eva Morales Esther Cantero-Cano Manuel Sanchez-Solis Luis García-Marcos Pedro Jiménez-Guerrero José A. Noguera-Velasco Manuel Cánovas Díaz Teresa de Diego Puente the NELA study group
author_sort	Rosa A. Sola-Martínez
title	Exhaled volatilome analysis as a useful tool to discriminate asthma with other coexisting atopic diseases in women of childbearing age
title_short	Exhaled volatilome analysis as a useful tool to discriminate asthma with other coexisting atopic diseases in women of childbearing age
title_full	Exhaled volatilome analysis as a useful tool to discriminate asthma with other coexisting atopic diseases in women of childbearing age
title_fullStr	Exhaled volatilome analysis as a useful tool to discriminate asthma with other coexisting atopic diseases in women of childbearing age
title_full_unstemmed	Exhaled volatilome analysis as a useful tool to discriminate asthma with other coexisting atopic diseases in women of childbearing age
title_sort	exhaled volatilome analysis as a useful tool to discriminate asthma with other coexisting atopic diseases in women of childbearing age
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/082180fcfc1142d2bc21a7d6576996a0
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Exhaled volatilome analysis as a useful tool to discriminate asthma with other coexisting atopic diseases in women of childbearing age

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