Phage-assisted continuous evolution of proteases with altered substrate specificity

Proteases are promising therapeutics to treat diseases such as hemophilia which are due to endogenous protease deficiency. Here the authors use phage-assisted continuous evolution to evolve a variant TEV protease with altered target peptide sequence specificities.

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Detalles Bibliográficos
Autores principales:	Michael S. Packer, Holly A. Rees, David R. Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/08222d2b844046fe8d313002c7e42c08
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spelling	oai:doaj.org-article:08222d2b844046fe8d313002c7e42c082021-12-02T15:38:52ZPhage-assisted continuous evolution of proteases with altered substrate specificity10.1038/s41467-017-01055-92041-1723https://doaj.org/article/08222d2b844046fe8d313002c7e42c082017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01055-9https://doaj.org/toc/2041-1723Proteases are promising therapeutics to treat diseases such as hemophilia which are due to endogenous protease deficiency. Here the authors use phage-assisted continuous evolution to evolve a variant TEV protease with altered target peptide sequence specificities.Michael S. PackerHolly A. ReesDavid R. LiuNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Michael S. Packer Holly A. Rees David R. Liu Phage-assisted continuous evolution of proteases with altered substrate specificity
description	Proteases are promising therapeutics to treat diseases such as hemophilia which are due to endogenous protease deficiency. Here the authors use phage-assisted continuous evolution to evolve a variant TEV protease with altered target peptide sequence specificities.
format	article
author	Michael S. Packer Holly A. Rees David R. Liu
author_facet	Michael S. Packer Holly A. Rees David R. Liu
author_sort	Michael S. Packer
title	Phage-assisted continuous evolution of proteases with altered substrate specificity
title_short	Phage-assisted continuous evolution of proteases with altered substrate specificity
title_full	Phage-assisted continuous evolution of proteases with altered substrate specificity
title_fullStr	Phage-assisted continuous evolution of proteases with altered substrate specificity
title_full_unstemmed	Phage-assisted continuous evolution of proteases with altered substrate specificity
title_sort	phage-assisted continuous evolution of proteases with altered substrate specificity
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/08222d2b844046fe8d313002c7e42c08
work_keys_str_mv	AT michaelspacker phageassistedcontinuousevolutionofproteaseswithalteredsubstratespecificity AT hollyarees phageassistedcontinuousevolutionofproteaseswithalteredsubstratespecificity AT davidrliu phageassistedcontinuousevolutionofproteaseswithalteredsubstratespecificity
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Phage-assisted continuous evolution of proteases with altered substrate specificity

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