Phage-assisted continuous evolution of proteases with altered substrate specificity

Proteases are promising therapeutics to treat diseases such as hemophilia which are due to endogenous protease deficiency. Here the authors use phage-assisted continuous evolution to evolve a variant TEV protease with altered target peptide sequence specificities.

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Detalles Bibliográficos
Autores principales: Michael S. Packer, Holly A. Rees, David R. Liu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Q
Acceso en línea:https://doaj.org/article/08222d2b844046fe8d313002c7e42c08
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